Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012804004> ?p ?o ?g. }
- W2012804004 endingPage "28" @default.
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- W2012804004 abstract "The aminoacyl-tRNA synthetases are an ancient group of enzymes that catalyze the covalent attachment of an amino acid to its cognate transfer RNA. The question of specificity, that is, how each synthetase selects the correct individual or isoacceptor set of tRNAs for each amino acid, has been referred to as the second genetic code. A wealth of structural, biochemical, and genetic data on this subject has accumulated over the past 40 years. Although there are now crystal structures of sixteen of the twenty synthetases from various species, there are only a few high resolution structures of synthetases complexed with cognate tRNAs. Here we review briefly the structural information available for synthetases, and focus on the structural features of tRNA that may be used for recognition. Finally, we explore in detail the insights into specific recognition gained from classical and atomic group mutagenesis experiments performed with tRNAs, tRNA fragments, and small RNAs mimicking portions of tRNAs. © 2000 John Wiley & Sons, Inc. Biopoly 52: 1–28, 1999" @default.
- W2012804004 created "2016-06-24" @default.
- W2012804004 creator A5015910317 @default.
- W2012804004 creator A5049506879 @default.
- W2012804004 date "1999-01-01" @default.
- W2012804004 modified "2023-10-18" @default.
- W2012804004 title "Transfer RNA recognition by aminoacyl-tRNA synthetases" @default.
- W2012804004 cites W1020623460 @default.
- W2012804004 cites W1021892364 @default.
- W2012804004 cites W1133902369 @default.
- W2012804004 cites W1155189913 @default.
- W2012804004 cites W1442834576 @default.
- W2012804004 cites W1486762928 @default.
- W2012804004 cites W1492811756 @default.
- W2012804004 cites W1498439983 @default.
- W2012804004 cites W1500514988 @default.
- W2012804004 cites W1508132982 @default.
- W2012804004 cites W1510824617 @default.
- W2012804004 cites W1516271347 @default.
- W2012804004 cites W1521901911 @default.
- W2012804004 cites W1523120820 @default.
- W2012804004 cites W1533676256 @default.
- W2012804004 cites W1533677474 @default.
- W2012804004 cites W1540435940 @default.
- W2012804004 cites W1548292434 @default.
- W2012804004 cites W1548556588 @default.
- W2012804004 cites W1553631675 @default.
- W2012804004 cites W1562298896 @default.
- W2012804004 cites W1572009433 @default.
- W2012804004 cites W1584486367 @default.
- W2012804004 cites W1588089207 @default.
- W2012804004 cites W1588145642 @default.
- W2012804004 cites W1602214435 @default.
- W2012804004 cites W1640169075 @default.
- W2012804004 cites W1670590392 @default.
- W2012804004 cites W1711342713 @default.
- W2012804004 cites W1736955968 @default.
- W2012804004 cites W1772912839 @default.
- W2012804004 cites W1797223236 @default.
- W2012804004 cites W1814307112 @default.
- W2012804004 cites W1819124197 @default.
- W2012804004 cites W1822012546 @default.
- W2012804004 cites W184810069 @default.
- W2012804004 cites W1881326155 @default.
- W2012804004 cites W1962582496 @default.
- W2012804004 cites W1963766165 @default.
- W2012804004 cites W1963892922 @default.
- W2012804004 cites W1964946766 @default.
- W2012804004 cites W1965698636 @default.
- W2012804004 cites W1966174219 @default.
- W2012804004 cites W1968917608 @default.
- W2012804004 cites W1968931569 @default.
- W2012804004 cites W1969170660 @default.
- W2012804004 cites W1969744746 @default.
- W2012804004 cites W1970790640 @default.
- W2012804004 cites W1971154617 @default.
- W2012804004 cites W1971918704 @default.
- W2012804004 cites W1972063928 @default.
- W2012804004 cites W1972372154 @default.
- W2012804004 cites W1974066635 @default.
- W2012804004 cites W1974886922 @default.
- W2012804004 cites W1974887347 @default.
- W2012804004 cites W1974959097 @default.
- W2012804004 cites W1975276161 @default.
- W2012804004 cites W1977837589 @default.
- W2012804004 cites W1978583577 @default.
- W2012804004 cites W1978707043 @default.
- W2012804004 cites W1978925476 @default.
- W2012804004 cites W1979028182 @default.
- W2012804004 cites W1979381401 @default.
- W2012804004 cites W1979806605 @default.
- W2012804004 cites W1979818867 @default.
- W2012804004 cites W1981100972 @default.
- W2012804004 cites W1981128082 @default.
- W2012804004 cites W1981167513 @default.
- W2012804004 cites W1981529363 @default.
- W2012804004 cites W1982117955 @default.
- W2012804004 cites W1982261101 @default.
- W2012804004 cites W1982683541 @default.
- W2012804004 cites W1982792515 @default.
- W2012804004 cites W1983371051 @default.
- W2012804004 cites W1984854823 @default.
- W2012804004 cites W1985687578 @default.
- W2012804004 cites W1986586522 @default.
- W2012804004 cites W1988283573 @default.
- W2012804004 cites W1988509685 @default.
- W2012804004 cites W1988630292 @default.
- W2012804004 cites W1989951440 @default.
- W2012804004 cites W1989970032 @default.
- W2012804004 cites W1990205340 @default.
- W2012804004 cites W1990700979 @default.
- W2012804004 cites W1991124799 @default.
- W2012804004 cites W1991418808 @default.
- W2012804004 cites W1991697282 @default.
- W2012804004 cites W1991736514 @default.
- W2012804004 cites W1991867964 @default.
- W2012804004 cites W1992541230 @default.
- W2012804004 cites W1992591280 @default.