FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012607545> ?p ?o ?g. }

• W2012607545 endingPage "177" @default.
• W2012607545 startingPage "164" @default.
• W2012607545 abstract "The human immunodeficiency virus type-1 (HIV-1) integrase enzyme has recently emerged as a primary alternative target to block viral replication, and integrase strand transfer inhibitors (INSTIs) are now considered an alternative 'third agent' class of antiretroviral (ARV) drugs. Dolutegravir is the first next-generation INSTI showing some novel and intriguing characteristics: it has a favorable pharmacokinetic profile with a prolonged intracellular halflife, rendering feasible a once daily dosing without the need for pharmacokinetic boosting. Secondly, it is largely metabolized via uridine diphosphate glucuronosyltransferase-1A1 with a minor component of cytochrome P450 isoforms, thus allowing a low grade of drug-drug interactions, so that its metabolic profile consents co-administration with the majority of the other ARV drugs without dose adjustments. Lastly, but no less important, virological studies have clearly demonstrated that dolutegravir has a significant activity against HIV-1 isolates showing raltegravir and/or elvitegravir associated resistance mutations. The attributes of once daily administration and the potential to treat INSTI-resistant viruses make dolutegravir an interesting and promising new agent in the treatment of both naïve and experienced HIV-1 subjects. In this review, the main concerns on dolutegravir efficacy are focused through the analysis of the currently available data from clinical studies in naïve and experienced patients, evaluating its possible place within the anti-HIV-1 drug armamentarium. The development of newer once daily, single tablet coformulations improved drug adherence and maximized the success of ARV therapy. Pharmacokinetic studies and dose-ranging trials suggested that dolutegravir is a good candidate for a single tablet regimen in one or more new coformulated pills that will be available in the near future." @default.
• W2012607545 created "2016-06-24" @default.
• W2012607545 creator A5032969769 @default.
• W2012607545 creator A5055544432 @default.
• W2012607545 date "2014-04-15" @default.
• W2012607545 modified "2023-09-26" @default.
• W2012607545 title "Dolutegravir: clinical efficacy and role in HIV therapy" @default.
• W2012607545 cites W1078286986 @default.
• W2012607545 cites W1573558157 @default.
• W2012607545 cites W1982419299 @default.
• W2012607545 cites W1983837630 @default.
• W2012607545 cites W1990069515 @default.
• W2012607545 cites W1990925084 @default.
• W2012607545 cites W1991763748 @default.
• W2012607545 cites W2003964436 @default.
• W2012607545 cites W2007089324 @default.
• W2012607545 cites W2030038632 @default.
• W2012607545 cites W2034611990 @default.
• W2012607545 cites W2036917641 @default.
• W2012607545 cites W2042498919 @default.
• W2012607545 cites W2046246036 @default.
• W2012607545 cites W2048514971 @default.
• W2012607545 cites W2057925552 @default.
• W2012607545 cites W2059564465 @default.
• W2012607545 cites W2062514953 @default.
• W2012607545 cites W2066315689 @default.
• W2012607545 cites W2074171743 @default.
• W2012607545 cites W2075144974 @default.
• W2012607545 cites W2077998490 @default.
• W2012607545 cites W2085120686 @default.
• W2012607545 cites W2087400133 @default.
• W2012607545 cites W2094241860 @default.
• W2012607545 cites W2094811879 @default.
• W2012607545 cites W2098185748 @default.
• W2012607545 cites W2109360985 @default.
• W2012607545 cites W2109604183 @default.
• W2012607545 cites W2122026430 @default.
• W2012607545 cites W2123189246 @default.
• W2012607545 cites W2126563844 @default.
• W2012607545 cites W2132585743 @default.
• W2012607545 cites W2133117185 @default.
• W2012607545 cites W2139167304 @default.
• W2012607545 cites W2139430929 @default.
• W2012607545 cites W2139772076 @default.
• W2012607545 cites W2140123055 @default.
• W2012607545 cites W2142229639 @default.
• W2012607545 cites W2142973778 @default.
• W2012607545 cites W2144255757 @default.
• W2012607545 cites W2144854003 @default.
• W2012607545 cites W2149150781 @default.
• W2012607545 cites W2151589354 @default.
• W2012607545 cites W2152880150 @default.
• W2012607545 cites W2155792409 @default.
• W2012607545 cites W2165071365 @default.
• W2012607545 cites W2171103689 @default.
• W2012607545 cites W2171711893 @default.
• W2012607545 cites W2318289184 @default.
• W2012607545 doi "https://doi.org/10.1177/2040622314530461" @default.
• W2012607545 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4049127" @default.
• W2012607545 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24982751" @default.
• W2012607545 hasPublicationYear "2014" @default.
• W2012607545 type Work @default.
• W2012607545 sameAs 2012607545 @default.
• W2012607545 citedByCount "29" @default.
• W2012607545 countsByYear W20126075452015 @default.
• W2012607545 countsByYear W20126075452016 @default.
• W2012607545 countsByYear W20126075452017 @default.
• W2012607545 countsByYear W20126075452019 @default.
• W2012607545 countsByYear W20126075452021 @default.
• W2012607545 countsByYear W20126075452022 @default.
• W2012607545 countsByYear W20126075452023 @default.
• W2012607545 crossrefType "journal-article" @default.
• W2012607545 hasAuthorship W2012607545A5032969769 @default.
• W2012607545 hasAuthorship W2012607545A5055544432 @default.
• W2012607545 hasBestOaLocation W20126075452 @default.
• W2012607545 hasConcept C112705442 @default.
• W2012607545 hasConcept C142462285 @default.
• W2012607545 hasConcept C14430832 @default.
• W2012607545 hasConcept C159047783 @default.
• W2012607545 hasConcept C2777068322 @default.
• W2012607545 hasConcept C2777288759 @default.
• W2012607545 hasConcept C2777302000 @default.
• W2012607545 hasConcept C2779502633 @default.
• W2012607545 hasConcept C2780035454 @default.
• W2012607545 hasConcept C2780404665 @default.
• W2012607545 hasConcept C2993143319 @default.
• W2012607545 hasConcept C3013748606 @default.
• W2012607545 hasConcept C71924100 @default.
• W2012607545 hasConcept C98274493 @default.
• W2012607545 hasConceptScore W2012607545C112705442 @default.
• W2012607545 hasConceptScore W2012607545C142462285 @default.
• W2012607545 hasConceptScore W2012607545C14430832 @default.
• W2012607545 hasConceptScore W2012607545C159047783 @default.
• W2012607545 hasConceptScore W2012607545C2777068322 @default.
• W2012607545 hasConceptScore W2012607545C2777288759 @default.
• W2012607545 hasConceptScore W2012607545C2777302000 @default.
• W2012607545 hasConceptScore W2012607545C2779502633 @default.
• W2012607545 hasConceptScore W2012607545C2780035454 @default.

• next