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- W2012685405 abstract "Prostaglandins, particularly PGE2, are important to adult bone and joint health, but how prostaglandins act on growth plate cartilage to affect bone growth is unclear. We show that growth plate cartilage is distinct from articular cartilage with respect to cyclooxygenase (COX)-2 mRNA expression; although articular chondrocytes express very little COX-2, COX-2 expression is high in growth plate chondrocytes and is increased by IGF-I. In bovine primary growth plate chondrocytes, ATDC5 cells, and human metatarsal explants, inhibition of COX activity with nonsteroidal antiinflammatory drugs (NSAIDs) inhibits chondrocyte proliferation and ERK activation by IGF-I. This inhibition is reversed by prostaglandin E2 and prostacyclin (PGI2) but not by prostaglandin D2 or thromboxane B2. Inhibition of COX activity in young mice by ip injections of NSAIDs causes dwarfism. In growth plate chondrocytes, inhibition of proliferation and ERK activation by NSAIDs is reversed by forskolin, 8-bromoadenosine, 3′,5′-cAMP and a prostacyclin analog, iloprost. The inhibition of proliferation and ERK activation by celecoxib is also reversed by 8CPT-2Me-cAMP, an activator of Epac, implicating the small G protein Rap1 in the pathway activated by iloprost. These results imply that prostacyclin is required for proper growth plate development and bone growth." @default.
- W2012685405 created "2016-06-24" @default.
- W2012685405 creator A5033634039 @default.
- W2012685405 creator A5043559854 @default.
- W2012685405 date "2014-11-18" @default.
- W2012685405 modified "2023-09-27" @default.
- W2012685405 title "Prostacyclin Regulates Bone Growth via the Epac/Rap1 Pathway" @default.
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- W2012685405 cites W1851415304 @default.
- W2012685405 cites W1972032256 @default.
- W2012685405 cites W1974280648 @default.
- W2012685405 cites W1976849281 @default.
- W2012685405 cites W1977074371 @default.
- W2012685405 cites W1978022198 @default.
- W2012685405 cites W1982460743 @default.
- W2012685405 cites W1984817398 @default.
- W2012685405 cites W1985844039 @default.
- W2012685405 cites W1985901055 @default.
- W2012685405 cites W1986373312 @default.
- W2012685405 cites W1988999184 @default.
- W2012685405 cites W1993876642 @default.
- W2012685405 cites W2003903834 @default.
- W2012685405 cites W2005065234 @default.
- W2012685405 cites W2007454226 @default.
- W2012685405 cites W2019515861 @default.
- W2012685405 cites W2020563114 @default.
- W2012685405 cites W2021579922 @default.
- W2012685405 cites W2023221948 @default.
- W2012685405 cites W2026109741 @default.
- W2012685405 cites W2026443335 @default.
- W2012685405 cites W2033498682 @default.
- W2012685405 cites W2040040765 @default.
- W2012685405 cites W2043525438 @default.
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- W2012685405 cites W2047057752 @default.
- W2012685405 cites W2053242629 @default.
- W2012685405 cites W2054925689 @default.
- W2012685405 cites W2055128478 @default.
- W2012685405 cites W2056652223 @default.
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- W2012685405 cites W2075194293 @default.
- W2012685405 cites W2076007255 @default.
- W2012685405 cites W2076326230 @default.
- W2012685405 cites W2076841267 @default.
- W2012685405 cites W2078817264 @default.
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- W2012685405 cites W2139898754 @default.
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- W2012685405 cites W2149753558 @default.
- W2012685405 cites W2157776145 @default.
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- W2012685405 doi "https://doi.org/10.1210/en.2014-1348" @default.
- W2012685405 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4298325" @default.
- W2012685405 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25406016" @default.
- W2012685405 hasPublicationYear "2014" @default.
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