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• W2012769719 abstract "In the present study, we examined the specific binding of IGF-I and IGF-II to their receptors in C6 glioma cells taken during different growth phases in culture: phase A, early stage of the exponential growth (48 h after seeding); phase B, late stage of the exponential phase (96 h after seeding); phase C, confluent phase (at 144 h after seeding); and phase D, stopped at 48 h post-confluence. Scatchard analysis revealed higher Ka values for the IGF-IR during the exponential phases (A and B). The affinity of IGF-I for its receptor during the post-confluent phase (D) decreased to about half that at phase A (p < 0.01). Although lower at the later phase (D), the number of binding sites of the IGF-IR in the different tested growth stages in culture (A, B, and C) was not statistically different (p > 0.05). Conversely, the number of binding sites of the IGF-II/mannose-6-phosphate receptor appeared to increase during time in culture. The Ka values of the IGF-II/mannose-6-phosphate receptor decreased significantly during the culture time, phase D showing the largest decrease (50%) as compared with phase A (p < 0.005). These binding data suggest that IGF-I and IGF-II receptors are differentially expressed in rat C6 glioma cells in culture and are a function of the growth phase." @default.
• W2012769719 created "2016-06-24" @default.
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• W2012769719 date "1998-01-01" @default.
• W2012769719 modified "2023-09-23" @default.
• W2012769719 title "Expression of IGF-I and IGF-II Receptors in Rat C6 Glioma Cells as a Function of the Growth Phase" @default.
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• W2012769719 doi "https://doi.org/10.1159/000016292" @default.
• W2012769719 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9949256" @default.
• W2012769719 hasPublicationYear "1998" @default.
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