Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012722411> ?p ?o ?g. }
Showing items 1 to 58 of
58
with 100 items per page.
- W2012722411 abstract "Trimazosin is a quinazoline antihypertensive agent structurally related to the selective alpha 1-adrenoceptor blocker prazosin. Trimazosin has been shown previously to have less affinity for alpha 1-adrenoceptors than prazosin. In the present study we compared the hypotensive potency and efficacy of the two agents, and their effects on pressor responses to phenylephrine in anesthetized dogs. We also determined the effect of trimazosin administered during a maximum hypotensive response to prazosin, and of sodium nitroprusside administered after trimazosin or prazosin. Compared with prazosin, trimazosin was a less potent but more efficacious hypotensive agent. At doses which caused equal or even greater hypotensive effects than those caused by prazosin, trimazosin caused less inhibition of pressor responses to phenylephrine. When administered during a maximum hypotensive response to prazosin, trimazosin caused an additional fall in pressure. These results clearly demonstrate an additional action of trimazosin beyond blockade of alpha 1-adrenoceptors. Both trimazosin and prazosin augmented the hypotensive effect of sodium nitroprusside, but only trimazosin enhanced its relaxant effect on isolated rat aorta. Thus we conclude that in addition to alpha 1-adrenoceptor blockade, another mechanism contributes to the hypotensive effect of trimazosin, and we speculate that elevation of cyclic GMP levels in vascular smooth muscle may be related to this additional mechanism." @default.
- W2012722411 created "2016-06-24" @default.
- W2012722411 creator A5025406092 @default.
- W2012722411 creator A5051178675 @default.
- W2012722411 creator A5087680944 @default.
- W2012722411 date "1984-01-01" @default.
- W2012722411 modified "2023-09-27" @default.
- W2012722411 title "The Hypotensive Effect of Trimazosin Is Not Caused Solely by ??1-Adrenoceptor Blockade" @default.
- W2012722411 doi "https://doi.org/10.1097/00005344-198401000-00022" @default.
- W2012722411 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6199597" @default.
- W2012722411 hasPublicationYear "1984" @default.
- W2012722411 type Work @default.
- W2012722411 sameAs 2012722411 @default.
- W2012722411 citedByCount "9" @default.
- W2012722411 crossrefType "journal-article" @default.
- W2012722411 hasAuthorship W2012722411A5025406092 @default.
- W2012722411 hasAuthorship W2012722411A5051178675 @default.
- W2012722411 hasAuthorship W2012722411A5087680944 @default.
- W2012722411 hasConcept C126322002 @default.
- W2012722411 hasConcept C170493617 @default.
- W2012722411 hasConcept C2776885963 @default.
- W2012722411 hasConcept C2777952589 @default.
- W2012722411 hasConcept C2778468042 @default.
- W2012722411 hasConcept C2779610285 @default.
- W2012722411 hasConcept C2780648677 @default.
- W2012722411 hasConcept C519581460 @default.
- W2012722411 hasConcept C71924100 @default.
- W2012722411 hasConcept C84393581 @default.
- W2012722411 hasConcept C98274493 @default.
- W2012722411 hasConceptScore W2012722411C126322002 @default.
- W2012722411 hasConceptScore W2012722411C170493617 @default.
- W2012722411 hasConceptScore W2012722411C2776885963 @default.
- W2012722411 hasConceptScore W2012722411C2777952589 @default.
- W2012722411 hasConceptScore W2012722411C2778468042 @default.
- W2012722411 hasConceptScore W2012722411C2779610285 @default.
- W2012722411 hasConceptScore W2012722411C2780648677 @default.
- W2012722411 hasConceptScore W2012722411C519581460 @default.
- W2012722411 hasConceptScore W2012722411C71924100 @default.
- W2012722411 hasConceptScore W2012722411C84393581 @default.
- W2012722411 hasConceptScore W2012722411C98274493 @default.
- W2012722411 hasLocation W20127224111 @default.
- W2012722411 hasLocation W20127224112 @default.
- W2012722411 hasOpenAccess W2012722411 @default.
- W2012722411 hasPrimaryLocation W20127224111 @default.
- W2012722411 hasRelatedWork W1969484379 @default.
- W2012722411 hasRelatedWork W2010332437 @default.
- W2012722411 hasRelatedWork W2023307846 @default.
- W2012722411 hasRelatedWork W2051091528 @default.
- W2012722411 hasRelatedWork W2086715796 @default.
- W2012722411 hasRelatedWork W2086746683 @default.
- W2012722411 hasRelatedWork W2125281493 @default.
- W2012722411 hasRelatedWork W2129759033 @default.
- W2012722411 hasRelatedWork W2404186823 @default.
- W2012722411 hasRelatedWork W4232618451 @default.
- W2012722411 isParatext "false" @default.
- W2012722411 isRetracted "false" @default.
- W2012722411 magId "2012722411" @default.
- W2012722411 workType "article" @default.