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• W2012808247 abstract "Interpretation of previous studies of the effects of hypovitaminosis A on salivary glands is confounded by the atrophic effects of liquid or powdered diets. The purpose of this study was to re-evaluate the effects of vitamin A deficiency on the morphology and function of rat salivary glands using a pelleted diet that promotes physiological levels of masticatory. Profound vitamin A deficiency resulted in a marked decrease in stimulated parotid secretion. Histological evaluation demonstrated the development of squamous metaplasia in ducts of parotid, submandibular and sublingual salivary glands; however, atrophy was observed only in serous salivary glands. In the parotid gland the degree of atrophy corresponded to the decrease in stimulated secretion. Mild hypovitaminosis A (before the development of squamous metaplasia in ducts) was associated with distinctly different effects. The parotid gland was moderately enlarged. There was also a significant increase in stimulated secretion, which was not explained by changes in gland size, muscarinic receptor number or affinity, or receptor-mediated calcium signalling." @default.
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• W2012808247 date "1996-08-01" @default.
• W2012808247 modified "2023-10-18" @default.
• W2012808247 title "Response of rat salivary glands to mastication of pelleted vitamin A-deficient diet" @default.
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• W2012808247 doi "https://doi.org/10.1016/s0003-9969(96)00069-6" @default.
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