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- W2012759035 abstract "The hippocampus is one of the most age-sensitive brain regions, yet the mechanisms of hippocampal shrinkage remain unclear. Recent studies suggest that hippocampal subfields are differentially vulnerable to aging and differentially sensitive to vascular risk. Promoters of inflammation are frequently proposed as major contributors to brain aging and vascular disease but their effects on hippocampal subfields are unknown. We examined the associations of hippocampal subfield volumes with age, a vascular risk factor (hypertension), and genetic polymorphisms associated with variation in pro-inflammatory cytokines levels (IL-1β C-511T and IL-6 C-174G) and risk for Alzheimer’s disease (APOEε4) in healthy adult volunteers (N = 80; age = 22–82 years). Volumes of three hippocampal subfields, cornu ammonis (CA) 1–2, CA3–dentate gyrus, and the subiculum were manually measured on high-resolution magnetic resonance images. Advanced age was differentially associated with smaller volume of CA1–2, whereas carriers of the T allele of IL-1β C-511T polymorphism had smaller volume of all hippocampal subfields than CC homozygotes did. Neither of the other genetic variants, nor diagnosis of hypertension, was associated with any of the measured volumes. The results support the notion that volumes of age-sensitive brain regions may be affected by pro-inflammatory factors that may be targeted by therapeutic interventions." @default.
- W2012759035 created "2016-06-24" @default.
- W2012759035 creator A5001741472 @default.
- W2012759035 creator A5001775831 @default.
- W2012759035 creator A5050123984 @default.
- W2012759035 creator A5060251321 @default.
- W2012759035 creator A5072388417 @default.
- W2012759035 date "2014-06-20" @default.
- W2012759035 modified "2023-09-25" @default.
- W2012759035 title "Volume of the hippocampal subfields in healthy adults: differential associations with age and a pro-inflammatory genetic variant" @default.
- W2012759035 cites W1496823793 @default.
- W2012759035 cites W1506252725 @default.
- W2012759035 cites W1552209891 @default.
- W2012759035 cites W1847168837 @default.
- W2012759035 cites W1849104917 @default.
- W2012759035 cites W1885605401 @default.
- W2012759035 cites W1930783699 @default.
- W2012759035 cites W1964806150 @default.
- W2012759035 cites W1968563535 @default.
- W2012759035 cites W1969001168 @default.
- W2012759035 cites W1972146634 @default.
- W2012759035 cites W1972696558 @default.
- W2012759035 cites W1976571725 @default.
- W2012759035 cites W1980872339 @default.
- W2012759035 cites W1983259675 @default.
- W2012759035 cites W1983687430 @default.
- W2012759035 cites W1984718847 @default.
- W2012759035 cites W1984748043 @default.
- W2012759035 cites W1987730138 @default.
- W2012759035 cites W1989369404 @default.
- W2012759035 cites W1993537924 @default.
- W2012759035 cites W1998040264 @default.
- W2012759035 cites W2000763052 @default.
- W2012759035 cites W2004225262 @default.
- W2012759035 cites W2004251450 @default.
- W2012759035 cites W2004973724 @default.
- W2012759035 cites W2006716233 @default.
- W2012759035 cites W2008205703 @default.
- W2012759035 cites W2010397126 @default.
- W2012759035 cites W2010767183 @default.
- W2012759035 cites W2010825610 @default.
- W2012759035 cites W2011812923 @default.
- W2012759035 cites W2013803050 @default.
- W2012759035 cites W2014441541 @default.
- W2012759035 cites W2020402140 @default.
- W2012759035 cites W2020935778 @default.
- W2012759035 cites W2020987343 @default.
- W2012759035 cites W2028126131 @default.
- W2012759035 cites W2031549819 @default.
- W2012759035 cites W2031809301 @default.
- W2012759035 cites W2034932339 @default.
- W2012759035 cites W2034968148 @default.
- W2012759035 cites W2035284177 @default.
- W2012759035 cites W2035888786 @default.
- W2012759035 cites W2036956824 @default.
- W2012759035 cites W2040423913 @default.
- W2012759035 cites W2040472175 @default.
- W2012759035 cites W2040654348 @default.
- W2012759035 cites W2041576587 @default.
- W2012759035 cites W2041680657 @default.
- W2012759035 cites W2042513568 @default.
- W2012759035 cites W2044270340 @default.
- W2012759035 cites W2050954407 @default.
- W2012759035 cites W2054947287 @default.
- W2012759035 cites W2056397762 @default.
- W2012759035 cites W2056709367 @default.
- W2012759035 cites W2063885731 @default.
- W2012759035 cites W2066137844 @default.
- W2012759035 cites W2066644955 @default.
- W2012759035 cites W2069465895 @default.
- W2012759035 cites W2070914392 @default.
- W2012759035 cites W2071881327 @default.
- W2012759035 cites W2076646757 @default.
- W2012759035 cites W2077816250 @default.
- W2012759035 cites W2078799316 @default.
- W2012759035 cites W2079834962 @default.
- W2012759035 cites W2080676389 @default.
- W2012759035 cites W2082402714 @default.
- W2012759035 cites W2087310074 @default.
- W2012759035 cites W2089309571 @default.
- W2012759035 cites W2089442400 @default.
- W2012759035 cites W2094338525 @default.
- W2012759035 cites W2095102390 @default.
- W2012759035 cites W2099157718 @default.
- W2012759035 cites W2099516158 @default.
- W2012759035 cites W2103069600 @default.
- W2012759035 cites W2103297806 @default.
- W2012759035 cites W2109989539 @default.
- W2012759035 cites W2111185373 @default.
- W2012759035 cites W2112778345 @default.
- W2012759035 cites W2114038005 @default.
- W2012759035 cites W2118110686 @default.
- W2012759035 cites W2118884820 @default.
- W2012759035 cites W2129092558 @default.
- W2012759035 cites W2133616653 @default.
- W2012759035 cites W2136022845 @default.
- W2012759035 cites W2140174213 @default.
- W2012759035 cites W2140636567 @default.