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• W2012671657 abstract "Abstract Introduction Poisoning is an infrequent cause of consultation in a paediatric emergency department (PED), but it can be potentially serious. Paediatricians should know how to use the available antidotes properly. Objectives To analyse the use of antidotes in a PED and to assess the suitability of their indications. Materials and methods A retrospective review of antidote use in a PED between January 2008 and June 2012. Inclusion criteria were age younger than 18 years and consultation for suspicious poisoning by a substance that could be treated with an antidote. The adequacy of antidote indication was based on the recommendations of the Spanish Society of Paediatric Emergencies (SSPE). Results A total of 1728 consultations for suspicious poisoning (0.4% of the total visits in the PED) were recorded. In 353 cases (20.4%) the involved poison could be treated with an antidote. Sixty-seven patients received an antidote (3.9% of consultations for suspicious poisoning), and a total of 69 administrations of an antidote were made: 100% oxygen (46), N-acetylcysteine (10), flumazenil (4), naloxone (3), deferoxamine (2), vitamin K (2), bicarbonate (1), and carnitine (1). In three cases there was no indication for administration: flumazenil without respiratory depression, and vitamin K following coumarin exposure. As side effects, agitation was noted after the use of flumazenil, and a decrease in the prothrombin time during infusion of N-acetylcysteine. Conclusions The administration of antidotes in this PED is uncommon and, mainly, in accordance with the SSPE recommendations, and without serious side effects. The use of flumazenil needs to be limited to the cases with a clear indication and without any contraindication." @default.
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• W2012671657 date "2014-10-01" @default.
• W2012671657 modified "2023-09-26" @default.
• W2012671657 title "Antidote use in a paediatric emergency department" @default.
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• W2012671657 doi "https://doi.org/10.1016/j.anpede.2013.12.002" @default.
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