Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012797534> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2012797534 abstract "The anti-atherogenic effects of human apolipoprotein E3 (apoE3) have been partially attributed to its anti-proliferation properties. We studied if endogenously expressed apoE elicits isoform-dependent effects on cell proliferation. Rat F111 fibroblasts without native expression of apoE were used to establish cell lines with stable expression of the three human apoE isoforms. Cell growth curve studies showed that expression of apoE isoforms prolonged cell population doubling time in an isoform-dependent manner with apoE3 showing the most potent effect followed by apoE2 and apoE4 exhibiting comparable effects. Interestingly, saturation density of cell population was significantly reduced by the expression of apoE4 isofom. Further analyses revealed that all three apoE isoforms significantly lengthened G0/G1 phase (p < 0.05) of the cell cycle and were associated with the suppression of ERK1/2 activities. However, these changes were not sufficient to explain the isoform-dependent effects of apoE expression on cell population doubling time and saturation density." @default.
- W2012797534 created "2016-06-24" @default.
- W2012797534 creator A5008131664 @default.
- W2012797534 creator A5076402674 @default.
- W2012797534 date "2006-07-01" @default.
- W2012797534 modified "2023-10-14" @default.
- W2012797534 title "Inhibition of cell proliferation by apolipoprotein E isoform expression" @default.
- W2012797534 cites W1889797874 @default.
- W2012797534 cites W1971180770 @default.
- W2012797534 cites W1984888055 @default.
- W2012797534 cites W1989995470 @default.
- W2012797534 cites W2000951003 @default.
- W2012797534 cites W2002909248 @default.
- W2012797534 cites W2017397275 @default.
- W2012797534 cites W2020356020 @default.
- W2012797534 cites W2021304013 @default.
- W2012797534 cites W2027021224 @default.
- W2012797534 cites W2029007538 @default.
- W2012797534 cites W2034968148 @default.
- W2012797534 cites W2039158755 @default.
- W2012797534 cites W2046445606 @default.
- W2012797534 cites W2074223024 @default.
- W2012797534 cites W2078373625 @default.
- W2012797534 cites W2079517191 @default.
- W2012797534 cites W2081777955 @default.
- W2012797534 cites W2114063969 @default.
- W2012797534 cites W2121101037 @default.
- W2012797534 cites W2128324529 @default.
- W2012797534 doi "https://doi.org/10.1016/j.abb.2006.05.004" @default.
- W2012797534 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16780788" @default.
- W2012797534 hasPublicationYear "2006" @default.
- W2012797534 type Work @default.
- W2012797534 sameAs 2012797534 @default.
- W2012797534 citedByCount "2" @default.
- W2012797534 crossrefType "journal-article" @default.
- W2012797534 hasAuthorship W2012797534A5008131664 @default.
- W2012797534 hasAuthorship W2012797534A5076402674 @default.
- W2012797534 hasConcept C104317684 @default.
- W2012797534 hasConcept C126322002 @default.
- W2012797534 hasConcept C1491633281 @default.
- W2012797534 hasConcept C153911025 @default.
- W2012797534 hasConcept C185592680 @default.
- W2012797534 hasConcept C2779134260 @default.
- W2012797534 hasConcept C2908647359 @default.
- W2012797534 hasConcept C29537977 @default.
- W2012797534 hasConcept C53345823 @default.
- W2012797534 hasConcept C54355233 @default.
- W2012797534 hasConcept C55493867 @default.
- W2012797534 hasConcept C57089818 @default.
- W2012797534 hasConcept C62112901 @default.
- W2012797534 hasConcept C71924100 @default.
- W2012797534 hasConcept C81885089 @default.
- W2012797534 hasConcept C86803240 @default.
- W2012797534 hasConcept C95444343 @default.
- W2012797534 hasConcept C99454951 @default.
- W2012797534 hasConceptScore W2012797534C104317684 @default.
- W2012797534 hasConceptScore W2012797534C126322002 @default.
- W2012797534 hasConceptScore W2012797534C1491633281 @default.
- W2012797534 hasConceptScore W2012797534C153911025 @default.
- W2012797534 hasConceptScore W2012797534C185592680 @default.
- W2012797534 hasConceptScore W2012797534C2779134260 @default.
- W2012797534 hasConceptScore W2012797534C2908647359 @default.
- W2012797534 hasConceptScore W2012797534C29537977 @default.
- W2012797534 hasConceptScore W2012797534C53345823 @default.
- W2012797534 hasConceptScore W2012797534C54355233 @default.
- W2012797534 hasConceptScore W2012797534C55493867 @default.
- W2012797534 hasConceptScore W2012797534C57089818 @default.
- W2012797534 hasConceptScore W2012797534C62112901 @default.
- W2012797534 hasConceptScore W2012797534C71924100 @default.
- W2012797534 hasConceptScore W2012797534C81885089 @default.
- W2012797534 hasConceptScore W2012797534C86803240 @default.
- W2012797534 hasConceptScore W2012797534C95444343 @default.
- W2012797534 hasConceptScore W2012797534C99454951 @default.
- W2012797534 hasLocation W20127975341 @default.
- W2012797534 hasLocation W20127975342 @default.
- W2012797534 hasOpenAccess W2012797534 @default.
- W2012797534 hasPrimaryLocation W20127975341 @default.
- W2012797534 hasRelatedWork W2012797534 @default.
- W2012797534 hasRelatedWork W2066519212 @default.
- W2012797534 hasRelatedWork W2072481810 @default.
- W2012797534 hasRelatedWork W2132205889 @default.
- W2012797534 hasRelatedWork W2355897695 @default.
- W2012797534 hasRelatedWork W2363880822 @default.
- W2012797534 hasRelatedWork W2373495330 @default.
- W2012797534 hasRelatedWork W2374592133 @default.
- W2012797534 hasRelatedWork W2378203004 @default.
- W2012797534 hasRelatedWork W2387175565 @default.
- W2012797534 isParatext "false" @default.
- W2012797534 isRetracted "false" @default.
- W2012797534 magId "2012797534" @default.
- W2012797534 workType "article" @default.