Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012753961> ?p ?o ?g. }
- W2012753961 endingPage "148" @default.
- W2012753961 startingPage "137" @default.
- W2012753961 abstract "The NAD-dependent histone deacetylation of Sir2 connects cellular metabolism with gene silencing as well as aging in yeast. Here, we show that mammalian Sir2α physically interacts with p53 and attenuates p53-mediated functions. Nicotinamide (Vitamin B3) inhibits an NAD-dependent p53 deacetylation induced by Sir2α, and also enhances the p53 acetylation levels in vivo. Furthermore, Sir2α represses p53-dependent apoptosis in response to DNA damage and oxidative stress, whereas expression of a Sir2α point mutant increases the sensitivity of cells in the stress response. Thus, our findings implicate a p53 regulatory pathway mediated by mammalian Sir2α. These results have significant implications regarding an important role for Sir2α in modulating the sensitivity of cells in p53-dependent apoptotic response and the possible effect in cancer therapy." @default.
- W2012753961 created "2016-06-24" @default.
- W2012753961 creator A5005092860 @default.
- W2012753961 creator A5013771208 @default.
- W2012753961 creator A5015664805 @default.
- W2012753961 creator A5020739926 @default.
- W2012753961 creator A5036476031 @default.
- W2012753961 creator A5039267744 @default.
- W2012753961 creator A5059235641 @default.
- W2012753961 creator A5081413351 @default.
- W2012753961 date "2001-10-01" @default.
- W2012753961 modified "2023-10-11" @default.
- W2012753961 title "Negative Control of p53 by Sir2α Promotes Cell Survival under Stress" @default.
- W2012753961 cites W1493846190 @default.
- W2012753961 cites W1531643369 @default.
- W2012753961 cites W1547619885 @default.
- W2012753961 cites W1548972556 @default.
- W2012753961 cites W1551252878 @default.
- W2012753961 cites W1565881767 @default.
- W2012753961 cites W1587445693 @default.
- W2012753961 cites W1650797637 @default.
- W2012753961 cites W1951075546 @default.
- W2012753961 cites W1971215274 @default.
- W2012753961 cites W1974890383 @default.
- W2012753961 cites W1975392742 @default.
- W2012753961 cites W1978518304 @default.
- W2012753961 cites W1979962552 @default.
- W2012753961 cites W1985308585 @default.
- W2012753961 cites W1987738803 @default.
- W2012753961 cites W1991494214 @default.
- W2012753961 cites W1997388033 @default.
- W2012753961 cites W2001124416 @default.
- W2012753961 cites W2008715871 @default.
- W2012753961 cites W2012859476 @default.
- W2012753961 cites W2014228869 @default.
- W2012753961 cites W2017525855 @default.
- W2012753961 cites W2041959419 @default.
- W2012753961 cites W2044578262 @default.
- W2012753961 cites W2049094938 @default.
- W2012753961 cites W2051152566 @default.
- W2012753961 cites W2051915376 @default.
- W2012753961 cites W2052815426 @default.
- W2012753961 cites W2054696920 @default.
- W2012753961 cites W2056827933 @default.
- W2012753961 cites W2057654105 @default.
- W2012753961 cites W2085195718 @default.
- W2012753961 cites W2092722802 @default.
- W2012753961 cites W2096501714 @default.
- W2012753961 cites W2097948853 @default.
- W2012753961 cites W2112968535 @default.
- W2012753961 cites W2119363024 @default.
- W2012753961 cites W2124595934 @default.
- W2012753961 cites W2131019865 @default.
- W2012753961 cites W2135730738 @default.
- W2012753961 cites W2136280919 @default.
- W2012753961 cites W2144919418 @default.
- W2012753961 cites W2154986076 @default.
- W2012753961 cites W2157023326 @default.
- W2012753961 cites W2158005145 @default.
- W2012753961 cites W2165209574 @default.
- W2012753961 doi "https://doi.org/10.1016/s0092-8674(01)00524-4" @default.
- W2012753961 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11672522" @default.
- W2012753961 hasPublicationYear "2001" @default.
- W2012753961 type Work @default.
- W2012753961 sameAs 2012753961 @default.
- W2012753961 citedByCount "1979" @default.
- W2012753961 countsByYear W20127539612012 @default.
- W2012753961 countsByYear W20127539612013 @default.
- W2012753961 countsByYear W20127539612014 @default.
- W2012753961 countsByYear W20127539612015 @default.
- W2012753961 countsByYear W20127539612016 @default.
- W2012753961 countsByYear W20127539612017 @default.
- W2012753961 countsByYear W20127539612018 @default.
- W2012753961 countsByYear W20127539612019 @default.
- W2012753961 countsByYear W20127539612020 @default.
- W2012753961 countsByYear W20127539612021 @default.
- W2012753961 countsByYear W20127539612022 @default.
- W2012753961 countsByYear W20127539612023 @default.
- W2012753961 crossrefType "journal-article" @default.
- W2012753961 hasAuthorship W2012753961A5005092860 @default.
- W2012753961 hasAuthorship W2012753961A5013771208 @default.
- W2012753961 hasAuthorship W2012753961A5015664805 @default.
- W2012753961 hasAuthorship W2012753961A5020739926 @default.
- W2012753961 hasAuthorship W2012753961A5036476031 @default.
- W2012753961 hasAuthorship W2012753961A5039267744 @default.
- W2012753961 hasAuthorship W2012753961A5059235641 @default.
- W2012753961 hasAuthorship W2012753961A5081413351 @default.
- W2012753961 hasBestOaLocation W20127539611 @default.
- W2012753961 hasConcept C104317684 @default.
- W2012753961 hasConcept C119056186 @default.
- W2012753961 hasConcept C119157956 @default.
- W2012753961 hasConcept C143065580 @default.
- W2012753961 hasConcept C143425029 @default.
- W2012753961 hasConcept C181199279 @default.
- W2012753961 hasConcept C190283241 @default.
- W2012753961 hasConcept C199848840 @default.
- W2012753961 hasConcept C2776151105 @default.
- W2012753961 hasConcept C2777595374 @default.