FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012726717> ?p ?o ?g. }

• W2012726717 endingPage "2962" @default.
• W2012726717 startingPage "2957" @default.
• W2012726717 abstract "Hypoxia-inducible factor-1α (HIF-1α) and differentiated embryo-chondrocyte expressed gene 1 (DEC1) are two key factors that protect hepatocellular carcinoma (HCC) cells from a hypoxic microenvironment. However, little is known concerning the effects of hypoxia on the expression of HIF-1α and DEC1 in HCC. In the present study, RT-PCR and western blotting were conducted to assay the mRNA and protein levels of HIF-1α and DEC1 under normoxia and hypoxia induced by exposure to CoCl2 for different time periods (0, 2, 4, 6, 24 and 48 h). In addition, the HIF-1α protein inhibitor, YC-1, was used to analyze the interaction between DEC1 and HIF-1α expression and the related mechanism. Results showed that expression of DEC1 in HCC was significantly upregulated at both the mRNA and protein levels, when compared with that in normal liver cells (P 0.05). A positive correlation was found between HIF-1α and DEC1 expression in both BEL-7402 (r=0.885, P<0.05) and SMMC-7721 cells (r=0.826, P<0.05). Furthermore, inhibition of HIF-1α by YC-1 led to a significant decrease in DEC1 induced by hypoxia (P<0.05). We suggest that hypoxia induced the overexpression of DEC1, the mechanism of which may be related to the upregulation of HIF-1α in HCC. The efficacy of inhibiting HIF-1α and DEC1 expression as a possible treatment for HCC should be assessed in clinical trials." @default.
• W2012726717 created "2016-06-24" @default.
• W2012726717 creator A5000102044 @default.
• W2012726717 creator A5002389534 @default.
• W2012726717 creator A5006847122 @default.
• W2012726717 creator A5033581206 @default.
• W2012726717 creator A5067092208 @default.
• W2012726717 date "2013-10-01" @default.
• W2012726717 modified "2023-10-12" @default.
• W2012726717 title "Hypoxia-induced overexpression of DEC1 is regulated by HIF-1α in hepatocellular carcinoma" @default.
• W2012726717 cites W1966456305 @default.
• W2012726717 cites W1967972966 @default.
• W2012726717 cites W1979143271 @default.
• W2012726717 cites W1979831342 @default.
• W2012726717 cites W1983189984 @default.
• W2012726717 cites W1994527304 @default.
• W2012726717 cites W1996310543 @default.
• W2012726717 cites W2000012280 @default.
• W2012726717 cites W2011615798 @default.
• W2012726717 cites W2023279237 @default.
• W2012726717 cites W2057212896 @default.
• W2012726717 cites W2075304914 @default.
• W2012726717 cites W2080831931 @default.
• W2012726717 cites W2090395289 @default.
• W2012726717 cites W2090786698 @default.
• W2012726717 cites W2103533619 @default.
• W2012726717 cites W2106865419 @default.
• W2012726717 cites W2117649842 @default.
• W2012726717 cites W2137713209 @default.
• W2012726717 cites W2144381037 @default.
• W2012726717 cites W2151762874 @default.
• W2012726717 cites W2166381187 @default.
• W2012726717 cites W2168014041 @default.
• W2012726717 doi "https://doi.org/10.3892/or.2013.2774" @default.
• W2012726717 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24100543" @default.
• W2012726717 hasPublicationYear "2013" @default.
• W2012726717 type Work @default.
• W2012726717 sameAs 2012726717 @default.
• W2012726717 citedByCount "19" @default.
• W2012726717 countsByYear W20127267172014 @default.
• W2012726717 countsByYear W20127267172016 @default.
• W2012726717 countsByYear W20127267172017 @default.
• W2012726717 countsByYear W20127267172018 @default.
• W2012726717 countsByYear W20127267172019 @default.
• W2012726717 countsByYear W20127267172020 @default.
• W2012726717 countsByYear W20127267172021 @default.
• W2012726717 countsByYear W20127267172022 @default.
• W2012726717 countsByYear W20127267172023 @default.
• W2012726717 crossrefType "journal-article" @default.
• W2012726717 hasAuthorship W2012726717A5000102044 @default.
• W2012726717 hasAuthorship W2012726717A5002389534 @default.
• W2012726717 hasAuthorship W2012726717A5006847122 @default.
• W2012726717 hasAuthorship W2012726717A5033581206 @default.
• W2012726717 hasAuthorship W2012726717A5067092208 @default.
• W2012726717 hasBestOaLocation W20127267171 @default.
• W2012726717 hasConcept C126322002 @default.
• W2012726717 hasConcept C178790620 @default.
• W2012726717 hasConcept C185592680 @default.
• W2012726717 hasConcept C190283241 @default.
• W2012726717 hasConcept C2778019345 @default.
• W2012726717 hasConcept C2781018059 @default.
• W2012726717 hasConcept C29537977 @default.
• W2012726717 hasConcept C502942594 @default.
• W2012726717 hasConcept C540031477 @default.
• W2012726717 hasConcept C54355233 @default.
• W2012726717 hasConcept C67082663 @default.
• W2012726717 hasConcept C71924100 @default.
• W2012726717 hasConcept C7836513 @default.
• W2012726717 hasConcept C86803240 @default.
• W2012726717 hasConceptScore W2012726717C126322002 @default.
• W2012726717 hasConceptScore W2012726717C178790620 @default.
• W2012726717 hasConceptScore W2012726717C185592680 @default.
• W2012726717 hasConceptScore W2012726717C190283241 @default.
• W2012726717 hasConceptScore W2012726717C2778019345 @default.
• W2012726717 hasConceptScore W2012726717C2781018059 @default.
• W2012726717 hasConceptScore W2012726717C29537977 @default.
• W2012726717 hasConceptScore W2012726717C502942594 @default.
• W2012726717 hasConceptScore W2012726717C540031477 @default.
• W2012726717 hasConceptScore W2012726717C54355233 @default.
• W2012726717 hasConceptScore W2012726717C67082663 @default.
• W2012726717 hasConceptScore W2012726717C71924100 @default.
• W2012726717 hasConceptScore W2012726717C7836513 @default.
• W2012726717 hasConceptScore W2012726717C86803240 @default.
• W2012726717 hasIssue "6" @default.
• W2012726717 hasLocation W20127267171 @default.
• W2012726717 hasOpenAccess W2012726717 @default.
• W2012726717 hasPrimaryLocation W20127267171 @default.
• W2012726717 hasRelatedWork W2005837469 @default.
• W2012726717 hasRelatedWork W2048146059 @default.
• W2012726717 hasRelatedWork W2064378035 @default.
• W2012726717 hasRelatedWork W2765243847 @default.
• W2012726717 hasRelatedWork W2916291492 @default.
• W2012726717 hasRelatedWork W2995623212 @default.
• W2012726717 hasRelatedWork W3011706734 @default.
• W2012726717 hasRelatedWork W3039901074 @default.
• W2012726717 hasRelatedWork W3045868324 @default.
• W2012726717 hasRelatedWork W3112880321 @default.
• W2012726717 hasVolume "30" @default.

• next