FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012809341> ?p ?o ?g. }

• W2012809341 endingPage "24" @default.
• W2012809341 startingPage "19" @default.
• W2012809341 abstract "Large-conductance Ca(2+) -activated K(+) channels (BKC a ), located on the vascular smooth muscle, play an important role in regulation of vascular tone. In penile corpus cavernosum tissue, opening of BKC a channels leads to relaxation of corporal smooth muscle, which is essential during erection; however, there is little information on the role of BKC a channels located in penile vascular smooth muscle. This study was designed to investigate the involvement of BKC a channels in endothelium-dependent and endothelium-independent relaxation of human intracavernous penile arteries. In human intracavernous arteries obtained in connection with transsexual operations, change in isometric force was recorded in microvascular myographs, and endothelium-dependent [nitric oxide (NO) and endothelium-derived hyperpolarization (EDH)-type] and endothelium-independent (NO-donor) relaxations were measured in contracted arteries. In penile small arteries contracted with phenylephrine, acetylcholine evoked NO- and EDH-type relaxations, which were sensitive to iberiotoxin (IbTX), a selective blocker of BKC a channels. Iberiotoxin also inhibited relaxations induced by a NO-donor, sodium nitroprusside. NS11021, a selective opener of BKC a channels, evoked pronounced relaxations that were inhibited in the presence of IbTX. NS13558, a BKC a -inactive analogue of NS11021, failed to relax human penile small arteries. Our results show that BKC a channels are involved in both NO- and EDH-type relaxation of intracavernous penile arteries obtained from healthy men. The effect of a selective opener of BKC a channels also suggests that direct activation of the channel may be an advantageous approach for treatment of impaired endothelium-dependent relaxation often associated with erectile dysfunction." @default.
• W2012809341 created "2016-06-24" @default.
• W2012809341 creator A5001390784 @default.
• W2012809341 creator A5002319440 @default.
• W2012809341 creator A5003975900 @default.
• W2012809341 creator A5009247683 @default.
• W2012809341 creator A5053960218 @default.
• W2012809341 creator A5055208985 @default.
• W2012809341 creator A5070666929 @default.
• W2012809341 creator A5089074505 @default.
• W2012809341 date "2013-03-21" @default.
• W2012809341 modified "2023-10-15" @default.
• W2012809341 title "Involvement of Large-Conductance Ca²⁺-Activated K⁺Channels in both Nitric Oxide and Endothelium-Derived Hyperpolarization-Type Relaxation in Human Penile Small Arteries" @default.
• W2012809341 cites W1525092122 @default.
• W2012809341 cites W1546802604 @default.
• W2012809341 cites W1825270141 @default.
• W2012809341 cites W1965824307 @default.
• W2012809341 cites W1970445852 @default.
• W2012809341 cites W1971038847 @default.
• W2012809341 cites W1986874670 @default.
• W2012809341 cites W1991353211 @default.
• W2012809341 cites W1993492621 @default.
• W2012809341 cites W1994989484 @default.
• W2012809341 cites W1999051792 @default.
• W2012809341 cites W1999512064 @default.
• W2012809341 cites W2004180956 @default.
• W2012809341 cites W2005196967 @default.
• W2012809341 cites W2007865801 @default.
• W2012809341 cites W2008460098 @default.
• W2012809341 cites W2016258077 @default.
• W2012809341 cites W2020167249 @default.
• W2012809341 cites W2024236856 @default.
• W2012809341 cites W2032283117 @default.
• W2012809341 cites W2033049068 @default.
• W2012809341 cites W2036938051 @default.
• W2012809341 cites W2056273359 @default.
• W2012809341 cites W2058332937 @default.
• W2012809341 cites W2065277421 @default.
• W2012809341 cites W2077897146 @default.
• W2012809341 cites W2091248229 @default.
• W2012809341 cites W2092124361 @default.
• W2012809341 cites W2101669132 @default.
• W2012809341 cites W2105397162 @default.
• W2012809341 cites W2107148217 @default.
• W2012809341 cites W2109713300 @default.
• W2012809341 cites W2122414904 @default.
• W2012809341 cites W2126136540 @default.
• W2012809341 cites W2146056013 @default.
• W2012809341 cites W2149442247 @default.
• W2012809341 cites W2159383994 @default.
• W2012809341 cites W2159811107 @default.
• W2012809341 cites W2164965367 @default.
• W2012809341 cites W2169261085 @default.
• W2012809341 cites W2172264769 @default.
• W2012809341 cites W2174958603 @default.
• W2012809341 cites W2256724151 @default.
• W2012809341 cites W2313724017 @default.
• W2012809341 cites W2321760725 @default.
• W2012809341 doi "https://doi.org/10.1111/bcpt.12059" @default.
• W2012809341 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23414060" @default.
• W2012809341 hasPublicationYear "2013" @default.
• W2012809341 type Work @default.
• W2012809341 sameAs 2012809341 @default.
• W2012809341 citedByCount "21" @default.
• W2012809341 countsByYear W20128093412014 @default.
• W2012809341 countsByYear W20128093412015 @default.
• W2012809341 countsByYear W20128093412016 @default.
• W2012809341 countsByYear W20128093412017 @default.
• W2012809341 countsByYear W20128093412018 @default.
• W2012809341 countsByYear W20128093412019 @default.
• W2012809341 countsByYear W20128093412020 @default.
• W2012809341 countsByYear W20128093412021 @default.
• W2012809341 countsByYear W20128093412022 @default.
• W2012809341 countsByYear W20128093412023 @default.
• W2012809341 crossrefType "journal-article" @default.
• W2012809341 hasAuthorship W2012809341A5001390784 @default.
• W2012809341 hasAuthorship W2012809341A5002319440 @default.
• W2012809341 hasAuthorship W2012809341A5003975900 @default.
• W2012809341 hasAuthorship W2012809341A5009247683 @default.
• W2012809341 hasAuthorship W2012809341A5053960218 @default.
• W2012809341 hasAuthorship W2012809341A5055208985 @default.
• W2012809341 hasAuthorship W2012809341A5070666929 @default.
• W2012809341 hasAuthorship W2012809341A5089074505 @default.
• W2012809341 hasBestOaLocation W20128093411 @default.
• W2012809341 hasConcept C105702510 @default.
• W2012809341 hasConcept C120770815 @default.
• W2012809341 hasConcept C12554922 @default.
• W2012809341 hasConcept C126322002 @default.
• W2012809341 hasConcept C131453863 @default.
• W2012809341 hasConcept C134018914 @default.
• W2012809341 hasConcept C185592680 @default.
• W2012809341 hasConcept C2776992346 @default.
• W2012809341 hasConcept C2777786686 @default.
• W2012809341 hasConcept C2777952589 @default.
• W2012809341 hasConcept C2778509035 @default.
• W2012809341 hasConcept C2779395532 @default.
• W2012809341 hasConcept C2779411790 @default.
• W2012809341 hasConcept C2779610285 @default.

• next