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• W2012608542 abstract "You have accessJournal of UrologyBenign Prostatic Hyperplasia: Basic Research1 Apr 20131598 HYPEREXCITABILITY OF DICHOTOMIZED AND BLADDER AFFERENT NEURONS IN RATS WITH PROSTATIC INFLAMMATION: A INVOLVEMENT OF PROSTATE-TO-BLADDER AFFERENT CROSS-SENSITIZATION Ryosuke Takahashi, Yasuhito Funahashi, Seiji Naito, and Naoki Yoshimura Ryosuke TakahashiRyosuke Takahashi Fukuoka, Japan More articles by this author , Yasuhito FunahashiYasuhito Funahashi Nagoya, Japan More articles by this author , Seiji NaitoSeiji Naito Fukuoka, Japan More articles by this author , and Naoki YoshimuraNaoki Yoshimura Pittsburgh, PA More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.02.3148AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES There is increasing clinical evidences showing a positive relationship between the degree of prostatic inflammation and the severity of lower urinary tract symptoms (LUTS) in patients with benign prostatic hyperplasia (BPH). We previously reported that prostatic inflammation induces bladder overactivity through pelvic organ cross-sensitization (2012 AUA). However, the underlying functional mechanisms are not fully elucidated. We therefore examined changes in electrophysiological properties of dichotomized (bladder and prostate) afferent neurons (D-AN) and bladder afferent neurons (B-AN) obtained from prostatitis rats. METHODS Prostatic inflammation was induced by 5% formalin injection into the prostate of SD rats. After 1 week, L6-S1 dorsal root ganglia (DRG) were removed and whole cell patch-clamp recordings were performed on individual D-AN and B-AN, which were labeled by retrograde axonal transport of fluorescent dyes, Fast Blue (FB) or DiI, injected into the bladder wall or the prostate, respectively. Since the majority of C-fibers are sensitive to capsaicin, FB and/or DiI-labeled cells that exhibited inward currents in response to capsaicin application were selected for evaluation. The mRNA level of an A-type K+ channel (KA) subunit, Kv1.4 in D-AN and B-AN was evaluated by real-time RT-PCR using laser-capture microdissection methods. RESULTS Capsaicin-sensitive D-AN or B-AN from prostatitis rats exhibited lower thresholds for spike activation (-28.3±1.4 mV or -28.7±1.4 mV) compared to control rats (-19.5±1.1 mV or -21.3±2.2 mV). The number of action potentials of D-AN or B-AN during a 800 msec depolarizing pulse was significantly increased after prostatitis (5.1±0.7 or 3.5±0.4 spikes) compared to control rats (1.2±0.1 or 1.4±0.3 spikes). In prostatitis rats, Kv1.4 mRNA was significantly decreased in D-AN and B-AN compared to non-labeled neurons. In B-AN, the peak density of KA currents during membrane depolarization to 0 mV in prostatitis rats (39.3±5.9 pA/pF) was significantly smaller than that from control rats (76.5±11.0 pA/pF). CONCLUSIONS These results indicate that the excitability of capsaicin-sensitive C-fiber D-AN and B-AN is increased due to reduced KA activity associated with decreased expression of Kv1.4 α-subunit following prostatic inflammation. Thus, pelvic organ cross-sensitization between prostate and bladder could be an important mechanism inducing storage LUTS in BPH patients with prostatic inflammation. © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 189Issue 4SApril 2013Page: e656-e657 Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.Metrics Author Information Ryosuke Takahashi Fukuoka, Japan More articles by this author Yasuhito Funahashi Nagoya, Japan More articles by this author Seiji Naito Fukuoka, Japan More articles by this author Naoki Yoshimura Pittsburgh, PA More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ..." @default.
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• W2012608542 title "1598 HYPEREXCITABILITY OF DICHOTOMIZED AND BLADDER AFFERENT NEURONS IN RATS WITH PROSTATIC INFLAMMATION: A INVOLVEMENT OF PROSTATE-TO-BLADDER AFFERENT CROSS-SENSITIZATION" @default.
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