FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012617552> ?p ?o ?g. }

• W2012617552 endingPage "1497" @default.
• W2012617552 startingPage "1489" @default.
• W2012617552 abstract "Twenty resveratrol (3,5,4'-trihydroxystilbene) (Res) derivatives, which were isolated from stem bark of Vatica rassak (Dipterocarpaceae), were evaluated for in vitro cytotoxicity against a panel of human tumor cell lines. Among them, seven compounds displayed marked cytotoxicity. Vaticanol C (Vat C) as a major component induced a considerable cytotoxicity in all cell lines tested and exhibited growth suppression in colon cancer cell lines at low dose. Vat C caused two cell lines (SW480 and HL60) to induce cell death at four to seven times lower concentrations, compared with Res. The growth suppression by Vat C was found to be due to apoptosis, which was assessed by morphological findings (nuclear condensation and fragmentation) and DNA ladder formation in the colon cancer cell lines. The apoptosis in SW480 colon cancer cells was executed by the activation of caspase-3, which was shown by western blot and apoptosis inhibition assay. Furthermore, the mitochondrial membrane potential of apoptotic SW480 cells after 12 h treatment with Vat C was significantly lost, and concurrently the cytochrome c release and activation of caspase-9 were also detected by western blot analysis. Over-expression of Bcl-2 protein in SW480 cells significantly prevented the cell death induced by Vat C. Taken together, the findings presented here indicate that Vat C induced marked apoptosis in malignant cells mainly by affecting mitochondrial membrane potential." @default.
• W2012617552 created "2016-06-24" @default.
• W2012617552 creator A5034892730 @default.
• W2012617552 date "2003-07-04" @default.
• W2012617552 modified "2023-10-04" @default.
• W2012617552 title "Antitumor effect of resveratrol oligomers against human cancer cell lines and the molecular mechanism of apoptosis induced by vaticanol C" @default.
• W2012617552 cites W145786783 @default.
• W2012617552 cites W1483201954 @default.
• W2012617552 cites W1950456672 @default.
• W2012617552 cites W1974231710 @default.
• W2012617552 cites W1979011467 @default.
• W2012617552 cites W1980437524 @default.
• W2012617552 cites W1982028925 @default.
• W2012617552 cites W1986885743 @default.
• W2012617552 cites W1989865662 @default.
• W2012617552 cites W1989969820 @default.
• W2012617552 cites W2000470120 @default.
• W2012617552 cites W2008705266 @default.
• W2012617552 cites W2012896271 @default.
• W2012617552 cites W2019913413 @default.
• W2012617552 cites W2024693607 @default.
• W2012617552 cites W2027848184 @default.
• W2012617552 cites W2031410102 @default.
• W2012617552 cites W2042935092 @default.
• W2012617552 cites W2052340941 @default.
• W2012617552 cites W2075576299 @default.
• W2012617552 cites W2077963707 @default.
• W2012617552 cites W2081690888 @default.
• W2012617552 cites W2086365629 @default.
• W2012617552 cites W2092654095 @default.
• W2012617552 cites W2096715368 @default.
• W2012617552 cites W2097791313 @default.
• W2012617552 cites W2110452703 @default.
• W2012617552 cites W2151089147 @default.
• W2012617552 cites W2152586064 @default.
• W2012617552 cites W2165030642 @default.
• W2012617552 cites W2166185936 @default.
• W2012617552 cites W2168496647 @default.
• W2012617552 cites W2140819263 @default.
• W2012617552 doi "https://doi.org/10.1093/carcin/bgg105" @default.
• W2012617552 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12844481" @default.
• W2012617552 hasPublicationYear "2003" @default.
• W2012617552 type Work @default.
• W2012617552 sameAs 2012617552 @default.
• W2012617552 citedByCount "115" @default.
• W2012617552 countsByYear W20126175522012 @default.
• W2012617552 countsByYear W20126175522013 @default.
• W2012617552 countsByYear W20126175522014 @default.
• W2012617552 countsByYear W20126175522015 @default.
• W2012617552 countsByYear W20126175522016 @default.
• W2012617552 countsByYear W20126175522017 @default.
• W2012617552 countsByYear W20126175522018 @default.
• W2012617552 countsByYear W20126175522019 @default.
• W2012617552 countsByYear W20126175522020 @default.
• W2012617552 countsByYear W20126175522021 @default.
• W2012617552 countsByYear W20126175522022 @default.
• W2012617552 countsByYear W20126175522023 @default.
• W2012617552 crossrefType "journal-article" @default.
• W2012617552 hasAuthorship W2012617552A5034892730 @default.
• W2012617552 hasBestOaLocation W20126175521 @default.
• W2012617552 hasConcept C104317684 @default.
• W2012617552 hasConcept C109316439 @default.
• W2012617552 hasConcept C153911025 @default.
• W2012617552 hasConcept C185592680 @default.
• W2012617552 hasConcept C18903297 @default.
• W2012617552 hasConcept C190283241 @default.
• W2012617552 hasConcept C191015642 @default.
• W2012617552 hasConcept C202751555 @default.
• W2012617552 hasConcept C2776415932 @default.
• W2012617552 hasConcept C2778903051 @default.
• W2012617552 hasConcept C29311851 @default.
• W2012617552 hasConcept C31573885 @default.
• W2012617552 hasConcept C43759708 @default.
• W2012617552 hasConcept C502942594 @default.
• W2012617552 hasConcept C54355233 @default.
• W2012617552 hasConcept C55493867 @default.
• W2012617552 hasConcept C81885089 @default.
• W2012617552 hasConcept C86803240 @default.
• W2012617552 hasConceptScore W2012617552C104317684 @default.
• W2012617552 hasConceptScore W2012617552C109316439 @default.
• W2012617552 hasConceptScore W2012617552C153911025 @default.
• W2012617552 hasConceptScore W2012617552C185592680 @default.
• W2012617552 hasConceptScore W2012617552C18903297 @default.
• W2012617552 hasConceptScore W2012617552C190283241 @default.
• W2012617552 hasConceptScore W2012617552C191015642 @default.
• W2012617552 hasConceptScore W2012617552C202751555 @default.
• W2012617552 hasConceptScore W2012617552C2776415932 @default.
• W2012617552 hasConceptScore W2012617552C2778903051 @default.
• W2012617552 hasConceptScore W2012617552C29311851 @default.
• W2012617552 hasConceptScore W2012617552C31573885 @default.
• W2012617552 hasConceptScore W2012617552C43759708 @default.
• W2012617552 hasConceptScore W2012617552C502942594 @default.
• W2012617552 hasConceptScore W2012617552C54355233 @default.
• W2012617552 hasConceptScore W2012617552C55493867 @default.
• W2012617552 hasConceptScore W2012617552C81885089 @default.
• W2012617552 hasConceptScore W2012617552C86803240 @default.
• W2012617552 hasIssue "9" @default.
• W2012617552 hasLocation W20126175521 @default.

• next