FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012679926> ?p ?o ?g. }

• W2012679926 abstract "Corynebacterium parvum (C. parvum) or stabilized poly I: C complex (poly ICLC) was administered to C57BL/6 mice with malignant gliomas induced by 20-methylcholanthrene. The results were as follows. 1) When C. parvum was administered intracerebrally, growth of the brain tumor was significantly inhibited compared with intraperitoneal administration. Inhibition of tumor growth was obtained in proportion to the dose of C. parvum. Natural cytotoxic (NC) activity of brain mononuclear cells against malignant glioma cells was most enhanced when C. parvum was administered intracerebrally and that of peritoneal exudate cells was most enhanced when it was administered intraperitoneally in a 15 hour 51Cr release assay. Enhanced NC activity of brain mononuclear cells was found to reach a peak 5 days after intracerebral administration, and to depend on the administered dose. 2) When poly ICLC was administered intracerebrally, tumor growth was more inhibited than when it was administered intraperitoneally. Four administrations of poly ICLC at 4-day intervals showed significant inhibition of tumor growth compared with single administration. Enhanced NC activity of brain mononuclear cells against malignant glioma cells was found to reach a peak 1 day after intracerebral administration of poly I:C, and to depend on the frequency of intracerebral administration of poly ICLC. 3) Enhanced NC cells in the brain after administration of C. parvum and poly ICLC were observed mainly in the adherent cell fraction. 4) Tumor cell growth was inhibited when tumor cells were co-cultured with 250 μg/ml of C. parvum, but poly ICLC had no influence on tumor cell growth. 5) Interferon was not induced after intracerebral administration of C. parvum. High titers of interferon were observed after single intracerebral administration of poly ICLC, but much lower titers of interferon were observed after plural administration at 4-day intervals. From these results, it was suggested that local administration of C. parvum or poly ICLC is effective in inhibiting the growth of brain tumors, that natural cytotoxicity of brain mononuclear cells is enhanced by intracerebral administration of C. parvum or poly ICLC with little interaction of interferon, and that there is a possibility of direct cytotoxic effects of C. parvum." @default.
• W2012679926 created "2016-06-24" @default.
• W2012679926 creator A5001538014 @default.
• W2012679926 creator A5026958589 @default.
• W2012679926 creator A5030921201 @default.
• W2012679926 creator A5040776712 @default.
• W2012679926 creator A5050893434 @default.
• W2012679926 creator A5051407681 @default.
• W2012679926 creator A5081649846 @default.
• W2012679926 creator A5083812045 @default.
• W2012679926 date "1983-01-01" @default.
• W2012679926 modified "2023-09-27" @default.
• W2012679926 title "Antitumor Effect of Corynebacterium parvum and poly ICLC on Experimental Brain Tumors" @default.
• W2012679926 cites W1550310038 @default.
• W2012679926 cites W1581668395 @default.
• W2012679926 cites W1914646166 @default.
• W2012679926 cites W1925945293 @default.
• W2012679926 cites W1964264942 @default.
• W2012679926 cites W1974455937 @default.
• W2012679926 cites W1979560728 @default.
• W2012679926 cites W1995028289 @default.
• W2012679926 cites W2024011032 @default.
• W2012679926 cites W2042746044 @default.
• W2012679926 cites W2046715939 @default.
• W2012679926 cites W2055640519 @default.
• W2012679926 cites W2062046847 @default.
• W2012679926 cites W2063975188 @default.
• W2012679926 cites W2066951502 @default.
• W2012679926 cites W2092449294 @default.
• W2012679926 cites W2106059483 @default.
• W2012679926 cites W2164164380 @default.
• W2012679926 doi "https://doi.org/10.2176/nmc.23.841" @default.
• W2012679926 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6201759" @default.
• W2012679926 hasPublicationYear "1983" @default.
• W2012679926 type Work @default.
• W2012679926 sameAs 2012679926 @default.
• W2012679926 citedByCount "0" @default.
• W2012679926 crossrefType "journal-article" @default.
