Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012652015> ?p ?o ?g. }
- W2012652015 endingPage "3900" @default.
- W2012652015 startingPage "3895" @default.
- W2012652015 abstract "ABSTRACT Among men with febrile urinary tract infection (FUTI), whether the host's fecal flora is the source for the urine strain (“fecal-urethral” hypothesis), and whether pathogenesis is driven by prevalence versus special pathogenicity, are unknown. Accordingly, pretherapy urine isolates from 65 men with FUTI were compared with concurrent rectal isolates from the same hosts according to serotype, genomic profile, phylogenetic group, and virulence genotype. The host's multiple rectal colonies included only the urine clone in 25% of subjects, the urine clone plus additional clones in 22%, and only nonurine clones in 54%. Compared with the 67 unique rectal clones, the 65 urine isolates were significantly enriched for phylogenetic group B2, virulence-associated serotypes, and specific virulence genes and contained more virulence genes (median, 10 versus 6: P < 0.001). In multivariable models, phylogenetic group B2, hlyD (hemolysin), cnf1 (cytotoxic necrotizing factor), iroN (siderophore receptor), ompT (outer membrane protease), and malX (pathogenicity island marker) most strongly predicted urine source. These findings challenge the fecal-urethral and prevalence hypotheses for FUTI pathogenesis and instead strongly support the possibility of alternate infection routes in some men and the special pathogenicity hypothesis. They also identify specific bacterial traits as potential targets for anti-FUTI interventions." @default.
- W2012652015 created "2016-06-24" @default.
- W2012652015 creator A5001360393 @default.
- W2012652015 creator A5004537249 @default.
- W2012652015 creator A5017325663 @default.
- W2012652015 creator A5025115465 @default.
- W2012652015 creator A5034386514 @default.
- W2012652015 creator A5060867081 @default.
- W2012652015 date "2005-08-01" @default.
- W2012652015 modified "2023-09-25" @default.
- W2012652015 title "Phylogenetic and Pathotypic Comparison of Concurrent Urine and Rectal <i>Escherichia coli</i> Isolates from Men with Febrile Urinary Tract Infection" @default.
- W2012652015 cites W143694616 @default.
- W2012652015 cites W1550988344 @default.
- W2012652015 cites W1584839411 @default.
- W2012652015 cites W1955612312 @default.
- W2012652015 cites W1965322093 @default.
- W2012652015 cites W1988637458 @default.
- W2012652015 cites W1989204224 @default.
- W2012652015 cites W1997839985 @default.
- W2012652015 cites W2013333787 @default.
- W2012652015 cites W2014298338 @default.
- W2012652015 cites W2015012077 @default.
- W2012652015 cites W2023683042 @default.
- W2012652015 cites W2024007545 @default.
- W2012652015 cites W2028485131 @default.
- W2012652015 cites W2033383943 @default.
- W2012652015 cites W2037049920 @default.
- W2012652015 cites W2040169459 @default.
- W2012652015 cites W2057550147 @default.
- W2012652015 cites W2060297877 @default.
- W2012652015 cites W2060421393 @default.
- W2012652015 cites W2094448747 @default.
- W2012652015 cites W2099197531 @default.
- W2012652015 cites W2101883747 @default.
- W2012652015 cites W2104926496 @default.
- W2012652015 cites W2107533276 @default.
- W2012652015 cites W2116717564 @default.
- W2012652015 cites W2117590461 @default.
- W2012652015 cites W2117944021 @default.
- W2012652015 cites W2119464507 @default.
- W2012652015 cites W2127146104 @default.
- W2012652015 cites W2127512232 @default.
- W2012652015 cites W2136698980 @default.
- W2012652015 cites W2138139644 @default.
- W2012652015 cites W2145453521 @default.
- W2012652015 cites W2153139855 @default.
- W2012652015 cites W2153374031 @default.
- W2012652015 cites W2158682148 @default.
- W2012652015 cites W2164571390 @default.
- W2012652015 cites W2166110740 @default.
- W2012652015 cites W2172234175 @default.
- W2012652015 cites W2337712693 @default.
- W2012652015 cites W4302897077 @default.
- W2012652015 cites W977140592 @default.
- W2012652015 doi "https://doi.org/10.1128/jcm.43.8.3895-3900.2005" @default.
- W2012652015 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1233927" @default.
- W2012652015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16081928" @default.
- W2012652015 hasPublicationYear "2005" @default.
- W2012652015 type Work @default.
- W2012652015 sameAs 2012652015 @default.
- W2012652015 citedByCount "54" @default.
- W2012652015 countsByYear W20126520152012 @default.
- W2012652015 countsByYear W20126520152013 @default.
- W2012652015 countsByYear W20126520152014 @default.
- W2012652015 countsByYear W20126520152015 @default.
- W2012652015 countsByYear W20126520152016 @default.
- W2012652015 countsByYear W20126520152017 @default.
- W2012652015 countsByYear W20126520152018 @default.
- W2012652015 countsByYear W20126520152019 @default.
- W2012652015 countsByYear W20126520152020 @default.
- W2012652015 crossrefType "journal-article" @default.
- W2012652015 hasAuthorship W2012652015A5001360393 @default.
- W2012652015 hasAuthorship W2012652015A5004537249 @default.
- W2012652015 hasAuthorship W2012652015A5017325663 @default.
- W2012652015 hasAuthorship W2012652015A5025115465 @default.
- W2012652015 hasAuthorship W2012652015A5034386514 @default.
- W2012652015 hasAuthorship W2012652015A5060867081 @default.
- W2012652015 hasBestOaLocation W20126520152 @default.
- W2012652015 hasConcept C10389963 @default.
- W2012652015 hasConcept C104317684 @default.
- W2012652015 hasConcept C135763542 @default.
- W2012652015 hasConcept C159047783 @default.
- W2012652015 hasConcept C193252679 @default.
- W2012652015 hasConcept C203014093 @default.
- W2012652015 hasConcept C2780026642 @default.
- W2012652015 hasConcept C2780942790 @default.
- W2012652015 hasConcept C54355233 @default.
- W2012652015 hasConcept C55493867 @default.
- W2012652015 hasConcept C60987743 @default.
- W2012652015 hasConcept C61716771 @default.
- W2012652015 hasConcept C62130838 @default.
- W2012652015 hasConcept C86803240 @default.
- W2012652015 hasConcept C89423630 @default.
- W2012652015 hasConceptScore W2012652015C10389963 @default.
- W2012652015 hasConceptScore W2012652015C104317684 @default.
- W2012652015 hasConceptScore W2012652015C135763542 @default.
- W2012652015 hasConceptScore W2012652015C159047783 @default.
- W2012652015 hasConceptScore W2012652015C193252679 @default.