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- W2012730005 abstract "In previous studies, we identified two major Comamonas testosteroni TA441 gene clusters involved in steroid degradation. Because most of the genes included in these clusters were revealed to be involved in degradation of basic steroidal structures and a few were suggested to be involved in the degradation of modified steroid compounds, we investigated the spectrum of steroid compounds degradable for TA441 to better identify the genes involved in steroid degradation. TA441 degraded testosterone, progesterone, epiandrosterone, dehydroepiandrosterone, cholic acid, deoxycholic acid, chenodeoxycholic acid, and lithocholic acid. The results suggested TA441 having 3α-dehydrogenase and Δ4(5)-isomerase, and 3β-,17β-dehydrogenase gene, we isolated these genes, all of which had high homology to the corresponding genes of C. testosteroni ATCC11996. Results of gene-disruption experiments indicated that 3β,17β-dehydrogenase is a unique 3β-dehydrogenase which also acts as a 17β-dehydrogenase in TA441, and there will be at least one more enzyme with 17β-dehydrogenating activity. The 3α-dehydrogenase and Δ4(5)-isomerase genes were found adjacent in the DNA region between the two main steroid degradation gene clusters together with a number of other genes that may be involved in steroid degradation, suggesting the presence of a steroid degradation gene hot spot over 100 kb in size in TA441." @default.
- W2012730005 created "2016-06-24" @default.
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- W2012730005 date "2010-10-01" @default.
- W2012730005 modified "2023-10-17" @default.
- W2012730005 title "Steroid degradation genes in Comamonas testosteroni TA441: Isolation of genes encoding a Δ4(5)-isomerase and 3α- and 3β-dehydrogenases and evidence for a 100kb steroid degradation gene hot spot" @default.
- W2012730005 cites W1484252392 @default.
- W2012730005 cites W1537148694 @default.
- W2012730005 cites W1577233933 @default.
- W2012730005 cites W1593141875 @default.
- W2012730005 cites W1599367494 @default.
- W2012730005 cites W1601728385 @default.
- W2012730005 cites W1607294005 @default.
- W2012730005 cites W1621884619 @default.
- W2012730005 cites W1845918780 @default.
- W2012730005 cites W1966971069 @default.
- W2012730005 cites W1967074747 @default.
- W2012730005 cites W1969381574 @default.
- W2012730005 cites W1973384539 @default.
- W2012730005 cites W1975344249 @default.
- W2012730005 cites W1978137736 @default.
- W2012730005 cites W1980730280 @default.
- W2012730005 cites W1984209597 @default.
- W2012730005 cites W1989292408 @default.
- W2012730005 cites W1991718871 @default.
- W2012730005 cites W1992612522 @default.
- W2012730005 cites W1994527258 @default.
- W2012730005 cites W1994613310 @default.
- W2012730005 cites W2001289686 @default.
- W2012730005 cites W2006094944 @default.
- W2012730005 cites W2009549514 @default.
- W2012730005 cites W2010194266 @default.
- W2012730005 cites W2011024137 @default.
- W2012730005 cites W2014075317 @default.
- W2012730005 cites W2016311202 @default.
- W2012730005 cites W2020767172 @default.
- W2012730005 cites W2021637694 @default.
- W2012730005 cites W2025232791 @default.
- W2012730005 cites W2026850376 @default.
- W2012730005 cites W2034353029 @default.
- W2012730005 cites W2036328812 @default.
- W2012730005 cites W2045200382 @default.
- W2012730005 cites W2047162568 @default.
- W2012730005 cites W2059457208 @default.
- W2012730005 cites W2059920857 @default.
- W2012730005 cites W2063016542 @default.
- W2012730005 cites W2063623081 @default.
- W2012730005 cites W2065224272 @default.
- W2012730005 cites W2067681959 @default.
- W2012730005 cites W2069888313 @default.
- W2012730005 cites W2070216074 @default.
- W2012730005 cites W2074739152 @default.
- W2012730005 cites W2081545665 @default.
- W2012730005 cites W2085684960 @default.
- W2012730005 cites W2093363647 @default.
- W2012730005 cites W2094891485 @default.
- W2012730005 cites W2095826321 @default.
- W2012730005 cites W2097047668 @default.
- W2012730005 cites W2097745589 @default.
- W2012730005 cites W2100950639 @default.
- W2012730005 cites W2102173385 @default.
- W2012730005 cites W2114253732 @default.
- W2012730005 cites W2116629820 @default.
- W2012730005 cites W2142320009 @default.
- W2012730005 cites W2146718734 @default.
- W2012730005 cites W2155534524 @default.
- W2012730005 cites W2160911033 @default.
- W2012730005 cites W2165037150 @default.
- W2012730005 cites W2171617274 @default.
- W2012730005 cites W2204733082 @default.
- W2012730005 cites W2222226855 @default.
- W2012730005 cites W2240247789 @default.
- W2012730005 cites W2321744691 @default.
- W2012730005 cites W2324515062 @default.
- W2012730005 cites W2333976211 @default.
- W2012730005 cites W2412739524 @default.
- W2012730005 cites W2415532368 @default.
- W2012730005 cites W2527071685 @default.
- W2012730005 cites W4246573826 @default.
- W2012730005 cites W4251794398 @default.
- W2012730005 doi "https://doi.org/10.1016/j.jsbmb.2010.06.002" @default.
- W2012730005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20554032" @default.
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