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• W2012619962 abstract "ObjectiveTo assess the course of sexual function in epilepsy patients treated with lamotrigine.Material and methodsThis open study included 141 patients treated with lamotrigine for a period of 8 months: 79 patients initiated treatment with lamotrigine monotherapy, and 62 were switched to lamotrigine because of lack of efficacy or adverse events to a previous antiepileptic drug (AED). Patients were assessed at baseline and after 4 and 8 months of treatment. In the baseline and final visits the Changes in Sexual Functioning Questionnaire (CSFQ) was applied. Analysis was performed in an intent-to-treat population.ResultsIn women who started treatment with lamotrigine, a significant improvement was observed, both in total CSFQ score (increase of 5.39 ± 6.95 points; p < 0.05), and in the five dimensions of the scale (desire/frequency, desire/interest, pleasure, arousal/excitement and orgasm). In men, a significant improvement was only observed in the pleasure dimension. In the group of patients in whom a previous AED was substituted by lamotrigine, significant improvement was recorded in the dimensions of pleasure and orgasm in men and desire/frequency in women, whilst in women the desire/interest dimension showed a decrease.ConclusionsIn this observational study, an improvement in sexual dysfunction was observed in association with lamotrigine. This could have been the result of improvement of the epilepsy, changes in quality of life, elimination of side effects from other AEDs, or a mood-stabilizing effect of lamotrigine." @default.
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• W2012619962 date "2006-04-01" @default.
• W2012619962 modified "2023-10-18" @default.
• W2012619962 title "Effect of lamotrigine on sexual function in patients with epilepsy" @default.
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• W2012619962 doi "https://doi.org/10.1016/j.seizure.2005.12.006" @default.
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