FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012806465> ?p ?o ?g. }

• W2012806465 endingPage "452" @default.
• W2012806465 startingPage "445" @default.
• W2012806465 abstract "The serine/threonine phosphatase (PP1) isoform PP1 gamma 2, predominantly expressed in the testis, is a key enzyme in spermatozoa. High PP1 gamma 2 catalytic activity holds motility in check in immature spermatozoa. Inhibition of PP1 gamma 2 causes motility initiation in immature spermatozoa and motility stimulation and changes in flagellar beat parameters in mature spermatozoa. The PP1 gamma 2 isoform is present in all mammalian spermatozoa studied: mouse, rat, hamster, bovine, non-human primate and man. We have now identified at least four of its regulatory proteins that regulate distinct pools of PP1 gamma 2 within spermatozoa. Our studies provide new insights into biochemical mechanisms underlying development and regulation of sperm motility. We hypothesize that changes in sperm PP1 gamma 2 activity as a result of phosphorylation and reversible binding of the regulatory proteins to the catalytic subunit are critical in the development and regulation of motility and the ability of sperm to fertilize eggs. Targeted disruption of the Ppp1cc gene, which encodes the PP1 gamma 1 or PP1 gamma 2 isoforms, causes male infertility in mice as a result of impaired spermiogenesis. Our observations suggest that, in addition to motility, the protein phosphatase PP1 gamma 2 might play an isoform-specific function in the development of specialized flagellar structures of mammalian spermatozoa." @default.
• W2012806465 created "2016-06-24" @default.
• W2012806465 creator A5025682541 @default.
• W2012806465 creator A5031570292 @default.
• W2012806465 creator A5063926422 @default.
• W2012806465 creator A5081270915 @default.
• W2012806465 creator A5088372150 @default.
• W2012806465 date "2007-07-01" @default.
• W2012806465 modified "2023-09-25" @default.
• W2012806465 title "Protein phosphatase PP1?2 in sperm morphogenesis and epididymal initiation of sperm motility" @default.
• W2012806465 cites W1488958486 @default.
• W2012806465 cites W1598486028 @default.
• W2012806465 cites W1892570697 @default.
• W2012806465 cites W1941664346 @default.
• W2012806465 cites W1965072420 @default.
• W2012806465 cites W1965483278 @default.
• W2012806465 cites W1982811783 @default.
• W2012806465 cites W1983746023 @default.
• W2012806465 cites W1988979372 @default.
• W2012806465 cites W1992135728 @default.
• W2012806465 cites W1995257839 @default.
• W2012806465 cites W1999802541 @default.
• W2012806465 cites W2014972503 @default.
• W2012806465 cites W2015120218 @default.
• W2012806465 cites W2020841018 @default.
• W2012806465 cites W2020912173 @default.
• W2012806465 cites W2022342379 @default.
• W2012806465 cites W2035222385 @default.
• W2012806465 cites W2040306435 @default.
• W2012806465 cites W2040524146 @default.
• W2012806465 cites W2044694582 @default.
• W2012806465 cites W2050054339 @default.
• W2012806465 cites W2053884909 @default.
• W2012806465 cites W2055029410 @default.
• W2012806465 cites W2071600423 @default.
• W2012806465 cites W2071740910 @default.
• W2012806465 cites W2073893214 @default.
• W2012806465 cites W2074318904 @default.
• W2012806465 cites W2083243773 @default.
• W2012806465 cites W2085202127 @default.
• W2012806465 cites W2091719073 @default.
• W2012806465 cites W2104641310 @default.
• W2012806465 cites W2113384943 @default.
• W2012806465 cites W2113617470 @default.
• W2012806465 cites W2116346467 @default.
• W2012806465 cites W2117962961 @default.
• W2012806465 cites W2120553816 @default.
• W2012806465 cites W2120666332 @default.
• W2012806465 cites W2123227888 @default.
• W2012806465 cites W2128116458 @default.
• W2012806465 cites W2144491728 @default.
• W2012806465 cites W2150478322 @default.
• W2012806465 cites W2156065012 @default.
• W2012806465 cites W2156822306 @default.
• W2012806465 cites W2157017530 @default.
• W2012806465 cites W2157584266 @default.
• W2012806465 cites W2167029999 @default.
• W2012806465 cites W2167671478 @default.
• W2012806465 cites W2252403865 @default.
• W2012806465 cites W4211212229 @default.
• W2012806465 doi "https://doi.org/10.1111/j.1745-7262.2007.00307.x" @default.
• W2012806465 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17589781" @default.
• W2012806465 hasPublicationYear "2007" @default.
• W2012806465 type Work @default.
• W2012806465 sameAs 2012806465 @default.
• W2012806465 citedByCount "48" @default.
• W2012806465 countsByYear W20128064652012 @default.
• W2012806465 countsByYear W20128064652013 @default.
• W2012806465 countsByYear W20128064652014 @default.
• W2012806465 countsByYear W20128064652016 @default.
• W2012806465 countsByYear W20128064652017 @default.
• W2012806465 countsByYear W20128064652018 @default.
• W2012806465 countsByYear W20128064652019 @default.
• W2012806465 countsByYear W20128064652021 @default.
• W2012806465 countsByYear W20128064652022 @default.
• W2012806465 crossrefType "journal-article" @default.
• W2012806465 hasAuthorship W2012806465A5025682541 @default.
• W2012806465 hasAuthorship W2012806465A5031570292 @default.
• W2012806465 hasAuthorship W2012806465A5063926422 @default.
• W2012806465 hasAuthorship W2012806465A5081270915 @default.
• W2012806465 hasAuthorship W2012806465A5088372150 @default.
• W2012806465 hasBestOaLocation W20128064651 @default.
• W2012806465 hasConcept C104317684 @default.
• W2012806465 hasConcept C11960822 @default.
• W2012806465 hasConcept C178666793 @default.
• W2012806465 hasConcept C2777632594 @default.
• W2012806465 hasConcept C2779408958 @default.
• W2012806465 hasConcept C2781087480 @default.
• W2012806465 hasConcept C2781254305 @default.
• W2012806465 hasConcept C389152 @default.
• W2012806465 hasConcept C53345823 @default.
• W2012806465 hasConcept C54355233 @default.
• W2012806465 hasConcept C55493867 @default.
• W2012806465 hasConcept C58207958 @default.
• W2012806465 hasConcept C86803240 @default.
• W2012806465 hasConcept C95444343 @default.
• W2012806465 hasConceptScore W2012806465C104317684 @default.
• W2012806465 hasConceptScore W2012806465C11960822 @default.

• next