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- W2012687605 abstract "More than half of the patients with high-risk neuroblastoma (NB) will relapse despite intensive multimodal therapy, with an additional 10% to 20% refractory to induction chemotherapy. Management of these patients is challenging, given disease heterogeneity, resistance, and organ toxicity including poor hematological reserve. This review will discuss the current treatment options and consider novel therapies on the horizon. Cytotoxic chemotherapy regimens for relapse and refractory NB typically center on the use of the camptothecins, topotecan and irinotecan, in combination with agents such as cyclophosphamide and temozolomide, with objective responses but poor long-term survival. I-meta-iodobenzylguanidine therapy is also effective for relapsed patients with meta-iodobenzylguanidine-avid disease, with objective responses in a third of cases. Immunotherapy with anti-GD2 has recently been incorporated into upfront therapy, but its role in the relapse setting remains uncertain, especially for patients with bulky disease. Future cell-based immunotherapies and other approaches may be able to overcome this limitation. Finally, many novel molecularly targeted agents are in development, some of which show specific promise for NB. Successful incorporation of these agents will require combinations with conventional cytotoxic chemotherapies, as well as the development of predictive biomarkers, to ultimately personalize approaches to patients with targetable molecular abnormalities." @default.
- W2012687605 created "2016-06-24" @default.
- W2012687605 creator A5028980058 @default.
- W2012687605 creator A5038794162 @default.
- W2012687605 creator A5039311333 @default.
- W2012687605 date "2013-07-01" @default.
- W2012687605 modified "2023-09-25" @default.
- W2012687605 title "Current and Future Strategies for Relapsed Neuroblastoma" @default.
- W2012687605 cites W1574327664 @default.
- W2012687605 cites W1894683927 @default.
- W2012687605 cites W1901103115 @default.
- W2012687605 cites W1935226228 @default.
- W2012687605 cites W1965773171 @default.
- W2012687605 cites W1966020001 @default.
- W2012687605 cites W1967988534 @default.
- W2012687605 cites W1968656375 @default.
- W2012687605 cites W1969951398 @default.
- W2012687605 cites W1971291234 @default.
- W2012687605 cites W1971536761 @default.
- W2012687605 cites W1976833570 @default.
- W2012687605 cites W1981914165 @default.
- W2012687605 cites W1985200617 @default.
- W2012687605 cites W1985592152 @default.
- W2012687605 cites W1986399662 @default.
- W2012687605 cites W1990021507 @default.
- W2012687605 cites W1992890836 @default.
- W2012687605 cites W1995125767 @default.
- W2012687605 cites W1999180631 @default.
- W2012687605 cites W2001477876 @default.
- W2012687605 cites W2004919491 @default.
- W2012687605 cites W2005572199 @default.
- W2012687605 cites W2006047932 @default.
- W2012687605 cites W2007680507 @default.
- W2012687605 cites W2010978319 @default.
- W2012687605 cites W2011909208 @default.
- W2012687605 cites W2012584613 @default.
- W2012687605 cites W2012797500 @default.
- W2012687605 cites W2014505054 @default.
- W2012687605 cites W2015214465 @default.
- W2012687605 cites W2020122374 @default.
- W2012687605 cites W2020980833 @default.
- W2012687605 cites W2021673773 @default.
- W2012687605 cites W2022142157 @default.
- W2012687605 cites W2022354436 @default.
- W2012687605 cites W2032775628 @default.
- W2012687605 cites W2033485414 @default.
- W2012687605 cites W2035282066 @default.
- W2012687605 cites W2040967153 @default.
- W2012687605 cites W2046209641 @default.
- W2012687605 cites W2048361108 @default.
- W2012687605 cites W2054329419 @default.
- W2012687605 cites W2054524692 @default.
- W2012687605 cites W2055201556 @default.
- W2012687605 cites W2056956487 @default.
- W2012687605 cites W2057738343 @default.
- W2012687605 cites W2057975969 @default.
- W2012687605 cites W2060275730 @default.
- W2012687605 cites W2064013031 @default.
- W2012687605 cites W2064510700 @default.
- W2012687605 cites W2064907862 @default.
- W2012687605 cites W2065738922 @default.
- W2012687605 cites W2068167166 @default.
- W2012687605 cites W2068890283 @default.
- W2012687605 cites W2069356699 @default.
- W2012687605 cites W2070301701 @default.
- W2012687605 cites W2072328760 @default.
- W2012687605 cites W2077014658 @default.
- W2012687605 cites W2078313893 @default.
- W2012687605 cites W2081385675 @default.
- W2012687605 cites W2086219681 @default.
- W2012687605 cites W2087055812 @default.
- W2012687605 cites W2091158789 @default.
- W2012687605 cites W2094517517 @default.
- W2012687605 cites W2095822339 @default.
- W2012687605 cites W2096398040 @default.
- W2012687605 cites W2096506747 @default.
- W2012687605 cites W2098147098 @default.
- W2012687605 cites W2098908781 @default.
- W2012687605 cites W2100919400 @default.
- W2012687605 cites W2102118318 @default.
- W2012687605 cites W2103558670 @default.
- W2012687605 cites W2107504931 @default.
- W2012687605 cites W2108541596 @default.
- W2012687605 cites W2109378990 @default.
- W2012687605 cites W2110788947 @default.
- W2012687605 cites W2114441352 @default.
- W2012687605 cites W2118023637 @default.
- W2012687605 cites W2118171008 @default.
- W2012687605 cites W2121146521 @default.
- W2012687605 cites W2124064787 @default.
- W2012687605 cites W2124358755 @default.
- W2012687605 cites W2124891389 @default.
- W2012687605 cites W2126358767 @default.
- W2012687605 cites W2127478952 @default.
- W2012687605 cites W2127775057 @default.
- W2012687605 cites W2128774674 @default.
- W2012687605 cites W2130465135 @default.
- W2012687605 cites W2130926603 @default.