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• W2012761399 abstract "Two cooperating retinoic acid response elements (RAREs) in the cellular retinoic acid-binding protein II (CRABPII) gene mediate differential transcriptional transactivation by retinoic acid receptors (RARs) and retinoid X receptors (RXRs) in P19 embryonal carcinoma cells. RARE1 and RARE2 are direct repeats (DR) of two motifs separated by 2 bp (DR2) and 1 bp (DR1), respectively, and bind RAR-RXR heterodimers more efficiently than homodimers. Using all-trans and 9-cis RA, which differentially activate RARs and RXRs, and RAR and RXR dominant-negative mutants, RAR-RXR heterodimers bound to RARE1 and RARE2 are shown to be responsible for CRABPII promoter transactivation, arguing against a unique DR spacing specifying recognition by RARs. Within heterodimers, RAR and RXR independently and differentially transactivate, depending on the specific RARE. Consistent with these results, 9-cis RA increases CRABPII mRNA levels more efficiently than all-trans RA. In contrast, all-trans and 9-cis RA have identical effects on induction of RARβ2 transcripts." @default.
• W2012761399 created "2016-06-24" @default.
• W2012761399 creator A5010884420 @default.
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• W2012761399 creator A5085761422 @default.
• W2012761399 date "1992-10-01" @default.
• W2012761399 modified "2023-10-18" @default.
• W2012761399 title "All-trans and 9-cis retinoic acid induction of CRABPII transcription is mediated by RAR-RXR heterodimers bound to DR1 and DR2 repeated motifs" @default.
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• W2012761399 doi "https://doi.org/10.1016/0092-8674(92)90267-g" @default.
• W2012761399 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1327537" @default.
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