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• W2012808566 abstract "Summary The preparation and preliminary biological evaluation of a metronidazole-BFCA (bifunctional chelating agent) conjugate labeled with 177 Lu is reported. Metronidazole, a well known hypoxia marker has been suitably derivatized and coupled with a polyazamacrocyclic BFCA, namely, para-aminobenzyl-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid ( p -amino-benzyl-DOTA). 177 Lu, which is presently being considered as one of the pivotal radionuclides for targeted therapy was produced in adequate specific activity (∼185 TBq/g) and high radionuclidic purity (99.99%) by irradiating enriched (60.6% 176 Lu) Lu 2 O 3 target at a moderate thermal neutron flux of 3×10 13 n/cm 2 /s. The metronidazole-BFCA conjugate was radiolabeled with 177 Lu in high radiochemical purity (97%). Preliminary biodistribution studies carried out in Swiss mice bearing fibrosarcoma tumors revealed good tumor uptake (1.30% ID/g at 30 min post-injection) with rapid renal clearance (94.48% ID at 30 min post-injection) and significant tumor to blood (28.00 at 3 h post-injection) and tumor to muscle (14.00 at 3 h post-injection) ratios." @default.
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• W2012808566 date "2006-06-01" @default.
• W2012808566 modified "2023-09-28" @default.
• W2012808566 title "Preparation and preliminary biological evaluation of a ¹⁷⁷Lu labeled nitroimidazole derivative for possible use in targeted tumor therapy" @default.
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• W2012808566 doi "https://doi.org/10.1524/ract.2006.94.6.375" @default.
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