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• W2012655151 abstract "Although bacteraemia has been reported to be related to false positive results in the 1,3-beta-d-glucan (BDG) test, the evidence for this interaction is limited. To investigate the association between bacteraemia and the BDG test. Records of the Infection Control Committee were reviewed to identify bacteraemia in patients who were hospitalized in the haematology ward and stem cell transplantation unit. Patients who had undergone the BDG test at least once within 5 days of a positive blood culture were included in the study. BDG levels in the sera were assayed using the Fungitell kit (Associates of Cape Cod, East Falmouth, MA) according to the manufacturer's specifications. The cutoff for BDG positivity was 80 pg/mL. Eighty-three bacteraemic episodes were identified in 71 patients. BDG positivity was detected in 14 patients with bacteraemia, and only 1 patient with Escherichia coli bacteraemia had high BDG levels (over 80 pg/mL) despite having no evidence of invasive fungal infection (IFI). Our study suggests that the cross-reactivity of the BDG test with a concomitant or recent bacteraemia is a very rare condition. Patients with risk factors for IFI should be evaluated cautiously when a positive BDG test is reported. Aunque se ha descrito que la bacteriemia se relaciona con resultados falsos positivos en la determinación de 1,3-beta-d-glucano (BDG), las pruebas de esta interacción son limitadas. El objetivo de este estudio fue investigar la asociación entre la bacteriemia y la determinación de BDG. Para identificar a los pacientes con bacteriemia hospitalizados en la sala de hematología y la unidad de trasplante de células progenitoras, se revisaron los archivos de historias clínicas del comité de control de infecciones. En el estudio se incluyeron a los pacientes sometidos como mínimo a una determinación de BDG al cabo de 5 días de un resultado positivo del hemocultivo. La determinación de los valores séricos de BDG se analizó con el test Fungitell (Associates of Cape Cod, East Falmouth, MA, EE. UU.), de acuerdo con las especificaciones del fabricante. El punto de corte para la determinación de un resultado positivo se estableció en 80 pg/mL. Se identificó un total de 83 episodios de bacteriemia en 71 pacientes. En 14 de ellos, la determinación de BDG fue positiva, pero sólo se identificaron valores elevados en un paciente con bacteriemia por Escherichia coli (>80 pg/mL), a pesar de que no se detectaron pruebas de infección fúngica invasora (IFI). Los resultados del presente estudio sugieren que la reactividad cruzada entre la determinación de BDG y con una bacteriemia concomitante o reciente es excepcional. Cuando se documenten resultados positivos de la determinación de BDG, es preciso valorar con precaución a los pacientes con factores de riesgo de IFI." @default.
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• W2012655151 date "2012-07-01" @default.
• W2012655151 modified "2023-10-16" @default.
• W2012655151 title "Can bacteraemia lead to false positive results in 1,3-beta-d-glucan test? Analysis of 83 bacteraemia episodes in high-risk patients for invasive fungal infections" @default.
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• W2012655151 doi "https://doi.org/10.1016/j.riam.2011.07.003" @default.
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