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• W2012735567 abstract "Daily rhythms in respone to aversive thermal stimulation and the analgesic effectiveness of morphine were assessed by the hot-plate method with young (1–2 months), mature (8–12 months) and old (20–30 months) mice exposed to various light-dark conditions (LD 12:12; 16:8; 8:16 h). The patterns of response after saline or morphine varied with the specific light-dark conditions examined, but routinely, there were increases in response latency from the early portions of the light phase to later time, and a further enhancement of the time to respond with onset of the dark phase. The dark-phase response declined abruptly with the start of the light-phase. Significant age-related declines were observed in the elevated, dark-phase morphine-analgesic and basal aversive responses, with no consistent effects of age evident in the light-phase." @default.
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• W2012735567 date "1983-11-01" @default.
• W2012735567 modified "2023-09-26" @default.
• W2012735567 title "Daily rhythms of analgesia in mice: effects of age and photoperiod" @default.
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• W2012735567 doi "https://doi.org/10.1016/0006-8993(83)90216-0" @default.
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