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- W2012690167 abstract "Coenzymes Q10, Q6 and hexahydrocoenzyme Q4 are able to stimulate the phagocytic rate of rats. The optimal time of activity appears 4 h after administration in the case of hexahydrocoenzyme Q4 while coenzymes Q6 and Q10 have similar times of optimal activity, between 24–48 h after administration. Coenzyme Q10 produces a more pronounced stimulation than either coenzyme Q6 or hexahydrocoenzyme Q4. Coenzyme Q0, eicosahydrocoenzyme Q10, and the 6-chromenols derived from coenzyme Q6 and coenzyme Q10 are unable to stimulate the phagocytic rate of rats at the doses and administration time tested. Vitamin E also proved ineffective under the conditions studied. Vitamins K1 and K3 were able to stimulate the phagocytic rate of rats at doses much higher than those that proved effective with the coenzymes Q. However, since these vitamins are known to be involved in prothrombinogenic processes, the mechanism by which they are able to elicit phagocytic stimulation in rats might not be the same as that operative in the coenzymes Q case. It appears that there is a structural requirement in the coenzyme Q family for stimulation of phagocytosis in rats for a quinoidal moiety with an at least partially unsaturated side chain." @default.
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- W2012690167 date "1972-06-01" @default.
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- W2012690167 title "Effect and structure-activity relationship of the coenzymes Q on the phagocytic rate of rats" @default.
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- W2012690167 doi "https://doi.org/10.1016/0009-2797(72)90042-7" @default.
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