Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012667224> ?p ?o ?g. }
- W2012667224 endingPage "E1009" @default.
- W2012667224 startingPage "E1000" @default.
- W2012667224 abstract "We have previously shown that a decrease in γ-aminobutyric acid (GABA) tone and a subsequent increase in glutamatergic tone occur in association with the pubertal increase in luteinizing hormone releasing hormone (LHRH) release in primates. To further determine the causal relationship between developmental changes in GABA and glutamate levels and the pubertal increase in LHRH release, we examined monkeys with precocious puberty induced by lesions in the posterior hypothalamus (PH). Six prepubertal female rhesus monkeys (17.4 ± 0.1 mo of age) received lesions in the PH, three prepubertal females (17.5 ± 0.1 mo) received sham lesions, and two females received no treatments. LHRH, GABA, and glutamate levels in the stalk-median eminence before and after lesions were assessed over two 6-h periods (0600–1200 and 1800–2400) using push-pull perfusion. Monkeys with PH lesions exhibited external signs of precocious puberty, including significantly earlier menarche in PH lesion animals (18.8 ± 0.2 mo) than in sham/controls (25.5 ± 0.9 mo, P < 0.001). Moreover, PH lesion animals had elevated LHRH levels and higher evening glutamate levels after lesions, whereas LHRH changes did not occur in sham/controls until later. Changes in GABA release were not discernible, since evening GABA levels already deceased at 18–20 mo of age in both groups and morning levels remained at the prepubertal levels. The age of first ovulation in both groups did not differ. Collectively, PH lesions may not be a good tool to investigate the mechanism of puberty, and, taking into account the recent findings on the role of kisspeptins, the mechanism of the puberty onset in primates is more complex than we initially anticipated." @default.
- W2012667224 created "2016-06-24" @default.
- W2012667224 creator A5048709003 @default.
- W2012667224 creator A5053366148 @default.
- W2012667224 creator A5061445584 @default.
- W2012667224 creator A5066397340 @default.
- W2012667224 creator A5069619841 @default.
- W2012667224 date "2007-04-01" @default.
- W2012667224 modified "2023-09-24" @default.
- W2012667224 title "An increase in in vivo release of LHRH and precocious puberty by posterior hypothalamic lesions in female rhesus monkeys (Macaca mulatta)" @default.
- W2012667224 cites W1651337007 @default.
- W2012667224 cites W1819254522 @default.
- W2012667224 cites W1936724401 @default.
- W2012667224 cites W1969311327 @default.
- W2012667224 cites W1981402761 @default.
- W2012667224 cites W1991384037 @default.
- W2012667224 cites W1994128809 @default.
- W2012667224 cites W1999222898 @default.
- W2012667224 cites W2003794280 @default.
- W2012667224 cites W2006381764 @default.
- W2012667224 cites W2018207400 @default.
- W2012667224 cites W2018363136 @default.
- W2012667224 cites W2018378087 @default.
- W2012667224 cites W2026233018 @default.
- W2012667224 cites W2043404406 @default.
- W2012667224 cites W2045690475 @default.
- W2012667224 cites W2048872158 @default.
- W2012667224 cites W2054677249 @default.
- W2012667224 cites W2059613653 @default.
- W2012667224 cites W2059917807 @default.
- W2012667224 cites W2066104572 @default.
- W2012667224 cites W2068391832 @default.
- W2012667224 cites W2074964096 @default.
- W2012667224 cites W2077309499 @default.
- W2012667224 cites W2079595516 @default.
- W2012667224 cites W2080692154 @default.
- W2012667224 cites W2082333255 @default.
- W2012667224 cites W2083342669 @default.
- W2012667224 cites W2086331746 @default.
- W2012667224 cites W2093606839 @default.
- W2012667224 cites W2096633132 @default.
- W2012667224 cites W2097632502 @default.
- W2012667224 cites W2098285721 @default.
- W2012667224 cites W2106367039 @default.
- W2012667224 cites W2112523966 @default.
- W2012667224 cites W2112937918 @default.
- W2012667224 cites W2115310479 @default.
- W2012667224 cites W2132206421 @default.
- W2012667224 cites W2144387105 @default.
- W2012667224 cites W2151265888 @default.
- W2012667224 cites W2160721561 @default.
- W2012667224 cites W2164194706 @default.
- W2012667224 cites W2171036048 @default.
- W2012667224 cites W2235704951 @default.
- W2012667224 cites W4251190215 @default.
- W2012667224 cites W4251664158 @default.
- W2012667224 cites W64292903 @default.
- W2012667224 cites W94268043 @default.
- W2012667224 doi "https://doi.org/10.1152/ajpendo.00493.2006" @default.
- W2012667224 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2203965" @default.
- W2012667224 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17148755" @default.
- W2012667224 hasPublicationYear "2007" @default.
- W2012667224 type Work @default.
- W2012667224 sameAs 2012667224 @default.
- W2012667224 citedByCount "7" @default.
- W2012667224 countsByYear W20126672242012 @default.
- W2012667224 countsByYear W20126672242015 @default.
- W2012667224 countsByYear W20126672242016 @default.
- W2012667224 crossrefType "journal-article" @default.
- W2012667224 hasAuthorship W2012667224A5048709003 @default.
- W2012667224 hasAuthorship W2012667224A5053366148 @default.
- W2012667224 hasAuthorship W2012667224A5061445584 @default.
- W2012667224 hasAuthorship W2012667224A5066397340 @default.
- W2012667224 hasAuthorship W2012667224A5069619841 @default.
- W2012667224 hasBestOaLocation W20126672242 @default.
- W2012667224 hasConcept C118552586 @default.
- W2012667224 hasConcept C121332964 @default.
- W2012667224 hasConcept C126322002 @default.
- W2012667224 hasConcept C1276947 @default.
- W2012667224 hasConcept C134018914 @default.
- W2012667224 hasConcept C170493617 @default.
- W2012667224 hasConcept C19720800 @default.
- W2012667224 hasConcept C2776476923 @default.
- W2012667224 hasConcept C2777003273 @default.
- W2012667224 hasConcept C2777702977 @default.
- W2012667224 hasConcept C2778367240 @default.
- W2012667224 hasConcept C2778575703 @default.
- W2012667224 hasConcept C2778894405 @default.
- W2012667224 hasConcept C2779067335 @default.
- W2012667224 hasConcept C2781156865 @default.
- W2012667224 hasConcept C61174792 @default.
- W2012667224 hasConcept C71315377 @default.
- W2012667224 hasConcept C71924100 @default.
- W2012667224 hasConcept C86803240 @default.
- W2012667224 hasConceptScore W2012667224C118552586 @default.
- W2012667224 hasConceptScore W2012667224C121332964 @default.
- W2012667224 hasConceptScore W2012667224C126322002 @default.
- W2012667224 hasConceptScore W2012667224C1276947 @default.