Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012674174> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2012674174 endingPage "A246" @default.
- W2012674174 startingPage "A245.2" @default.
- W2012674174 abstract "<h3>Introduction</h3> Degree of hepatocellular injury, necrosis/apoptosis and inflammation may be assessed by the serum markers that reflect the pathogenic process. We investigated the correlation of circulating miR-122, High Mobility Group Box-1 (HMGB1), soluble Fas (sFas) and caspase-cleaved fragment of keratin-18 (CK18) with histological changes in liver biopsy of patients with non-alcoholic fatty liver disease (NAFLD). <h3>Methods</h3> Serum analytes were determined in two independent cohorts of patients with NAFLD (derivation cohort n = 165, validation cohort n = 101). Histological parameters were scored using Clinical Research Network system; patients with NAFLD activity scores (NAS) of ≥3 were classified as borderline non-alcoholic steatohepatitis (NASH) and ≥ 5 as definite NASH. <h3>Results</h3> There were no significant differences in miR-122, HMGB1, sFas and CK18 M30 levels between those with low (0–2) and high (3–4) stage of fibrosis. Both CK18 M30 as well as CK18 M65 correlated with grades of ballooning (p = 0.003 and p = 0.001) and lobular inflammation (p = 0.006 and p = 0.001). Table 1 summarises the serum levels of all the evaluated markers in subgroups of patients classified as borderline or definite NASH when only patients with low grade fibrosis were included (derivation cohort, n = 145 and validation cohort, n = 90). Importantly, when the cut-off values for CK18 M30 (395 U/L) was used on its own, 57/86 (66%) patients with definite NASH were missed. <h3>Conclusion</h3> Biomarkers, UKof cell injury and death in combination have a potential to detect on-going histological activity in NAFLD. <h3>Disclosure of Interest</h3> None Declared." @default.
- W2012674174 created "2016-06-24" @default.
- W2012674174 creator A5011136979 @default.
- W2012674174 creator A5016627269 @default.
- W2012674174 creator A5020449397 @default.
- W2012674174 creator A5025440893 @default.
- W2012674174 creator A5028984020 @default.
- W2012674174 creator A5029602513 @default.
- W2012674174 creator A5034220569 @default.
- W2012674174 creator A5047002446 @default.
- W2012674174 creator A5052811033 @default.
- W2012674174 creator A5058792054 @default.
- W2012674174 creator A5059961083 @default.
- W2012674174 creator A5080629259 @default.
- W2012674174 date "2014-06-01" @default.
- W2012674174 modified "2023-09-27" @default.
- W2012674174 title "PTH-082 Do Serum Markers Of Cell Injury And Death Have Potential To Become Mechanistic Markers In Non-alcoholic Fatty Liver Disease (nafld)?: Abstract PTH-082 Table 1" @default.
- W2012674174 doi "https://doi.org/10.1136/gutjnl-2014-307263.528" @default.
- W2012674174 hasPublicationYear "2014" @default.
- W2012674174 type Work @default.
- W2012674174 sameAs 2012674174 @default.
- W2012674174 citedByCount "2" @default.
- W2012674174 countsByYear W20126741742017 @default.
- W2012674174 countsByYear W20126741742018 @default.
- W2012674174 crossrefType "journal-article" @default.
- W2012674174 hasAuthorship W2012674174A5011136979 @default.
- W2012674174 hasAuthorship W2012674174A5016627269 @default.
- W2012674174 hasAuthorship W2012674174A5020449397 @default.
- W2012674174 hasAuthorship W2012674174A5025440893 @default.
- W2012674174 hasAuthorship W2012674174A5028984020 @default.
- W2012674174 hasAuthorship W2012674174A5029602513 @default.
- W2012674174 hasAuthorship W2012674174A5034220569 @default.
- W2012674174 hasAuthorship W2012674174A5047002446 @default.
- W2012674174 hasAuthorship W2012674174A5052811033 @default.
- W2012674174 hasAuthorship W2012674174A5058792054 @default.
- W2012674174 hasAuthorship W2012674174A5059961083 @default.
- W2012674174 hasAuthorship W2012674174A5080629259 @default.
- W2012674174 hasBestOaLocation W20126741741 @default.
- W2012674174 hasConcept C126322002 @default.
- W2012674174 hasConcept C142724271 @default.
- W2012674174 hasConcept C2775934546 @default.
- W2012674174 hasConcept C2777766500 @default.
- W2012674174 hasConcept C2778772119 @default.
- W2012674174 hasConcept C2779134260 @default.
- W2012674174 hasConcept C2779478299 @default.
- W2012674174 hasConcept C2780559512 @default.
- W2012674174 hasConcept C71924100 @default.
- W2012674174 hasConcept C72563966 @default.
- W2012674174 hasConcept C90924648 @default.
- W2012674174 hasConceptScore W2012674174C126322002 @default.
- W2012674174 hasConceptScore W2012674174C142724271 @default.
- W2012674174 hasConceptScore W2012674174C2775934546 @default.
- W2012674174 hasConceptScore W2012674174C2777766500 @default.
- W2012674174 hasConceptScore W2012674174C2778772119 @default.
- W2012674174 hasConceptScore W2012674174C2779134260 @default.
- W2012674174 hasConceptScore W2012674174C2779478299 @default.
- W2012674174 hasConceptScore W2012674174C2780559512 @default.
- W2012674174 hasConceptScore W2012674174C71924100 @default.
- W2012674174 hasConceptScore W2012674174C72563966 @default.
- W2012674174 hasConceptScore W2012674174C90924648 @default.
- W2012674174 hasIssue "Suppl 1" @default.
- W2012674174 hasLocation W20126741741 @default.
- W2012674174 hasLocation W20126741742 @default.
- W2012674174 hasOpenAccess W2012674174 @default.
- W2012674174 hasPrimaryLocation W20126741741 @default.
- W2012674174 hasRelatedWork W172225683 @default.
- W2012674174 hasRelatedWork W1975489439 @default.
- W2012674174 hasRelatedWork W2036698572 @default.
- W2012674174 hasRelatedWork W2086939368 @default.
- W2012674174 hasRelatedWork W2576488295 @default.
- W2012674174 hasRelatedWork W2701978336 @default.
- W2012674174 hasRelatedWork W2801504120 @default.
- W2012674174 hasRelatedWork W2990608729 @default.
- W2012674174 hasRelatedWork W3215462966 @default.
- W2012674174 hasRelatedWork W4362700370 @default.
- W2012674174 hasVolume "63" @default.
- W2012674174 isParatext "false" @default.
- W2012674174 isRetracted "false" @default.
- W2012674174 magId "2012674174" @default.
- W2012674174 workType "article" @default.