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• W2012765546 abstract "For many years virulence of pathogenic Entamoeba histolytica has been attributed to the capacity of the parasite to destroy tissues through the expression and/or secretion of various molecules. Such view is supported mainly by in vitro experimentation, whereas data obtained by using animal models of the disease have clearly demonstrated that the host's inflammatory response is primarily responsible for tissue damage. This review analyzes the content and/or activity of some of the presumed toxic amebic molecules present in amebic strains with different degrees of virulence compared to various parasite in vitro functions that are supposed to correlate with in vivo virulence. The analysis suggests that amebic virulence is primarily determined by the parasite's capacity to adapt and survive the aerobic conditions present in animal tissues. This initial episode in the host-parasite relationship is an absolute requirement for the further development of tissue lesions, which result from the concerted action of many molecules derived from both, the host and the parasite." @default.
• W2012765546 created "2016-06-24" @default.
• W2012765546 creator A5002401572 @default.
• W2012765546 creator A5002898170 @default.
• W2012765546 creator A5044587069 @default.
• W2012765546 creator A5046995542 @default.
• W2012765546 creator A5067519351 @default.
• W2012765546 date "2009-12-01" @default.
• W2012765546 modified "2023-10-03" @default.
• W2012765546 title "Molecular nature of virulence in Entamoeba histolytica" @default.
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• W2012765546 doi "https://doi.org/10.1016/j.meegid.2009.04.005" @default.
• W2012765546 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19376272" @default.
• W2012765546 hasPublicationYear "2009" @default.
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