FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012791778> ?p ?o ?g. }

• W2012791778 endingPage "374" @default.
• W2012791778 startingPage "367" @default.
• W2012791778 abstract "The mode of pharmacological healing influences subsequent ulcer relapse. Duodenal ulcer relapse following healing and withdrawal of active therapy has been studied in 18 prospectively randomised comparative studies involving cimetidine and alternative healing agents. Most studies (eleven of the 18) showed comparative agents with a lower (> 10%) incidence of relapse than cimetidine while a minority (seven of the 18) showed equal (±10%) relapse. The probability of this distribution occurring by chance is less than 1:1000 (p = 0.0005, sign test). In three of the 11 published comparative studies the relapse rate was significantly higher in those who had previously received cimetidine (p<0.05, two-sided significance test). This was despite the fact that most of the individual studies were small and required a substantial difference in results for the 5% significance level to be reached. Paired comparative incidences of relapse at six months were converted to relapse rates (percentage of healed population relapsing monthly), average rates for comparative agents were 8.05±2.7% while those for cimetidine were 16.9±4.4% (x±SEM, n = 5); cimetidine relapse rates derived from non-comparative trials were 17.0 ± 1.9% (x± SEM, n = 7). Higher relapse rates translate into larger numbers of patients at risk and in need of active therapy. These results are of biological and clinical significance. Differences in relapse must reflect beneficial effects of one group of agents on the ulcer diathesis or adverse effects of the comparator, cimetidine. Each alternative reflects negatively on cimetidine as an antiulcer medication; however, confirmation of adverse effects would force radical review of most current therapy of ulcer disease. Research into ulcer therapeutics must emphasise both the relapse and the healing potential of pharmacological agents. (Aust NZ J Med 1985; 15: 367–374.)" @default.
• W2012791778 created "2016-06-24" @default.
• W2012791778 creator A5009843825 @default.
• W2012791778 creator A5013922728 @default.
• W2012791778 creator A5026990977 @default.
• W2012791778 creator A5050992232 @default.
• W2012791778 creator A5051233756 @default.
• W2012791778 creator A5079904753 @default.
• W2012791778 date "1985-06-01" @default.
• W2012791778 modified "2023-10-16" @default.
• W2012791778 title "THE CHOICE OF ULCER HEALING AGENT INFLUENCES DUODENAL ULCER RELAPSE RATE AND LONG-TERM CLINICAL OUTCOME" @default.
• W2012791778 cites W1561568838 @default.
• W2012791778 cites W1567097454 @default.
• W2012791778 cites W1988336805 @default.
• W2012791778 cites W1988930563 @default.
• W2012791778 cites W1997613718 @default.
• W2012791778 cites W2002941535 @default.
• W2012791778 cites W2010794568 @default.
• W2012791778 cites W2020814633 @default.
• W2012791778 cites W2031184012 @default.
• W2012791778 cites W2047623819 @default.
• W2012791778 cites W2056431318 @default.
• W2012791778 cites W2060796759 @default.
• W2012791778 cites W2067990888 @default.
• W2012791778 cites W2075529594 @default.
• W2012791778 cites W2076493094 @default.
• W2012791778 cites W2087560168 @default.
• W2012791778 cites W2089870043 @default.
• W2012791778 cites W2126717820 @default.
• W2012791778 cites W2137375055 @default.
• W2012791778 cites W2414948815 @default.
• W2012791778 cites W2606927473 @default.
• W2012791778 cites W4237820590 @default.
• W2012791778 doi "https://doi.org/10.1111/j.1445-5994.1985.tb04065.x" @default.
• W2012791778 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3904700" @default.
• W2012791778 hasPublicationYear "1985" @default.
• W2012791778 type Work @default.
• W2012791778 sameAs 2012791778 @default.
• W2012791778 citedByCount "52" @default.
• W2012791778 crossrefType "journal-article" @default.
• W2012791778 hasAuthorship W2012791778A5009843825 @default.
• W2012791778 hasAuthorship W2012791778A5013922728 @default.
• W2012791778 hasAuthorship W2012791778A5026990977 @default.
• W2012791778 hasAuthorship W2012791778A5050992232 @default.
• W2012791778 hasAuthorship W2012791778A5051233756 @default.
• W2012791778 hasAuthorship W2012791778A5079904753 @default.
• W2012791778 hasConcept C120665830 @default.
• W2012791778 hasConcept C121332964 @default.
• W2012791778 hasConcept C126322002 @default.
• W2012791778 hasConcept C197934379 @default.
• W2012791778 hasConcept C2780719153 @default.
• W2012791778 hasConcept C2908647359 @default.
• W2012791778 hasConcept C2993747882 @default.
• W2012791778 hasConcept C535046627 @default.
• W2012791778 hasConcept C61511704 @default.
• W2012791778 hasConcept C65409693 @default.
• W2012791778 hasConcept C71924100 @default.
• W2012791778 hasConcept C90924648 @default.
• W2012791778 hasConcept C99454951 @default.
• W2012791778 hasConceptScore W2012791778C120665830 @default.
• W2012791778 hasConceptScore W2012791778C121332964 @default.
• W2012791778 hasConceptScore W2012791778C126322002 @default.
• W2012791778 hasConceptScore W2012791778C197934379 @default.
• W2012791778 hasConceptScore W2012791778C2780719153 @default.
• W2012791778 hasConceptScore W2012791778C2908647359 @default.
• W2012791778 hasConceptScore W2012791778C2993747882 @default.
• W2012791778 hasConceptScore W2012791778C535046627 @default.
• W2012791778 hasConceptScore W2012791778C61511704 @default.
• W2012791778 hasConceptScore W2012791778C65409693 @default.
• W2012791778 hasConceptScore W2012791778C71924100 @default.
• W2012791778 hasConceptScore W2012791778C90924648 @default.
• W2012791778 hasConceptScore W2012791778C99454951 @default.
• W2012791778 hasIssue "3" @default.
• W2012791778 hasLocation W20127917781 @default.
• W2012791778 hasLocation W20127917782 @default.
• W2012791778 hasOpenAccess W2012791778 @default.
• W2012791778 hasPrimaryLocation W20127917781 @default.
• W2012791778 hasRelatedWork W118964590 @default.
• W2012791778 hasRelatedWork W1802482312 @default.
• W2012791778 hasRelatedWork W186760032 @default.
• W2012791778 hasRelatedWork W1963786097 @default.
• W2012791778 hasRelatedWork W2163143709 @default.
• W2012791778 hasRelatedWork W2403476663 @default.
• W2012791778 hasRelatedWork W2405523221 @default.
• W2012791778 hasRelatedWork W2418753445 @default.
• W2012791778 hasRelatedWork W2419029695 @default.
• W2012791778 hasRelatedWork W2469715906 @default.
• W2012791778 hasVolume "15" @default.
• W2012791778 isParatext "false" @default.
• W2012791778 isRetracted "false" @default.
• W2012791778 magId "2012791778" @default.
• W2012791778 workType "article" @default.