Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012828294> ?p ?o ?g. }
- W2012828294 abstract "Significance African henipaviruses (HNVs) may be responsible for the misdiagnosis of encephalitis-associated outbreaks of malaria. Host-cell infection by an African HNV relies on the initial interaction between a virally encoded surface glycoprotein and a host-cell receptor. Here, we provide a structural description of how a bat-borne Ghanaian HNV hijacks human ephrinB2 to facilitate cross-species transmission. We demonstrate that, although the Ghanian HNV is sequence dissimilar (<30% sequence identity) and displays a receptor-binding scaffold that differs significantly in structure to pathogenic HNV relatives from Asia, it adopts a nearly identical primary ephrinB2 binding mode. These data provide a molecular-level explanation for previously observed spillover of African HNVs into human populations." @default.
- W2012828294 created "2016-06-24" @default.
- W2012828294 creator A5013495583 @default.
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- W2012828294 date "2015-03-30" @default.
- W2012828294 modified "2023-10-01" @default.
- W2012828294 title "Molecular recognition of human ephrinB2 cell surface receptor by an emergent African henipavirus" @default.
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- W2012828294 doi "https://doi.org/10.1073/pnas.1501690112" @default.
- W2012828294 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4418902" @default.
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