Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012677936> ?p ?o ?g. }
- W2012677936 endingPage "36" @default.
- W2012677936 startingPage "31" @default.
- W2012677936 abstract "It is well known that the enteric nervous system (ENS) regulates the movement and function of the small intestine, but the effects of ENS on drug absorption from the small intestine still remain to be clarified. Focusing on adrenergic effect, we tried to evaluate how adrenergic stimulation influences the drug absorption via passive diffusion using Caco-2 cells as model epithelial cells, a terminal effector of ENS. Adrenaline, an adrenergic agonist, did not affect the transport of small molecules such as antipyrine, phenacetin and mannitol, but decreased the transport of large molecules such as FITC-dextran (FD)-20 and FD-40 without transepithelial electrical resistance (TEER) change. These results suggested that the transport of large molecules via paracellular route would be attenuated by adrenergic stimulation. Only clonidine, an alpha(2)-agonist, among selective adrenoceptor agonists decreased FD-40 transport across Caco-2 cell monolayers and the agonist also decreased intracellular cAMP. Furthermore, H-89, a protein kinase A inhibitor, significantly decreased FD-40 transport and dibutyryl cAMP, a cAMP derivative, increased it. These results suggest that the decrease in FD-40 transport would be mainly attributed to the decrease in intracellular cAMP and subsequent decrease in PKA activity via alpha(2)-receptor stimulation." @default.
- W2012677936 created "2016-06-24" @default.
- W2012677936 creator A5019436239 @default.
- W2012677936 creator A5030971021 @default.
- W2012677936 creator A5033861263 @default.
- W2012677936 creator A5064755910 @default.
- W2012677936 creator A5085916499 @default.
- W2012677936 creator A5089829213 @default.
- W2012677936 date "2009-02-01" @default.
- W2012677936 modified "2023-09-27" @default.
- W2012677936 title "Effect of adrenergic stimulation on drug absorption via passive diffusion in Caco-2 cells" @default.
- W2012677936 cites W1555960510 @default.
- W2012677936 cites W1589010135 @default.
- W2012677936 cites W1851651927 @default.
- W2012677936 cites W1860914887 @default.
- W2012677936 cites W1967699571 @default.
- W2012677936 cites W1975929650 @default.
- W2012677936 cites W1975983454 @default.
- W2012677936 cites W1990736267 @default.
- W2012677936 cites W1998004742 @default.
- W2012677936 cites W1999563077 @default.
- W2012677936 cites W2006272697 @default.
- W2012677936 cites W2012193274 @default.
- W2012677936 cites W2014297898 @default.
- W2012677936 cites W2019829561 @default.
- W2012677936 cites W2023009726 @default.
- W2012677936 cites W2028766433 @default.
- W2012677936 cites W2045520426 @default.
- W2012677936 cites W2046636610 @default.
- W2012677936 cites W2060896627 @default.
- W2012677936 cites W2063034638 @default.
- W2012677936 cites W2068406006 @default.
- W2012677936 cites W2070409051 @default.
- W2012677936 cites W2071700498 @default.
- W2012677936 cites W2077326734 @default.
- W2012677936 cites W2085420542 @default.
- W2012677936 cites W2087896459 @default.
- W2012677936 cites W2098267014 @default.
- W2012677936 cites W2128077096 @default.
- W2012677936 cites W2140929617 @default.
- W2012677936 cites W2150145465 @default.
- W2012677936 cites W2164629460 @default.
- W2012677936 cites W2170464608 @default.
- W2012677936 cites W2180104880 @default.
- W2012677936 cites W4240918586 @default.
- W2012677936 cites W4244706493 @default.
- W2012677936 cites W4250268503 @default.
- W2012677936 cites W53829816 @default.
- W2012677936 doi "https://doi.org/10.1016/j.ijpharm.2008.09.050" @default.
- W2012677936 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18977284" @default.
- W2012677936 hasPublicationYear "2009" @default.
- W2012677936 type Work @default.
- W2012677936 sameAs 2012677936 @default.
- W2012677936 citedByCount "13" @default.
- W2012677936 countsByYear W20126779362012 @default.
- W2012677936 countsByYear W20126779362013 @default.
- W2012677936 countsByYear W20126779362014 @default.
- W2012677936 countsByYear W20126779362016 @default.
- W2012677936 countsByYear W20126779362018 @default.
- W2012677936 countsByYear W20126779362021 @default.
- W2012677936 countsByYear W20126779362022 @default.
- W2012677936 countsByYear W20126779362023 @default.
- W2012677936 crossrefType "journal-article" @default.
- W2012677936 hasAuthorship W2012677936A5019436239 @default.
- W2012677936 hasAuthorship W2012677936A5030971021 @default.
- W2012677936 hasAuthorship W2012677936A5033861263 @default.
- W2012677936 hasAuthorship W2012677936A5064755910 @default.
- W2012677936 hasAuthorship W2012677936A5085916499 @default.
- W2012677936 hasAuthorship W2012677936A5089829213 @default.
- W2012677936 hasConcept C120882062 @default.
- W2012677936 hasConcept C12554922 @default.
- W2012677936 hasConcept C126322002 @default.
- W2012677936 hasConcept C134018914 @default.
- W2012677936 hasConcept C1491633281 @default.
- W2012677936 hasConcept C158453852 @default.
- W2012677936 hasConcept C170493617 @default.
- W2012677936 hasConcept C185592680 @default.
- W2012677936 hasConcept C193176779 @default.
- W2012677936 hasConcept C24998067 @default.
- W2012677936 hasConcept C2778938600 @default.
- W2012677936 hasConcept C2780013391 @default.
- W2012677936 hasConcept C40465926 @default.
- W2012677936 hasConcept C41625074 @default.
- W2012677936 hasConcept C55493867 @default.
- W2012677936 hasConcept C60903277 @default.
- W2012677936 hasConcept C71924100 @default.
- W2012677936 hasConcept C79879829 @default.
- W2012677936 hasConcept C86803240 @default.
- W2012677936 hasConcept C98274493 @default.
- W2012677936 hasConceptScore W2012677936C120882062 @default.
- W2012677936 hasConceptScore W2012677936C12554922 @default.
- W2012677936 hasConceptScore W2012677936C126322002 @default.
- W2012677936 hasConceptScore W2012677936C134018914 @default.
- W2012677936 hasConceptScore W2012677936C1491633281 @default.
- W2012677936 hasConceptScore W2012677936C158453852 @default.
- W2012677936 hasConceptScore W2012677936C170493617 @default.
- W2012677936 hasConceptScore W2012677936C185592680 @default.
- W2012677936 hasConceptScore W2012677936C193176779 @default.