Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012773090> ?p ?o ?g. }
- W2012773090 endingPage "758" @default.
- W2012773090 startingPage "758" @default.
- W2012773090 abstract "To understand the earliest signs of cognitive decline caused by Alzheimer disease (AD) and other illnesses causing dementia, information is needed from well-characterized individuals without dementia studied longitudinally until autopsy.To determine clinical and cognitive features associated with the development of AD or other dementias in older adults.Longitudinal study of memory and aging.Alzheimer's Disease Research Center, St Louis, Mo.Clinical Dementia Rating, its sum of boxes, and neuropathologic diagnosis of dementia.Eighty control participants who eventually came to autopsy.Individuals who did not develop dementia showed stable cognitive performance. Entry predictors of dementia were age, deficits in problem solving as well as memory, slowed psychomotor performance, and depressive features. Minimal cognitive decline occurred prior to dementia diagnosis, after which sharp decline was noted. Even individuals who were minimally cognitively impaired (Clinical Dementia Rating = 0.5) typically had neuropathologic AD at autopsy. Histopathologic AD also was present in 34% of individuals who did not have dementia at death; these individuals without dementia showed an absence of practice effects on cognitive testing.Increased age, depressive features, and even minimal cognitive impairment, as determined clinically by Clinical Dementia Rating sum of boxes and by slowed psychomotor performance, identify older individuals without dementia who develop dementia. Older adults who do not develop dementia have stable cognitive performance. The absence of practice effects may denote the subset of older adults without dementia with histopathologic AD, which may reflect a preclinical stage of the illness." @default.
- W2012773090 created "2016-06-24" @default.
- W2012773090 creator A5002737798 @default.
- W2012773090 creator A5016547093 @default.
- W2012773090 creator A5035514608 @default.
- W2012773090 creator A5048202809 @default.
- W2012773090 creator A5063630764 @default.
- W2012773090 creator A5071146971 @default.
- W2012773090 creator A5080654936 @default.
- W2012773090 creator A5084326649 @default.
- W2012773090 date "2005-05-01" @default.
- W2012773090 modified "2023-10-12" @default.
- W2012773090 title "Predictors of Preclinical Alzheimer Disease and Dementia" @default.
- W2012773090 cites W1614256764 @default.
- W2012773090 cites W1847168837 @default.
- W2012773090 cites W1968832539 @default.
- W2012773090 cites W1971744915 @default.
- W2012773090 cites W1972340735 @default.
- W2012773090 cites W1975505777 @default.
- W2012773090 cites W1981802311 @default.
- W2012773090 cites W1983611639 @default.
- W2012773090 cites W1985621046 @default.
- W2012773090 cites W1986852667 @default.
- W2012773090 cites W1991952617 @default.
- W2012773090 cites W1992974274 @default.
- W2012773090 cites W2006933389 @default.
- W2012773090 cites W2010846286 @default.
- W2012773090 cites W2025290060 @default.
- W2012773090 cites W2049155848 @default.
- W2012773090 cites W2055101973 @default.
- W2012773090 cites W2088584394 @default.
- W2012773090 cites W2092129469 @default.
- W2012773090 cites W2112150247 @default.
- W2012773090 cites W2113708991 @default.
- W2012773090 cites W2115077024 @default.
- W2012773090 cites W2123056519 @default.
- W2012773090 cites W2123535374 @default.
- W2012773090 cites W2149614271 @default.
- W2012773090 cites W2156220037 @default.
- W2012773090 cites W2157299685 @default.
- W2012773090 cites W2157359173 @default.
- W2012773090 cites W2334899545 @default.
- W2012773090 cites W2725718031 @default.
- W2012773090 doi "https://doi.org/10.1001/archneur.62.5.758" @default.
- W2012773090 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15883263" @default.
- W2012773090 hasPublicationYear "2005" @default.
- W2012773090 type Work @default.
- W2012773090 sameAs 2012773090 @default.
- W2012773090 citedByCount "187" @default.
- W2012773090 countsByYear W20127730902012 @default.
- W2012773090 countsByYear W20127730902013 @default.
- W2012773090 countsByYear W20127730902014 @default.
- W2012773090 countsByYear W20127730902015 @default.
- W2012773090 countsByYear W20127730902016 @default.
- W2012773090 countsByYear W20127730902017 @default.
- W2012773090 countsByYear W20127730902018 @default.
- W2012773090 countsByYear W20127730902019 @default.
- W2012773090 countsByYear W20127730902020 @default.
- W2012773090 countsByYear W20127730902021 @default.
- W2012773090 countsByYear W20127730902022 @default.
- W2012773090 countsByYear W20127730902023 @default.
- W2012773090 crossrefType "journal-article" @default.
- W2012773090 hasAuthorship W2012773090A5002737798 @default.
- W2012773090 hasAuthorship W2012773090A5016547093 @default.
- W2012773090 hasAuthorship W2012773090A5035514608 @default.
- W2012773090 hasAuthorship W2012773090A5048202809 @default.
- W2012773090 hasAuthorship W2012773090A5063630764 @default.
- W2012773090 hasAuthorship W2012773090A5071146971 @default.
- W2012773090 hasAuthorship W2012773090A5080654936 @default.
- W2012773090 hasAuthorship W2012773090A5084326649 @default.
- W2012773090 hasConcept C118552586 @default.
- W2012773090 hasConcept C126322002 @default.
- W2012773090 hasConcept C15744967 @default.
- W2012773090 hasConcept C164953862 @default.
- W2012773090 hasConcept C169900460 @default.
- W2012773090 hasConcept C2779134260 @default.
- W2012773090 hasConcept C2779483572 @default.
- W2012773090 hasConcept C2779504383 @default.
- W2012773090 hasConcept C2780130745 @default.
- W2012773090 hasConcept C2780906993 @default.
- W2012773090 hasConcept C2984863031 @default.
- W2012773090 hasConcept C502032728 @default.
- W2012773090 hasConcept C71924100 @default.
- W2012773090 hasConcept C74909509 @default.
- W2012773090 hasConceptScore W2012773090C118552586 @default.
- W2012773090 hasConceptScore W2012773090C126322002 @default.
- W2012773090 hasConceptScore W2012773090C15744967 @default.
- W2012773090 hasConceptScore W2012773090C164953862 @default.
- W2012773090 hasConceptScore W2012773090C169900460 @default.
- W2012773090 hasConceptScore W2012773090C2779134260 @default.
- W2012773090 hasConceptScore W2012773090C2779483572 @default.
- W2012773090 hasConceptScore W2012773090C2779504383 @default.
- W2012773090 hasConceptScore W2012773090C2780130745 @default.
- W2012773090 hasConceptScore W2012773090C2780906993 @default.
- W2012773090 hasConceptScore W2012773090C2984863031 @default.
- W2012773090 hasConceptScore W2012773090C502032728 @default.
- W2012773090 hasConceptScore W2012773090C71924100 @default.
- W2012773090 hasConceptScore W2012773090C74909509 @default.