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• W2012794026 abstract "The cellular uptake and laminar distribution of tritium-labeled gamma-aminobutyrate, aspartate, glutamate and glycine were examined in the primary visual cortex of squirrel monkeys. The purpose was to correlate the distribution of these labeled neurons with their level of cytochrome oxidase activity, particularly in laminae II-III (puffs) and adjacent non-puff regions. In general, tritium-labeled neurons that had either high or low levels of cytochrome oxidase activity were present in all laminae with each amino acid tested; however, their density varied between laminae and with the amino acid injected. Specifically, in laminae II-III, very few neurons were labelled with either of the putative excitatory amino acids (aspartate and glutamate). An increased uptake for both was observed in lamina IVC, with the greatest increase for each occurring in laminae V and VI. Significantly more neurons in each lamina were labeled with the putative inhibitory transmitters (gamma-aminobutyrate and glycine) than with either aspartate or glutamate. gamma-Aminobutyrate-labeled neurons were more prevalent in lamina II than III, and an increase in labeling was observed in laminae IV-VI, with the most prominent increase found in laminae V and VI. Glycine-labeled neurons were larger, more uniformly distributed and more abundant throughout all cortical laminae than those labeled with the other amino acids. Significantly more gamma-aminobutyrate- and glycine-labeled neurons were found in the puff regions than in the non-puff areas. No difference was found between puff and non-puff regions for the tritium-labeled leucine controls. Labeled neurons included stellate, fusiform and pyramidal-shaped cells of varying sizes; however, gamma-aminobutyrate-labeled pyramidal cells were not observed outside of the intense injection site. Large glycine-labeled cytochrome-oxidase-reactive pyramidal cells (24-32 micron in diameter) were present at the boundary between laminae V and VI. In addition, a row of large glycine-labeled, fusiform neurons were present in lamina IVB. With each amino acid injected, the tritium-labeled neurons that were darkly reactive for cytochrome oxidase were, on average, larger than the tritium-labeled neurons that were only lightly reactive for cytochrome oxidase. Thus, each of the four amino acids tested had its unique pattern of distribution in the primate striate cortex. Whether one or all of them served as neurotransmitter(s) for distinct neuronal groups is beyond the scope of this study. Glycine, in particular, might be used in part or in whole for metabolic purposes.(ABSTRACT TRUNCATED AT 400 WORDS)" @default.
• W2012794026 created "2016-06-24" @default.
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• W2012794026 date "1985-08-01" @default.
• W2012794026 modified "2023-09-25" @default.
• W2012794026 title "Correlation between cytochrome oxidase staining and the uptake and laminar distribution of tritiated aspartate, glutamate, γ-aminobutyrate and glycine in the striate cortex of the squirrel monkey" @default.
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• W2012794026 doi "https://doi.org/10.1016/0306-4522(85)90246-5" @default.
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