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- W2012805145 abstract "The purpose of this work was to determine the response rate and toxicity of a combination of Carmustine and Cisplatin administered before radiation in patients with newly diagnosed high grade astrocytoma. A good response rate has been published with this association in primary cerebral high grade tumor. This protocol was administered in a homogeneous population of 37 adult patients with measurable tumor on magnetic resonance imaging (MRI) or CT scan. After biopsy or subtotal resection, the patients received BCNU 40 mg/m<sup>2</sup>/d and CODP 40 mg/m<sup>2</sup>/d, for 3 days every 28 days for 3 cycles. Evaluation was performed before each cycle. Radiation therapy began 4 weeks after completing the chemotherapy or immediately if there was evidence of tumor progression on chemotherapy. Seven out of 37 (19%) demonstrated tumor regression with a median duration to progression of 11 months. Median survival was 6 months. Myelosupression was the predominant but manageable toxicity. This work indicated that the first chemotherapy protocol gave poor results in a homogeneous group of patients, with bad prognosis." @default.
- W2012805145 created "2016-06-24" @default.
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- W2012805145 date "1999-04-01" @default.
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- W2012805145 title "Identifying the best research design to fit the question. Part 2: qualitative designs" @default.
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- W2012805145 doi "https://doi.org/10.1136/ebn.2.2.36" @default.
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