FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012769387> ?p ?o ?g. }

• W2012769387 endingPage "1169" @default.
• W2012769387 startingPage "1164" @default.
• W2012769387 abstract "Phthalates are industrial chemicals widely used in many commercial applications. The general population is exposed to phthalates through consumer products as well as through diet and medical treatments. To determine whether environmental levels of phthalates are associated with altered DNA integrity in human sperm, we selected a population without identified sources of exposure to phthalates. One hundred sixty-eight subjects recruited from the Massachusetts General Hospital Andrology Laboratory provided a semen and a urine sample. Eight phthalate metabolites were measured in urine by using high-performance liquid chromatography and tandem mass spectrometry; data were corrected for urine dilution by adjusting for specific gravity. The neutral single-cell microgel electrophoresis assay (comet assay) was used to measure DNA integrity in sperm. VisComet image analysis software was used to measure comet extent, a measure of total comet length (micrometers); percent DNA in tail (tail%), a measure of the proportion of total DNA present in the comet tail; and tail distributed moment (TDM), an integrated measure of length and intensity (micrometers). For an interquartile range increase in specific gravity-adjusted monoethyl phthalate (MEP) level, the comet extent increased significantly by 3.6 micro m [95% confidence interval (95% CI), 0.74-6.47]; the TDM also increased 1.2 micro m (95% CI, -0.05 to 2.38) but was of borderline significance. Monobutyl, monobenzyl, monomethyl, and mono-2-ethylhexyl phthalates were not significantly associated with comet assay parameters. In conclusion, this study represents the first human data to demonstrate that urinary MEP, at environmental levels, is associated with increased DNA damage in sperm." @default.
• W2012769387 created "2016-06-24" @default.
• W2012769387 creator A5013540878 @default.
• W2012769387 creator A5017911709 @default.
• W2012769387 creator A5029868654 @default.
• W2012769387 creator A5036897140 @default.
• W2012769387 creator A5040438950 @default.
• W2012769387 creator A5056478559 @default.
• W2012769387 creator A5065230464 @default.
• W2012769387 creator A5082642762 @default.
• W2012769387 creator A5091331939 @default.
• W2012769387 date "2003-07-01" @default.
• W2012769387 modified "2023-10-15" @default.
• W2012769387 title "The relationship between environmental exposures to phthalates and DNA damage in human sperm using the neutral comet assay." @default.
• W2012769387 cites W142722182 @default.
• W2012769387 cites W1972241196 @default.
• W2012769387 cites W1974149498 @default.
• W2012769387 cites W1975615286 @default.
• W2012769387 cites W1985712542 @default.
• W2012769387 cites W1991455005 @default.
• W2012769387 cites W2006450021 @default.
• W2012769387 cites W2008998922 @default.
• W2012769387 cites W2021363087 @default.
• W2012769387 cites W2021998511 @default.
• W2012769387 cites W2022108309 @default.
• W2012769387 cites W2032704919 @default.
• W2012769387 cites W2046571272 @default.
• W2012769387 cites W2048401878 @default.
• W2012769387 cites W2048987357 @default.
• W2012769387 cites W2051871622 @default.
• W2012769387 cites W2053501212 @default.
• W2012769387 cites W2065075421 @default.
• W2012769387 cites W2065465793 @default.
• W2012769387 cites W2072027923 @default.
• W2012769387 cites W2073924643 @default.
• W2012769387 cites W2084026465 @default.
• W2012769387 cites W2084811597 @default.
• W2012769387 cites W2087416821 @default.
• W2012769387 cites W2090168250 @default.
• W2012769387 cites W2092629964 @default.
• W2012769387 cites W2097972057 @default.
• W2012769387 cites W2109269254 @default.
• W2012769387 cites W2121958705 @default.
• W2012769387 cites W2122285171 @default.
• W2012769387 cites W2143653306 @default.
• W2012769387 cites W2153763209 @default.
• W2012769387 cites W2157936339 @default.
• W2012769387 cites W2161372778 @default.
• W2012769387 cites W2621984490 @default.
• W2012769387 doi "https://doi.org/10.1289/ehp.5756" @default.
• W2012769387 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1241569" @default.
• W2012769387 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12842768" @default.
• W2012769387 hasPublicationYear "2003" @default.
• W2012769387 type Work @default.
• W2012769387 sameAs 2012769387 @default.
• W2012769387 citedByCount "277" @default.
• W2012769387 countsByYear W20127693872012 @default.
• W2012769387 countsByYear W20127693872013 @default.
• W2012769387 countsByYear W20127693872014 @default.
• W2012769387 countsByYear W20127693872015 @default.
• W2012769387 countsByYear W20127693872016 @default.
• W2012769387 countsByYear W20127693872017 @default.
• W2012769387 countsByYear W20127693872018 @default.
• W2012769387 countsByYear W20127693872019 @default.
• W2012769387 countsByYear W20127693872020 @default.
• W2012769387 countsByYear W20127693872021 @default.
• W2012769387 countsByYear W20127693872022 @default.
• W2012769387 countsByYear W20127693872023 @default.
• W2012769387 crossrefType "journal-article" @default.
• W2012769387 hasAuthorship W2012769387A5013540878 @default.
• W2012769387 hasAuthorship W2012769387A5017911709 @default.
• W2012769387 hasAuthorship W2012769387A5029868654 @default.
• W2012769387 hasAuthorship W2012769387A5036897140 @default.
• W2012769387 hasAuthorship W2012769387A5040438950 @default.
• W2012769387 hasAuthorship W2012769387A5056478559 @default.
• W2012769387 hasAuthorship W2012769387A5065230464 @default.
• W2012769387 hasAuthorship W2012769387A5082642762 @default.
• W2012769387 hasAuthorship W2012769387A5091331939 @default.
• W2012769387 hasBestOaLocation W20127693871 @default.
• W2012769387 hasConcept C119060515 @default.
• W2012769387 hasConcept C126322002 @default.
• W2012769387 hasConcept C143425029 @default.
• W2012769387 hasConcept C16685009 @default.
• W2012769387 hasConcept C178790620 @default.
• W2012769387 hasConcept C185592680 @default.
• W2012769387 hasConcept C2780026642 @default.
• W2012769387 hasConcept C2780358455 @default.
• W2012769387 hasConcept C2781005124 @default.
• W2012769387 hasConcept C2781087480 @default.
• W2012769387 hasConcept C2908647359 @default.
• W2012769387 hasConcept C33070731 @default.
• W2012769387 hasConcept C43617362 @default.
• W2012769387 hasConcept C552990157 @default.
• W2012769387 hasConcept C55493867 @default.
• W2012769387 hasConcept C71924100 @default.
• W2012769387 hasConcept C86803240 @default.
• W2012769387 hasConcept C87355193 @default.
• W2012769387 hasConcept C94081185 @default.

• next