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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012787235> ?p ?o ?g. }

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• W2012787235 abstract "A novel method for detecting interaction between DNA and DNA-binding protein at single molecular level has been proposed. In this study, estrogen receptor-alpha (ER-alpha) was used for biosensing as the proof-example. A 518 bp-long (ca. 176 nm) DNA probe labeled with streptavidin at its 5'-terminus was prepared by inserting a consensus oligonucleotide sequence that binds to ER-alpha. A solution containing ER-alpha was dropped onto the Ni-treated mica substrate on which the DNA prove was previously immobilized, and it was observed by AFM. Specific binding of ER-alpha could be observed by measuring the distance between the site where binding occur, to the streptavidin label." @default.
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• W2012787235 date "2004-07-01" @default.
• W2012787235 modified "2023-09-23" @default.
• W2012787235 title "On-chip biosensing of estrogen receptor-α at single molecular level" @default.
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• W2012787235 doi "https://doi.org/10.1016/j.bios.2003.12.028" @default.
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• W2012787235 hasPublicationYear "2004" @default.
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