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- W2012809617 abstract "The effect of cortisone upon hepatic parenchymal and ductular cell elements in subacute ethionine intoxication was investigated by electron microscopy. When administered during the florid phase of active ductular cell proliferation and interstitial inflammation, cortisone improved the appearance of the endoplasmic reticulum and mitochondria of the hepatocytes and caused pigment deposition in these cells as well as degeneration of the cells of the bile ductules. Administration during the stationary phase led to change neither in hepatocytes nor in ductular cells. Methionine replacement of ethionine has similar effects on endoplasmic reticulum and mitochondria but did not cause pigment deposition and produced less ductular cell degeneration. Whether suppression of the bile ductular reaction is the result of hepatocellular recovery or is an independent parallel process cannot be decided." @default.
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- W2012809617 date "1962-04-01" @default.
- W2012809617 modified "2023-09-23" @default.
- W2012809617 title "Effect of cortisone on hepatic structure during subacute ethionine intoxication in the rat: An electron microscopic study" @default.
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- W2012809617 doi "https://doi.org/10.1016/0014-4800(62)90014-x" @default.
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