• W2012679926 hasAuthorship W2012679926A5001538014 @default.
• W2012679926 hasAuthorship W2012679926A5026958589 @default.
• W2012679926 hasAuthorship W2012679926A5030921201 @default.
• W2012679926 hasAuthorship W2012679926A5040776712 @default.
• W2012679926 hasAuthorship W2012679926A5050893434 @default.
• W2012679926 hasAuthorship W2012679926A5051407681 @default.
• W2012679926 hasAuthorship W2012679926A5081649846 @default.
• W2012679926 hasAuthorship W2012679926A5083812045 @default.
• W2012679926 hasBestOaLocation W20126799261 @default.
• W2012679926 hasConcept C137061746 @default.
• W2012679926 hasConcept C142724271 @default.
• W2012679926 hasConcept C1491633281 @default.
• W2012679926 hasConcept C154317977 @default.
• W2012679926 hasConcept C185592680 @default.
• W2012679926 hasConcept C202751555 @default.
• W2012679926 hasConcept C203014093 @default.
• W2012679926 hasConcept C2777911650 @default.
• W2012679926 hasConcept C2778227246 @default.
• W2012679926 hasConcept C2779130545 @default.
• W2012679926 hasConcept C2909873072 @default.
• W2012679926 hasConcept C502942594 @default.
• W2012679926 hasConcept C523546767 @default.
• W2012679926 hasConcept C54355233 @default.
• W2012679926 hasConcept C55493867 @default.
• W2012679926 hasConcept C71924100 @default.
• W2012679926 hasConcept C86803240 @default.
• W2012679926 hasConcept C98274493 @default.
• W2012679926 hasConceptScore W2012679926C137061746 @default.
• W2012679926 hasConceptScore W2012679926C142724271 @default.
• W2012679926 hasConceptScore W2012679926C1491633281 @default.
• W2012679926 hasConceptScore W2012679926C154317977 @default.
• W2012679926 hasConceptScore W2012679926C185592680 @default.
• W2012679926 hasConceptScore W2012679926C202751555 @default.
• W2012679926 hasConceptScore W2012679926C203014093 @default.
• W2012679926 hasConceptScore W2012679926C2777911650 @default.
• W2012679926 hasConceptScore W2012679926C2778227246 @default.
• W2012679926 hasConceptScore W2012679926C2779130545 @default.
• W2012679926 hasConceptScore W2012679926C2909873072 @default.
• W2012679926 hasConceptScore W2012679926C502942594 @default.
• W2012679926 hasConceptScore W2012679926C523546767 @default.
• W2012679926 hasConceptScore W2012679926C54355233 @default.
• W2012679926 hasConceptScore W2012679926C55493867 @default.
• W2012679926 hasConceptScore W2012679926C71924100 @default.
• W2012679926 hasConceptScore W2012679926C86803240 @default.
• W2012679926 hasConceptScore W2012679926C98274493 @default.
• W2012679926 hasLocation W20126799261 @default.
• W2012679926 hasOpenAccess W2012679926 @default.
• W2012679926 hasPrimaryLocation W20126799261 @default.
• W2012679926 hasRelatedWork W130007681 @default.
• W2012679926 hasRelatedWork W1963500287 @default.
• W2012679926 hasRelatedWork W1986109840 @default.
• W2012679926 hasRelatedWork W1994936881 @default.
• W2012679926 hasRelatedWork W2054206233 @default.
• W2012679926 hasRelatedWork W2090761313 @default.
• W2012679926 hasRelatedWork W2099162892 @default.
• W2012679926 hasRelatedWork W2150976978 @default.
• W2012679926 hasRelatedWork W2169678144 @default.
• W2012679926 hasRelatedWork W2324718563 @default.
• W2012679926 hasRelatedWork W2395377164 @default.
• W2012679926 hasRelatedWork W2398967003 @default.
• W2012679926 hasRelatedWork W2399683259 @default.
• W2012679926 hasRelatedWork W2402168122 @default.

• next