Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012739235> ?p ?o ?g. }
- W2012739235 endingPage "425" @default.
- W2012739235 startingPage "421" @default.
- W2012739235 abstract "Hepatitis C virus (HCV) is the main cause of chronic liver disease, cirrhosis and hepatocellular carcinoma (HCC) worldwide. The risk for the development of HCC increases with the severity of liver inflammation and fibrosis. The hepatic inflammation caused by HCV involves host regulatory immune response, which is mediated by cytokines with anti-viral role upon the interaction of viral polypeptides with innate and adaptive immunity. Two cytokines; tumor necrosis factor-α (TNF-α) and interleukin-10 (IL-10) play key roles in the regulation of cellular immune response in HCV infection. The aim of the present study was to determine the levels of IL-10 and TNF-α, as well as the ratio of TNF-α and IL-10 serum levels in patients with HCV and HCC caused by HCV (HCC-HCV). The study included 173 patients with chronic HCV. TNF-α and IL-10 serum levels were measured by ELISA (R&D Systems, Inc.). In the present study, 54 patients presented liver mild fibrosis, 68 had severe fibrosis and 51 patients had HCC. After adjustment in the multivariate regression analysis, the following variables remained significantly associated with HCC-HCV occurrence: diabetes (p=0.012 OR 10.44 CI 1.66-65.60), IL-10 lower levels (p<0.0001 OR 0.83 CI 0.78-0.89) and TNF-α higher levels (p<0.0001 OR 1.19 CI 1.11-1.28). Individuals with HCC presented higher TNF-α/IL-10 ratio than those with fibrosis grade F4, F3 or F0+F1+F2 (p=0.0003, p<0.0001, p<0.0001, respectively). Patients with HCC were associated to higher index TNF-α/IL-10 ratio, suggesting that the unbalanced production of these cytokines may represent progression to the liver disease severity in HCV infected patients." @default.
- W2012739235 created "2016-06-24" @default.
- W2012739235 creator A5002329191 @default.
- W2012739235 creator A5008087761 @default.
- W2012739235 creator A5013153989 @default.
- W2012739235 creator A5020179339 @default.
- W2012739235 creator A5034789688 @default.
- W2012739235 creator A5036366863 @default.
- W2012739235 creator A5048158848 @default.
- W2012739235 creator A5062293078 @default.
- W2012739235 creator A5062602270 @default.
- W2012739235 creator A5064005168 @default.
- W2012739235 creator A5071532782 @default.
- W2012739235 creator A5071692473 @default.
- W2012739235 date "2013-06-01" @default.
- W2012739235 modified "2023-10-17" @default.
- W2012739235 title "High tumor necrosis factor-α/interleukin-10 ratio is associated with hepatocellular carcinoma in patients with chronic hepatitis C" @default.
- W2012739235 cites W1519438828 @default.
- W2012739235 cites W1963564133 @default.
- W2012739235 cites W1965037168 @default.
- W2012739235 cites W1965210321 @default.
- W2012739235 cites W1982713643 @default.
- W2012739235 cites W1986986419 @default.
- W2012739235 cites W1987772231 @default.
- W2012739235 cites W1992041839 @default.
- W2012739235 cites W1996743123 @default.
- W2012739235 cites W1997743635 @default.
- W2012739235 cites W2007119568 @default.
- W2012739235 cites W2015361679 @default.
- W2012739235 cites W2015879043 @default.
- W2012739235 cites W2024395503 @default.
- W2012739235 cites W2029858008 @default.
- W2012739235 cites W2043835301 @default.
- W2012739235 cites W2050545442 @default.
- W2012739235 cites W2053526872 @default.
- W2012739235 cites W2057529515 @default.
- W2012739235 cites W2062607785 @default.
- W2012739235 cites W2071267501 @default.
- W2012739235 cites W2079486877 @default.
- W2012739235 cites W2090682255 @default.
- W2012739235 cites W2094174828 @default.
- W2012739235 cites W2097211832 @default.
- W2012739235 cites W2132116288 @default.
- W2012739235 cites W2133263279 @default.
- W2012739235 cites W2135174931 @default.
- W2012739235 cites W2161074777 @default.
- W2012739235 cites W2163403599 @default.
- W2012739235 cites W2169385554 @default.
- W2012739235 cites W2171459379 @default.
- W2012739235 cites W4243625103 @default.
- W2012739235 cites W4255712601 @default.
- W2012739235 doi "https://doi.org/10.1016/j.cyto.2013.03.024" @default.
- W2012739235 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23602201" @default.
- W2012739235 hasPublicationYear "2013" @default.
- W2012739235 type Work @default.
- W2012739235 sameAs 2012739235 @default.
- W2012739235 citedByCount "42" @default.
- W2012739235 countsByYear W20127392352013 @default.
- W2012739235 countsByYear W20127392352015 @default.
- W2012739235 countsByYear W20127392352016 @default.
- W2012739235 countsByYear W20127392352017 @default.
- W2012739235 countsByYear W20127392352018 @default.
- W2012739235 countsByYear W20127392352019 @default.
- W2012739235 countsByYear W20127392352020 @default.
- W2012739235 countsByYear W20127392352021 @default.
- W2012739235 countsByYear W20127392352022 @default.
- W2012739235 countsByYear W20127392352023 @default.
- W2012739235 crossrefType "journal-article" @default.
- W2012739235 hasAuthorship W2012739235A5002329191 @default.
- W2012739235 hasAuthorship W2012739235A5008087761 @default.
- W2012739235 hasAuthorship W2012739235A5013153989 @default.
- W2012739235 hasAuthorship W2012739235A5020179339 @default.
- W2012739235 hasAuthorship W2012739235A5034789688 @default.
- W2012739235 hasAuthorship W2012739235A5036366863 @default.
- W2012739235 hasAuthorship W2012739235A5048158848 @default.
- W2012739235 hasAuthorship W2012739235A5062293078 @default.
- W2012739235 hasAuthorship W2012739235A5062602270 @default.
- W2012739235 hasAuthorship W2012739235A5064005168 @default.
- W2012739235 hasAuthorship W2012739235A5071532782 @default.
- W2012739235 hasAuthorship W2012739235A5071692473 @default.
- W2012739235 hasConcept C126322002 @default.
- W2012739235 hasConcept C17991360 @default.
- W2012739235 hasConcept C203014093 @default.
- W2012739235 hasConcept C2522874641 @default.
- W2012739235 hasConcept C2776408679 @default.
- W2012739235 hasConcept C2776455275 @default.
- W2012739235 hasConcept C2776914184 @default.
- W2012739235 hasConcept C2777214474 @default.
- W2012739235 hasConcept C2778019345 @default.
- W2012739235 hasConcept C2780559512 @default.
- W2012739235 hasConcept C71924100 @default.
- W2012739235 hasConcept C8891405 @default.
- W2012739235 hasConcept C90924648 @default.
- W2012739235 hasConceptScore W2012739235C126322002 @default.
- W2012739235 hasConceptScore W2012739235C17991360 @default.
- W2012739235 hasConceptScore W2012739235C203014093 @default.
- W2012739235 hasConceptScore W2012739235C2522874641 @default.
- W2012739235 hasConceptScore W2012739235C2776408679 @default.