FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012651092> ?p ?o ?g. }

• W2012651092 endingPage "332" @default.
• W2012651092 startingPage "324" @default.
• W2012651092 abstract "Endothelins (ETs) promote cytoskeletal actin reorganization of cultured astrocytes (Koyama and Baba, Neuroscience 61:1007–1016, 1994; Koyama and Baba, Glia 16:342–350, 1996). In this study, we examined the signal transduction involved in that activity of ETs. Immunoblot analysis with an anti-phosphotyrosine antibody showed that ET-3 (1 nM) increased tyrosine phosphorylation of 120 Kda and 70 Kda astrocytic proteins. The tyrosine phosphorylations of both proteins reached a maximum at 1 nM ET-3. In morphological examinations, ET-3 (1 nM) induced stress fibers, an organized F-actin structure, and focal adhesions in 0.5 mM dibutyryl cAMP (DBcAMP)-treated astrocytes within 30 min. Immunochemical staining of phosphotyrosine revealed that the newly formed focal adhesions possessed phosphotyrosine immunoreactivity. Phorbol 12-myristate 13 acetate (PMA,100 nM), bradykinin (1 μM), angiotensin II (100 nM), and A23187 (5 μM) did not induce astrocytic stress fibers and had no obvious effects on tyrosine phosphorylation of 120 Kda and 70 Kda proteins. Tyrosine phosphorylation of astrocytic 120 Kda and 70 Kda proteins was stimulated by 1 mM sodium orthovanadate (VO43−), a protein tyrosine phosphatase inhibitor. VO43− promoted reorganization of stress fibers and focal adhesions in DBcAMP-treated astrocytes. Neither chelation of intra- and extracellular Ca2+ nor pre-treatment with pertussis toxin (PTX) affected the ET-induced tyrosine phosphorylation and stress fiber formation in cultured astrocytes. These results suggest a relationship between cytoskeletal actin reorganization and the tyrosine phosphorylation of astrocytic proteins by ETs. GLIA 26:324–332, 1999. © 1999 Wiley-Liss, Inc." @default.
• W2012651092 created "2016-06-24" @default.
• W2012651092 creator A5069871672 @default.
• W2012651092 creator A5091267274 @default.
• W2012651092 date "1999-06-01" @default.
• W2012651092 modified "2023-10-18" @default.
• W2012651092 title "Endothelin-induced protein tyrosine phosphorylation of cultured astrocytes: Its relationship to cytoskeletal actin organization" @default.
• W2012651092 cites W1513266031 @default.
• W2012651092 cites W1540746382 @default.
• W2012651092 cites W1592758533 @default.
• W2012651092 cites W1605575463 @default.
• W2012651092 cites W1669532073 @default.
• W2012651092 cites W1744354425 @default.
• W2012651092 cites W1966210349 @default.
• W2012651092 cites W1977162373 @default.
• W2012651092 cites W1983650913 @default.
• W2012651092 cites W1984621868 @default.
• W2012651092 cites W1987308911 @default.
• W2012651092 cites W1994138436 @default.
• W2012651092 cites W2003470531 @default.
• W2012651092 cites W2006207066 @default.
• W2012651092 cites W2006289803 @default.
• W2012651092 cites W2007660746 @default.
• W2012651092 cites W2014350166 @default.
• W2012651092 cites W20218504 @default.
• W2012651092 cites W2023800215 @default.
• W2012651092 cites W2045649260 @default.
• W2012651092 cites W2054473433 @default.
• W2012651092 cites W2055588106 @default.
• W2012651092 cites W2057679215 @default.
• W2012651092 cites W2061708109 @default.
• W2012651092 cites W2063102080 @default.
• W2012651092 cites W2070086285 @default.
• W2012651092 cites W2075610981 @default.
• W2012651092 cites W2090498529 @default.
• W2012651092 cites W2094645760 @default.
• W2012651092 cites W2140148086 @default.
• W2012651092 cites W2141445328 @default.
• W2012651092 cites W2148849095 @default.
• W2012651092 cites W2223326463 @default.
• W2012651092 cites W2321309748 @default.
• W2012651092 cites W4242913751 @default.
• W2012651092 doi "https://doi.org/10.1002/(sici)1098-1136(199906)26:4<324::aid-glia6>3.0.co;2-x" @default.
• W2012651092 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10383051" @default.
• W2012651092 hasPublicationYear "1999" @default.
• W2012651092 type Work @default.
• W2012651092 sameAs 2012651092 @default.
• W2012651092 citedByCount "13" @default.
• W2012651092 countsByYear W20126510922013 @default.
• W2012651092 countsByYear W20126510922014 @default.
• W2012651092 countsByYear W20126510922021 @default.
• W2012651092 crossrefType "journal-article" @default.
• W2012651092 hasAuthorship W2012651092A5069871672 @default.
• W2012651092 hasAuthorship W2012651092A5091267274 @default.
• W2012651092 hasConcept C11960822 @default.
• W2012651092 hasConcept C134018914 @default.
• W2012651092 hasConcept C142669718 @default.
• W2012651092 hasConcept C1491633281 @default.
• W2012651092 hasConcept C151166631 @default.
• W2012651092 hasConcept C153911025 @default.
• W2012651092 hasConcept C2776165026 @default.
• W2012651092 hasConcept C2777542381 @default.
• W2012651092 hasConcept C2777553839 @default.
• W2012651092 hasConcept C2781099445 @default.
• W2012651092 hasConcept C529278444 @default.
• W2012651092 hasConcept C55493867 @default.
• W2012651092 hasConcept C85528070 @default.
• W2012651092 hasConcept C86803240 @default.
• W2012651092 hasConcept C95444343 @default.
• W2012651092 hasConceptScore W2012651092C11960822 @default.
• W2012651092 hasConceptScore W2012651092C134018914 @default.
• W2012651092 hasConceptScore W2012651092C142669718 @default.
• W2012651092 hasConceptScore W2012651092C1491633281 @default.
• W2012651092 hasConceptScore W2012651092C151166631 @default.
• W2012651092 hasConceptScore W2012651092C153911025 @default.
• W2012651092 hasConceptScore W2012651092C2776165026 @default.
• W2012651092 hasConceptScore W2012651092C2777542381 @default.
• W2012651092 hasConceptScore W2012651092C2777553839 @default.
• W2012651092 hasConceptScore W2012651092C2781099445 @default.
• W2012651092 hasConceptScore W2012651092C529278444 @default.
• W2012651092 hasConceptScore W2012651092C55493867 @default.
• W2012651092 hasConceptScore W2012651092C85528070 @default.
• W2012651092 hasConceptScore W2012651092C86803240 @default.
• W2012651092 hasConceptScore W2012651092C95444343 @default.
• W2012651092 hasIssue "4" @default.
• W2012651092 hasLocation W20126510921 @default.
• W2012651092 hasLocation W20126510922 @default.
• W2012651092 hasOpenAccess W2012651092 @default.
• W2012651092 hasPrimaryLocation W20126510921 @default.
• W2012651092 hasRelatedWork W1580168755 @default.
• W2012651092 hasRelatedWork W2002806430 @default.
• W2012651092 hasRelatedWork W2027197074 @default.
• W2012651092 hasRelatedWork W2027995286 @default.
• W2012651092 hasRelatedWork W2040534221 @default.
• W2012651092 hasRelatedWork W2059203064 @default.
• W2012651092 hasRelatedWork W2085026676 @default.
• W2012651092 hasRelatedWork W2089643790 @default.
• W2012651092 hasRelatedWork W2183062661 @default.

• next