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• W2012608771 abstract "Pipeline (1 μM), a congener of capsaicin, produced an initial contraction, blocked the capsaicin-sensitive contractile response to mesenteric nerve stimulation and inhibited the twitch response induced by field stimulation in the isolated guinea-pig ileum. These three effects of piperine (1 μM) were rapidly desensitized and significantly antagonized by ruthenium red (0.5-1 μM), an inorganic dye known to antagonize the effects of capsaicin. The contractile effect of piperine was abolished by application of tetrodotoxin plus desensitization with substance P or by extrinsic denervation. The inhibitory effect of piperine (1 μM) on the twitch response was antagonized by desensitization with calcitonin gene-related peptide (CGRP). Moreover, cross-tachyphylaxis between piperine and capsaicin was observed, suggesting that a similar mechanism may be involved in the effects of these agents. The contractile effects induced by piperine (10 μM) and the subsequent inhibitory effects on the twitch response were not desensitized and largely persisted after extrinsic denervation. The contractile effects of piperine (10 μM) were not strongly inhibited by tetrodotoxin plus desensitization with substance P. It was concluded that the lower concentration of piperine caused contraction and inhibited the twitch responses by releasing substance P and CGRP, respectively, from sensory nerves, and blocked the response to mesenteric nerve stimulation by a mechanism similar to that of capsaicin. At higher concentrations, piperine had non-specific direct actions on the smooth muscle." @default.
• W2012608771 created "2016-06-24" @default.
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• W2012608771 date "1990-09-01" @default.
• W2012608771 modified "2023-10-18" @default.
• W2012608771 title "Effects of piperine on the motility of the isolated guinea-pig ileum: comparison with capsaicin" @default.
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• W2012608771 doi "https://doi.org/10.1016/0014-2999(90)94061-2" @default.
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