Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012741973> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2012741973 endingPage "44" @default.
- W2012741973 startingPage "39" @default.
- W2012741973 abstract "1. Effects of nicotine on the spontaneous action potentials and the underlying ionic currents in rabbit sinoatrial (SA) nodal cells were investigated using current-clamp and whole-cell voltage-clamp modes. 2. Nicotine (30 microM to 1 mM) produced a negative chronotropic effect in a concentration-dependent manner (at 1 mM by 10.6 +/- 2.8%, n = 9, p < 0.01). Nicotine at 300 microM significantly decreased the maximum rate of depolarization by 9.8 +/- 1.3% (n = 9, p < 0.05). Other action potential parameters were not affected to any significant extent. 3. Pretreatment with atropine (1 microM) and hexamethonium (1 mM) did not modify the nicotine-induced effects. After washout, these responses were reversible. 4. Isoprenaline decreased the responses induced by nicotine, but ACh increased them. 5. Nicotine at 100 microM did not affect the L-type Ca2+ current (ICa), but at 300 microM inhibited it at + 10 mV by 21.6 +/- 2.9% (n = 6, p < 0.05). The fast time constant (tau f) of the inactivation phase for ICa was not affected, but the slow one (tau s) significantly increased from 36.8 +/- 1.9 ms to 41.2 +/- 2.8 ms (n = 6) at 300 microM nicotine. The activation and inactivation kinetics (d infinity and f infinity) for ICa were not modified. 6. Nicotine also did not affect the delayed rectifier K+ current (IK) and its activation kinetic (P infinity). 7. These results suggest that nicotine depresses the action potentials and causes a negative chronotropic effect due to inhibitions of the ionic currents in the SA nodal cells." @default.
- W2012741973 created "2016-06-24" @default.
- W2012741973 creator A5087139089 @default.
- W2012741973 date "1997-01-01" @default.
- W2012741973 modified "2023-09-26" @default.
- W2012741973 title "Effects of nicotine on spontaneous activity and underlying ionic currents in rabbit sinoatrial nodal cells" @default.
- W2012741973 cites W131849927 @default.
- W2012741973 cites W1978905101 @default.
- W2012741973 cites W1980165161 @default.
- W2012741973 cites W1980294457 @default.
- W2012741973 cites W1983128983 @default.
- W2012741973 cites W1984087760 @default.
- W2012741973 cites W1984661003 @default.
- W2012741973 cites W1987170198 @default.
- W2012741973 cites W1988323645 @default.
- W2012741973 cites W2012914146 @default.
- W2012741973 cites W2020596812 @default.
- W2012741973 cites W2025628247 @default.
- W2012741973 cites W2033255904 @default.
- W2012741973 cites W2035590645 @default.
- W2012741973 cites W2041004387 @default.
- W2012741973 cites W2042408536 @default.
- W2012741973 cites W2069450192 @default.
- W2012741973 cites W2073266439 @default.
- W2012741973 cites W2074480140 @default.
- W2012741973 cites W2087535693 @default.
- W2012741973 cites W2112320962 @default.
- W2012741973 cites W2154446983 @default.
- W2012741973 cites W2024185595 @default.
- W2012741973 doi "https://doi.org/10.1016/s0306-3623(96)00168-1" @default.
- W2012741973 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9112075" @default.
- W2012741973 hasPublicationYear "1997" @default.
- W2012741973 type Work @default.
- W2012741973 sameAs 2012741973 @default.
- W2012741973 citedByCount "14" @default.
- W2012741973 countsByYear W20127419732016 @default.
- W2012741973 countsByYear W20127419732017 @default.
- W2012741973 countsByYear W20127419732022 @default.
- W2012741973 crossrefType "journal-article" @default.
- W2012741973 hasAuthorship W2012741973A5087139089 @default.
- W2012741973 hasConcept C12554922 @default.
- W2012741973 hasConcept C126322002 @default.
- W2012741973 hasConcept C134018914 @default.
- W2012741973 hasConcept C158328960 @default.
- W2012741973 hasConcept C185592680 @default.
- W2012741973 hasConcept C24998067 @default.
- W2012741973 hasConcept C2775859210 @default.
- W2012741973 hasConcept C2775893369 @default.
- W2012741973 hasConcept C2776090920 @default.
- W2012741973 hasConcept C2777953023 @default.
- W2012741973 hasConcept C2779547902 @default.
- W2012741973 hasConcept C4141045 @default.
- W2012741973 hasConcept C71924100 @default.
- W2012741973 hasConcept C84393581 @default.
- W2012741973 hasConcept C86803240 @default.
- W2012741973 hasConceptScore W2012741973C12554922 @default.
- W2012741973 hasConceptScore W2012741973C126322002 @default.
- W2012741973 hasConceptScore W2012741973C134018914 @default.
- W2012741973 hasConceptScore W2012741973C158328960 @default.
- W2012741973 hasConceptScore W2012741973C185592680 @default.
- W2012741973 hasConceptScore W2012741973C24998067 @default.
- W2012741973 hasConceptScore W2012741973C2775859210 @default.
- W2012741973 hasConceptScore W2012741973C2775893369 @default.
- W2012741973 hasConceptScore W2012741973C2776090920 @default.
- W2012741973 hasConceptScore W2012741973C2777953023 @default.
- W2012741973 hasConceptScore W2012741973C2779547902 @default.
- W2012741973 hasConceptScore W2012741973C4141045 @default.
- W2012741973 hasConceptScore W2012741973C71924100 @default.
- W2012741973 hasConceptScore W2012741973C84393581 @default.
- W2012741973 hasConceptScore W2012741973C86803240 @default.
- W2012741973 hasIssue "1" @default.
- W2012741973 hasLocation W20127419731 @default.
- W2012741973 hasLocation W20127419732 @default.
- W2012741973 hasOpenAccess W2012741973 @default.
- W2012741973 hasPrimaryLocation W20127419731 @default.
- W2012741973 hasRelatedWork W1818290653 @default.
- W2012741973 hasRelatedWork W1960737690 @default.
- W2012741973 hasRelatedWork W1974049172 @default.
- W2012741973 hasRelatedWork W2003814569 @default.
- W2012741973 hasRelatedWork W2011006071 @default.
- W2012741973 hasRelatedWork W2016072893 @default.
- W2012741973 hasRelatedWork W2044595397 @default.
- W2012741973 hasRelatedWork W2109264166 @default.
- W2012741973 hasRelatedWork W2259609880 @default.
- W2012741973 hasRelatedWork W2344371084 @default.
- W2012741973 hasVolume "28" @default.
- W2012741973 isParatext "false" @default.
- W2012741973 isRetracted "false" @default.
- W2012741973 magId "2012741973" @default.
- W2012741973 workType "article" @default.