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- W2012718822 abstract "Abstract The amyloid-β peptide (Aβ) is widely considered to be the major toxic agent in the pathogenesis of Alzheimer’s disease, a condition which afflicts approximately 36 million people worldwide. Despite a plethora of studies stretching back over two decades, identifying the toxic Aβ species has proved difficult. Debate has centred on the Aβ fibril and oligomer. Despite support from numerous experimental models, important questions linger regarding the role of the Aβ oligomer in particular. It is likely a huge array of oligomers, rather than a single species, which cause toxicity. Reappraisal of the role of the Aβ fibril points towards a dynamic relationship with the Aβ oligomer within an integrated system, as supported by evidence from microglia. However, some continue to doubt the pathological role of amyloid β, instead proposing a protective role. If the field is to progress, all Aβ oligomers should be characterised, the nomenclature revised and a consistent experimental protocol defined. For this to occur, collaboration will be required between major research groups and innovative analytical tools developed. Such action must surely be taken if amyloid-based therapeutic endeavour is to progress." @default.
- W2012718822 created "2016-06-24" @default.
- W2012718822 creator A5050200614 @default.
- W2012718822 date "2014-01-21" @default.
- W2012718822 modified "2023-10-17" @default.
- W2012718822 title "Republished: The role of amyloid β in the pathogenesis of Alzheimer’s disease" @default.
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- W2012718822 doi "https://doi.org/10.1136/postgradmedj-2013-201515rep" @default.
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