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- W2012757894 abstract "The effect of the liver on the activity of streptokinase (Streptase TM) was studied using the isolated perfused rat liver. Perfusing medium consisted of either heparinized blood or a buffered dextran solution containing red blood cells. Experiments were performed in which streptokinase was given as a bolus or not given at all. It was found that fibrinolytic activity was greatly increased in the liver and bile after the administration of streptokinase using either medium. Fibrinolytic activity in the perfusate remained unchanged in experiments that did not have a liver in the perfusion circuit; however, when the liver was connected into the system, there was a tenfold prolongation of the lysis time. This supports the contention that the liver has an important role to play in the control of fibrinolysis because, besides decreasing the potential of streptokinase induced fibrinolysis, there was a synchronous increased excretion of fibrinolytic activity into the bile." @default.
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- W2012757894 date "1979-01-01" @default.
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- W2012757894 title "Comparative effects of an erythrocyte enriched synthetic replenisher and whole blood on streptokinase activity in the isolated perfused liver" @default.
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- W2012757894 doi "https://doi.org/10.1016/0049-3848(79)90031-8" @default.
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