FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012783173> ?p ?o ?g. }

• W2012783173 endingPage "117" @default.
• W2012783173 startingPage "112" @default.
• W2012783173 abstract "Activation of c-fos, an immediate early gene, and the subsequent upregulation of Fos protein expression occur following neural injury, including focal cerebral ischemia (fci). Fos and Jun form a heterodimer known as activator protein 1, which regulates the expression of many late effector genes. To study the downstream effects of c-fos expression following ischemia, we suppressed the translation of c-fos by administering an antisense oligonucleotide (AO) to c-fos mRNA. Eighteen hours prior to fci, male, Long Evans (LE) rats received intraventricular injections of AO, mismatched AO (MS) or artificial cerebrospinal fluid (aCSF). Fci was induced by permanent right middle cerebral artery occlusion. At 24-h post-occlusion, neurological function was assessed, and the animals were sacrificed. The brains were removed and stained with triphenyltetrazolium chloride for infarct volume determination. Fos immunohistochemistry was performed in separate animals to determine the effects of treatment on Fos expression number of Fos positive cells. AO administration reduced the number of cells with fci-induced Fos expression by approximately 75%. No differences in neurological scores existed between any of the groups. AO-treated LE developed larger infarcts (40.1+/-1.0%, mean+/-S.D., p<0.001) than MS- or aCSF-treated controls (34.3+/-1.0%, 34.6+/-1.0%, respectively). These results suggest that c-fos activation and subsequent Fos protein expression exerts a neuroprotective effect, which is likely via upregulation of neurotrophins, following focal cerebral ischemia. This response, among others, may contribute to brain adaptation to injury that underlies functional recovery after stroke." @default.
• W2012783173 created "2016-06-24" @default.
• W2012783173 creator A5014361138 @default.
• W2012783173 creator A5066435409 @default.
• W2012783173 creator A5069862802 @default.
• W2012783173 creator A5069998165 @default.
• W2012783173 creator A5082672299 @default.
• W2012783173 date "1999-06-01" @default.
• W2012783173 modified "2023-10-10" @default.
• W2012783173 title "Suppression of post-ischemic-induced Fos protein expression by an antisense oligonucleotide to c-fos mRNA leads to increased tissue damage" @default.
• W2012783173 cites W1500101213 @default.
• W2012783173 cites W1555267448 @default.
• W2012783173 cites W1752221293 @default.
• W2012783173 cites W1871934956 @default.
• W2012783173 cites W1968157356 @default.
• W2012783173 cites W1968847695 @default.
• W2012783173 cites W1969343305 @default.
• W2012783173 cites W1969949240 @default.
• W2012783173 cites W1971159711 @default.
• W2012783173 cites W1974844063 @default.
• W2012783173 cites W1975221200 @default.
• W2012783173 cites W1984389527 @default.
• W2012783173 cites W2000113922 @default.
• W2012783173 cites W2000371106 @default.
• W2012783173 cites W2002412570 @default.
• W2012783173 cites W2006363888 @default.
• W2012783173 cites W2007879707 @default.
• W2012783173 cites W2012383791 @default.
• W2012783173 cites W2012813919 @default.
• W2012783173 cites W2013926808 @default.
• W2012783173 cites W2017053170 @default.
• W2012783173 cites W2023093915 @default.
• W2012783173 cites W2027840396 @default.
• W2012783173 cites W2029808323 @default.
• W2012783173 cites W2033679557 @default.
• W2012783173 cites W2037702964 @default.
• W2012783173 cites W2040113888 @default.
• W2012783173 cites W2041169617 @default.
• W2012783173 cites W2046721940 @default.
• W2012783173 cites W2047480541 @default.
• W2012783173 cites W2047517642 @default.
• W2012783173 cites W2048890514 @default.
• W2012783173 cites W2051091654 @default.
• W2012783173 cites W2055257235 @default.
• W2012783173 cites W2057094603 @default.
• W2012783173 cites W2058744360 @default.
• W2012783173 cites W2060188519 @default.
• W2012783173 cites W2063842801 @default.
• W2012783173 cites W2067193940 @default.
• W2012783173 cites W2068225545 @default.
• W2012783173 cites W2068230814 @default.
• W2012783173 cites W2068665571 @default.
• W2012783173 cites W2070739743 @default.
• W2012783173 cites W2073383715 @default.
• W2012783173 cites W2088155527 @default.
• W2012783173 cites W2091599040 @default.
• W2012783173 cites W2094973947 @default.
• W2012783173 cites W2124341104 @default.
• W2012783173 cites W2125683177 @default.
• W2012783173 cites W2136024488 @default.
• W2012783173 cites W2147741867 @default.
• W2012783173 cites W2156253520 @default.
• W2012783173 cites W4240511213 @default.
• W2012783173 cites W6973128 @default.
• W2012783173 doi "https://doi.org/10.1016/s0006-8993(99)01459-6" @default.
• W2012783173 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10375656" @default.
• W2012783173 hasPublicationYear "1999" @default.
• W2012783173 type Work @default.
• W2012783173 sameAs 2012783173 @default.
• W2012783173 citedByCount "33" @default.
• W2012783173 countsByYear W20127831732012 @default.
• W2012783173 countsByYear W20127831732013 @default.
• W2012783173 countsByYear W20127831732014 @default.
• W2012783173 countsByYear W20127831732015 @default.
• W2012783173 countsByYear W20127831732021 @default.
• W2012783173 countsByYear W20127831732022 @default.
• W2012783173 crossrefType "journal-article" @default.
• W2012783173 hasAuthorship W2012783173A5014361138 @default.
• W2012783173 hasAuthorship W2012783173A5066435409 @default.
• W2012783173 hasAuthorship W2012783173A5069862802 @default.
• W2012783173 hasAuthorship W2012783173A5069998165 @default.
• W2012783173 hasAuthorship W2012783173A5082672299 @default.
• W2012783173 hasConcept C104317684 @default.
• W2012783173 hasConcept C105580179 @default.
• W2012783173 hasConcept C126322002 @default.
• W2012783173 hasConcept C127561419 @default.
• W2012783173 hasConcept C134018914 @default.
• W2012783173 hasConcept C150194340 @default.
• W2012783173 hasConcept C25498285 @default.
• W2012783173 hasConcept C2777099045 @default.
• W2012783173 hasConcept C2778820722 @default.
• W2012783173 hasConcept C2779555244 @default.
• W2012783173 hasConcept C2780323455 @default.
• W2012783173 hasConcept C42219234 @default.
• W2012783173 hasConcept C541997718 @default.
• W2012783173 hasConcept C55493867 @default.
• W2012783173 hasConcept C71924100 @default.
• W2012783173 hasConcept C86803240 @default.

• next