FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012607521> ?p ?o ?g. }

• W2012607521 endingPage "122" @default.
• W2012607521 startingPage "114" @default.
• W2012607521 abstract "Using a high-throughput screening system involving HCV JFH-1-Huh 7.5.1 cells, we determined that the ligands of class II nuclear receptors, retinoids and rexinoids inhibit HCV infection. Retinoids, ligands of retinoic acid receptor (RAR), and rexinoids, ligands of retinoid X receptor (RXR), reduced extracellular HCV RNA of HCV infected cells in a dose-dependent manner. The 50% effective concentrations were below 10 nM, and the 50% cytotoxic concentrations were over 10 μM. Both agonists and antagonists demonstrated inhibition, which indicates that the effect is not dependent on retinoic acid signaling. These chemicals reduced HCV RNA and NS5A protein levels in cells harboring the subgenomic HCV replicon RNA, which suggests that the chemicals affect HCV RNA replication. These compounds were also effective against persistently infected cells, although the reduction in the intracellular HCV RNA was smaller than that of the extracellular HCV RNA, suggesting that viral post-replication step is also inhibited. In combination with interferon (IFN), retinoid exhibited a synergistic effect. Retinoids did not enhance expression of the IFN effector molecule PKR. These series of compounds warrant further investigation as new class of HCV drugs, for the clinical translation of our observation may lead to increased anti-HCV efficacy." @default.
• W2012607521 created "2016-06-24" @default.
• W2012607521 creator A5024298099 @default.
• W2012607521 creator A5037974736 @default.
• W2012607521 creator A5078215874 @default.
• W2012607521 creator A5080080238 @default.
• W2012607521 creator A5082787667 @default.
• W2012607521 creator A5089303528 @default.
• W2012607521 date "2014-02-01" @default.
• W2012607521 modified "2023-10-03" @default.
• W2012607521 title "Retinoids and rexinoids inhibit hepatitis C virus independently of retinoid receptor signaling" @default.
• W2012607521 cites W1565471622 @default.
• W2012607521 cites W1596579583 @default.
• W2012607521 cites W1942009715 @default.
• W2012607521 cites W1971464824 @default.
• W2012607521 cites W1973329500 @default.
• W2012607521 cites W1973559037 @default.
• W2012607521 cites W1974733477 @default.
• W2012607521 cites W1980702122 @default.
• W2012607521 cites W1985939675 @default.
• W2012607521 cites W2003579943 @default.
• W2012607521 cites W2005036996 @default.
• W2012607521 cites W2016840057 @default.
• W2012607521 cites W2025396954 @default.
• W2012607521 cites W2035515246 @default.
• W2012607521 cites W2036268511 @default.
• W2012607521 cites W2041809495 @default.
• W2012607521 cites W2052499937 @default.
• W2012607521 cites W2070443240 @default.
• W2012607521 cites W2071268780 @default.
• W2012607521 cites W2072847189 @default.
• W2012607521 cites W2110842901 @default.
• W2012607521 cites W2118926211 @default.
• W2012607521 cites W2127378869 @default.
• W2012607521 cites W2133003425 @default.
• W2012607521 cites W2134435180 @default.
• W2012607521 cites W2138365237 @default.
• W2012607521 cites W2148214390 @default.
• W2012607521 cites W2151690631 @default.
• W2012607521 cites W2151898297 @default.
• W2012607521 cites W2162435876 @default.
• W2012607521 cites W2172184136 @default.
• W2012607521 cites W2314507989 @default.
• W2012607521 doi "https://doi.org/10.1016/j.micinf.2013.10.016" @default.
• W2012607521 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24177211" @default.
• W2012607521 hasPublicationYear "2014" @default.
• W2012607521 type Work @default.
• W2012607521 sameAs 2012607521 @default.
• W2012607521 citedByCount "3" @default.
• W2012607521 countsByYear W20126075212015 @default.
• W2012607521 countsByYear W20126075212021 @default.
• W2012607521 countsByYear W20126075212023 @default.
• W2012607521 crossrefType "journal-article" @default.
• W2012607521 hasAuthorship W2012607521A5024298099 @default.
• W2012607521 hasAuthorship W2012607521A5037974736 @default.
• W2012607521 hasAuthorship W2012607521A5078215874 @default.
• W2012607521 hasAuthorship W2012607521A5080080238 @default.
• W2012607521 hasAuthorship W2012607521A5082787667 @default.
• W2012607521 hasAuthorship W2012607521A5089303528 @default.
• W2012607521 hasConcept C104317684 @default.
• W2012607521 hasConcept C120197328 @default.
• W2012607521 hasConcept C128821507 @default.
• W2012607521 hasConcept C159047783 @default.
• W2012607521 hasConcept C170493617 @default.
• W2012607521 hasConcept C2522874641 @default.
• W2012607521 hasConcept C2775954498 @default.
• W2012607521 hasConcept C2776408679 @default.
• W2012607521 hasConcept C2777103181 @default.
• W2012607521 hasConcept C2778820923 @default.
• W2012607521 hasConcept C2781121885 @default.
• W2012607521 hasConcept C2781463415 @default.
• W2012607521 hasConcept C55493867 @default.
• W2012607521 hasConcept C63932345 @default.
• W2012607521 hasConcept C67705224 @default.
• W2012607521 hasConcept C68484354 @default.
• W2012607521 hasConcept C86339819 @default.
• W2012607521 hasConcept C86803240 @default.
• W2012607521 hasConceptScore W2012607521C104317684 @default.
• W2012607521 hasConceptScore W2012607521C120197328 @default.
• W2012607521 hasConceptScore W2012607521C128821507 @default.
• W2012607521 hasConceptScore W2012607521C159047783 @default.
• W2012607521 hasConceptScore W2012607521C170493617 @default.
• W2012607521 hasConceptScore W2012607521C2522874641 @default.
• W2012607521 hasConceptScore W2012607521C2775954498 @default.
• W2012607521 hasConceptScore W2012607521C2776408679 @default.
• W2012607521 hasConceptScore W2012607521C2777103181 @default.
• W2012607521 hasConceptScore W2012607521C2778820923 @default.
• W2012607521 hasConceptScore W2012607521C2781121885 @default.
• W2012607521 hasConceptScore W2012607521C2781463415 @default.
• W2012607521 hasConceptScore W2012607521C55493867 @default.
• W2012607521 hasConceptScore W2012607521C63932345 @default.
• W2012607521 hasConceptScore W2012607521C67705224 @default.
• W2012607521 hasConceptScore W2012607521C68484354 @default.
• W2012607521 hasConceptScore W2012607521C86339819 @default.
• W2012607521 hasConceptScore W2012607521C86803240 @default.
• W2012607521 hasIssue "2" @default.
• W2012607521 hasLocation W20126075211 @default.
• W2012607521 hasLocation W20126075212 @default.

• next