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- W2012631983 abstract "Abstract The prostaglandins (PGs) are involved in various mammalian female reproductive processes including ovulation, fertilization, luteolysis, and uterine contraction. To determine which specific PG and receptor subtype are crucial for each of the reproductive processes, we generated PG receptor-deficient mice. Among the eight types of PG receptors, only the PGF2α receptor FP-deficient and PGE2 receptor subtype EP2-deficient mice exhibited a failure of parturition and a decrease in litter size, respectively. FP-deficient mice failed to show both the up-regulation of the oxytocin receptor in uterine tissues at term and the prepartum decline in serum progesterone levels, indicating that PGF2α is essential for the induction of parturition via its luteolytic activity. Furthermore, expression analyses of the cyclooxygenases (COXs) suggested that the COX-2 isozyme in the myometrium at term is responsible for producing uterotonic PGs. On the other hand, EP2-deficient female mice consistently delivered fewer pups than their wild-type counterparts. They showed phenotypes of slightly impaired ovulation and a dramatic reduction in fertilization due to impaired expansion of the cumulus cells, indicating that PGE2 plays a role in ovulation and fertilization by inducing cumulus expansion via the EP2 receptor. These results show that PGE2 and PGF2α play important roles in the mouse physiological reproduction processes." @default.
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- W2012631983 date "2002-11-01" @default.
- W2012631983 modified "2023-09-27" @default.
- W2012631983 title "Prostaglandin E2 and F2α in mouse reproduction" @default.
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- W2012631983 doi "https://doi.org/10.1016/s0531-5131(02)00160-7" @default.
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