Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012803540> ?p ?o ?g. }
- W2012803540 endingPage "405" @default.
- W2012803540 startingPage "393" @default.
- W2012803540 abstract "Molecular mechanisms that regulate the generation of hematopoietic and endothelial cells from mesoderm are poorly understood. To define the underlying mechanisms, we compared gene expression profiles between embryonic stem (ES) cell-derived hemangioblasts (Blast-Colony-Forming Cells, BL-CFCs) and their differentiated progeny, Blast cells. Bioinformatic analysis indicated that BL-CFCs resembled other stem cell populations. A role for Gata2, one of the BL-CFC-enriched transcripts, was further characterized by utilizing the in vitro model of ES cell differentiation. Our studies revealed that Gata2 was a direct target of BMP4 and that enforced GATA2 expression upregulated Bmp4, Flk1 and Scl. Conditional GATA2 induction resulted in a temporal-sensitive increase in hemangioblast generation, precocious commitment to erythroid fate, and increased endothelial cell generation. GATA2 additionally conferred a proliferative signal to primitive erythroid progenitors. Collectively, we provide compelling evidence that GATA2 plays specific, contextual roles in the generation of Flk-1+ mesoderm, the Flk-1+Scl+ hemangioblast, primitive erythroid and endothelial cells." @default.
- W2012803540 created "2016-06-24" @default.
- W2012803540 creator A5009645413 @default.
- W2012803540 creator A5020059278 @default.
- W2012803540 creator A5032786824 @default.
- W2012803540 creator A5049522174 @default.
- W2012803540 creator A5057442760 @default.
- W2012803540 creator A5058149977 @default.
- W2012803540 creator A5061937129 @default.
- W2012803540 creator A5070232292 @default.
- W2012803540 creator A5086932115 @default.
- W2012803540 date "2007-01-15" @default.
- W2012803540 modified "2023-10-13" @default.
- W2012803540 title "GATA2 functions at multiple steps in hemangioblast development and differentiation" @default.
- W2012803540 cites W122007457 @default.
- W2012803540 cites W1591850953 @default.
- W2012803540 cites W1991664409 @default.
- W2012803540 cites W2001627351 @default.
- W2012803540 cites W2008025461 @default.
- W2012803540 cites W2009343546 @default.
- W2012803540 cites W2021516648 @default.
- W2012803540 cites W2023455124 @default.
- W2012803540 cites W2024520070 @default.
- W2012803540 cites W2027448315 @default.
- W2012803540 cites W2027914338 @default.
- W2012803540 cites W2036314082 @default.
- W2012803540 cites W2038437697 @default.
- W2012803540 cites W2040425436 @default.
- W2012803540 cites W2043163254 @default.
- W2012803540 cites W2046092689 @default.
- W2012803540 cites W2049197947 @default.
- W2012803540 cites W2050637668 @default.
- W2012803540 cites W2050831107 @default.
- W2012803540 cites W2052426861 @default.
- W2012803540 cites W2059347249 @default.
- W2012803540 cites W2065535087 @default.
- W2012803540 cites W2070451931 @default.
- W2012803540 cites W2072200539 @default.
- W2012803540 cites W2081755366 @default.
- W2012803540 cites W2082152359 @default.
- W2012803540 cites W2084770265 @default.
- W2012803540 cites W2092067368 @default.
- W2012803540 cites W2093252658 @default.
- W2012803540 cites W2096254003 @default.
- W2012803540 cites W2098400443 @default.
- W2012803540 cites W2107141327 @default.
- W2012803540 cites W2115962469 @default.
- W2012803540 cites W2117376104 @default.
- W2012803540 cites W2119375414 @default.
- W2012803540 cites W2119739306 @default.
- W2012803540 cites W2128603782 @default.
- W2012803540 cites W2130604047 @default.
- W2012803540 cites W2132556212 @default.
- W2012803540 cites W2133129825 @default.
- W2012803540 cites W2136223185 @default.
- W2012803540 cites W2142760199 @default.
- W2012803540 cites W2153764250 @default.
- W2012803540 cites W2160802775 @default.
- W2012803540 cites W2170677539 @default.
- W2012803540 cites W2325115379 @default.
- W2012803540 cites W2470460751 @default.
- W2012803540 cites W38135774 @default.
- W2012803540 cites W4237115562 @default.
- W2012803540 doi "https://doi.org/10.1242/dev.02731" @default.
- W2012803540 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17166922" @default.
- W2012803540 hasPublicationYear "2007" @default.
- W2012803540 type Work @default.
- W2012803540 sameAs 2012803540 @default.
- W2012803540 citedByCount "152" @default.
- W2012803540 countsByYear W20128035402012 @default.
- W2012803540 countsByYear W20128035402013 @default.
- W2012803540 countsByYear W20128035402014 @default.
- W2012803540 countsByYear W20128035402015 @default.
- W2012803540 countsByYear W20128035402016 @default.
- W2012803540 countsByYear W20128035402017 @default.
- W2012803540 countsByYear W20128035402018 @default.
- W2012803540 countsByYear W20128035402019 @default.
- W2012803540 countsByYear W20128035402020 @default.
- W2012803540 countsByYear W20128035402022 @default.
- W2012803540 countsByYear W20128035402023 @default.
- W2012803540 crossrefType "journal-article" @default.
- W2012803540 hasAuthorship W2012803540A5009645413 @default.
- W2012803540 hasAuthorship W2012803540A5020059278 @default.
- W2012803540 hasAuthorship W2012803540A5032786824 @default.
- W2012803540 hasAuthorship W2012803540A5049522174 @default.
- W2012803540 hasAuthorship W2012803540A5057442760 @default.
- W2012803540 hasAuthorship W2012803540A5058149977 @default.
- W2012803540 hasAuthorship W2012803540A5061937129 @default.
- W2012803540 hasAuthorship W2012803540A5070232292 @default.
- W2012803540 hasAuthorship W2012803540A5086932115 @default.
- W2012803540 hasBestOaLocation W20128035401 @default.
- W2012803540 hasConcept C104317684 @default.
- W2012803540 hasConcept C109159458 @default.
- W2012803540 hasConcept C143948831 @default.
- W2012803540 hasConcept C145103041 @default.
- W2012803540 hasConcept C201750760 @default.
- W2012803540 hasConcept C203014093 @default.
- W2012803540 hasConcept C20875687 @default.