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- W2012808235 abstract "Following the implantations of a push-pull cannula into the anterior hypothalamus and a polyethylene cannula into the lateral ventricle of the rat, the brain norepinephrine (NE) stores were labeled by intraventricular injection of 3H-NE. In freely moving nonanesthetized control animals, 4.91 + 0.73 nCi/hr of radioactivity were spontaneously released into the perfusate of the hypothalamus, with 25 percent of the total radioactivity being unchanged NE. Although amphetamine and p-chloroamphetamine caused similar qualitative alterations in the metabolic pattern of 3H-NE in brain tissue, p-chloroamphetamine evoked a striking increase in the release of NE and normetanephrine into the perfusate while pharmacologically equipotent doses of amphetamine elicited only a small increase in the release of NE; the changes in the release of normetanephrine were less pronounced than those caused by p-chloroamphetamine. Since both NE and its O-methylated product are derived mainly from stored tritiated NE, the results support the view that some of the central actions of p-chloroamphetamine may be mediated predominantly through the release of stored catecholamines while the storage of NE and dopamine appears not to be as essential for the central stimulatory action of amphetamine as long as the synthesis of catecholamines is maintained." @default.
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- W2012808235 title "Comparative effects of p-chloroamphetamine and amphetamine on metabolism and in vivo release of 3H-norepinephrine in the hypothalamus" @default.
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- W2012808235 doi "https://doi.org/10.1016/0014-2999(71)90077-x" @default.
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