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- W2012671084 abstract "Zinc, the most abundant trace metal in the brain, has numerous functions, both in health and in disease. Zinc is released into the synaptic cleft of glutamatergic neurons alongside glutamate from where it interacts and modulates NMDA and AMPA receptors. In addition, zinc has multifactorial functions in Alzheimer's disease (AD). Zinc is critical in the enzymatic nonamyloidogenic processing of the amyloid precursor protein (APP) and in the enzymatic degradation of the amyloid- β (A β ) peptide. Zinc binds to A β promoting its aggregation into neurotoxic species, and disruption of zinc homeostasis in the brain results in synaptic and memory deficits. Thus, zinc dyshomeostasis may have a critical role to play in the pathogenesis of AD, and the chelation of zinc is a potential therapeutic approach." @default.
- W2012671084 created "2016-06-24" @default.
- W2012671084 creator A5021063040 @default.
- W2012671084 creator A5054814020 @default.
- W2012671084 creator A5091491536 @default.
- W2012671084 date "2011-01-01" @default.
- W2012671084 modified "2023-09-30" @default.
- W2012671084 title "The Role of Zinc in Alzheimer's Disease" @default.
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