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- W2012606992 abstract "Recent studies suggest that the nature of events leading to the formation, maintenance, and elimination of synapses may be regulated by cascade-type, locally expressed proteases and protease inhibitors acting on adhesive extracellular matrix components. We have identified a molecule in conditioned medium of murine skeletal muscle cells that in molecular weight, target protease inhibition, heparin-binding and cross-reactivity with authenic antisera is similar to the human serine proteinase inhibitor, protease nexin I. Protease nexin I is a 43–50 kDa glycoprotein of the serpin superfamily (arg-serpin class). Purified anti-protease nexin I antibody (anti-47 kDa) stains adult mouse skeletal muscle in discrete foci that precisely superimpose on synaptic neuromuscular junctions. Protease nexin I appears in patches on surfaces of cultured mouse skeletal myotubes, but not on myoblasts. These patches co-localize with acetylcholine receptor clusters and acetylcholinesterase staining during cellular maturation in culture. Evidence that protease nexin I is a synaptic, extracellular antigen is particularly intriguing since it has been shown to be identical, in structure and activity, with a factor released by glial cells, called glia-derived nexin that stimulates mouse neuroblastoma cell neurite outgrowth and inhibits granule cell migration Protease nexin I inhibits both tumor cell and myoblast plasminogen activator-mediated destruction of extracellular matrix. Thus, such observations as presented in this report provide further evidence for involvement of cascade proteolytic systems, and their post-translational regulation by specific serpins, in the remodeling that occurs in synapse formation and elimination." @default.
- W2012606992 created "2016-06-24" @default.
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- W2012606992 date "1991-04-01" @default.
- W2012606992 modified "2023-10-17" @default.
- W2012606992 title "Plasminogen activators and inhibitors in the neuromuscular system: III. The serpin protease nexin I is synthesized by muscle and localized at neuromuscular synapses" @default.
- W2012606992 cites W110993326 @default.
- W2012606992 cites W1463270837 @default.
- W2012606992 cites W1480389324 @default.
- W2012606992 cites W1486021067 @default.
- W2012606992 cites W1489267547 @default.
- W2012606992 cites W1496740453 @default.
- W2012606992 cites W152474699 @default.
- W2012606992 cites W1550499229 @default.
- W2012606992 cites W1569209865 @default.
- W2012606992 cites W1587342184 @default.
- W2012606992 cites W1965983162 @default.
- W2012606992 cites W1975771446 @default.
- W2012606992 cites W1980094138 @default.
- W2012606992 cites W1983447138 @default.
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- W2012606992 cites W1991337902 @default.
- W2012606992 cites W1994238652 @default.
- W2012606992 cites W1996055359 @default.
- W2012606992 cites W2003921849 @default.
- W2012606992 cites W2005246591 @default.
- W2012606992 cites W2007672783 @default.
- W2012606992 cites W2013750006 @default.
- W2012606992 cites W2020763061 @default.
- W2012606992 cites W2022218141 @default.
- W2012606992 cites W2022446410 @default.
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- W2012606992 cites W2033465664 @default.
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- W2012606992 cites W2049480677 @default.
- W2012606992 cites W2054083197 @default.
- W2012606992 cites W2055755700 @default.
- W2012606992 cites W2056090701 @default.
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- W2012606992 cites W2064842318 @default.
- W2012606992 cites W2067310342 @default.
- W2012606992 cites W2069682857 @default.
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- W2012606992 doi "https://doi.org/10.1002/jcp.1041470111" @default.
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